Results 111 to 120 of about 22,741 (230)

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF

Journal of Cachexia, Sarcopenia and Muscle
Background Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM).
Beatrice Vahle, Antje Schauer, Antje Augstein, Maria‐Elisa Prieto Jarabo, Janet Friedrich, Peggy Barthel, Anita Männel, Norman Mangner, Siegfried Labeit, T. Scott Bowen, Axel Linke, Volker Adams   +11 more
doaj   +1 more source

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

eLife
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse.
Judith Hüttemeister, Franziska Rudolph, Michael H Radke, Claudia Fink, Dhana Friedrich, Stephan Preibisch, Martin Falcke, Eva Wagner, Stephan E Lehnart, Michael Gotthardt   +9 more
doaj   +1 more source

Deconstructing sarcomeric structure–function relations in titin-BioID knock-in mice

Nature Communications, 2020
Titin determines the elasticity of the sarcomere and integrates into both the Z-disc and the M-band. Here, the authors generate a BioID mouse to study the titin interactome at the Z-disc region in neonatal and adult heart and skeletal muscle.
Franziska Rudolph, Claudia Fink, Judith Hüttemeister, Marieluise Kirchner, Michael H. Radke, Jacobo Lopez Carballo, Eva Wagner, Tobias Kohl, Stephan E. Lehnart, Philipp Mertins, Michael Gotthardt   +10 more
doaj   +1 more source

Understanding the functions of titin and nebulin [PDF]

FEBS Letters, 1992
Individual molecules of the giant muscle proteins titin and nebulin span large distances in the sarcomere. Approximately one‐third of the titin molecule forms elastic filaments linking the ends of thick filaments to the Z‐line. The remainder of the molecule is probably bound to the thick filament where it may regulate assembly of myosin and the other ...
openaire   +2 more sources

Overexpression of Circular RNA circTTN Promotes Ferroptosis in Sepsis‐Induced Cardiomyopathy

Journal of Cellular and Molecular Medicine, Volume 30, Issue 13, July 2026.
ABSTRACT Sepsis‐induced cardiomyopathy (SCM) is one of the common complications caused by sepsis. Despite the higher mortality rate associated with SCM, the pathogenesis of SCM is poorly understood. The study of circular RNA (circRNA) in a variety of diseases has accelerated over recent decades.
Qian Lei, Danyang Zhao, Zhen Wei, Xue Li, Kunjiao Xue, Tingting Zhang, Juanjuan Lyu   +6 more
wiley   +1 more source

Serum titin/creatinine ratio as a biomarker for discriminating disease severity in Duchenne and Becker muscular dystrophies

Frontiers in Neurology
IntroductionDuchenne/Becker muscular dystrophies (DMD/BMD) are inherited muscle diseases, collectively referred to as dystrophinopathy, which are characterized by progressive degeneration or loss.
Yoshinori Nambu, Kayo Osawa, Taku Shirakawa, Aiko Sunami, Shoko Sonehara, Ryosuke Bo, Kandai Nozu, Masafumi Matsuo, Hiroyuki Awano   +8 more
doaj   +1 more source

Effects of chemical myosin II cross‐bridge inhibitors on eccentric force production in skinned muscle fibres

Experimental Physiology, Volume 111, Issue 7, Page 3337-3356, 1 July 2026.
Abstract Eccentric muscle contractions are essential for locomotion and daily activities. Force during these contractions depends on both cross‐bridge (XB) and non‐cross‐bridge (non‐XB) elements, including titin, with contributions varying by fibre type and contraction velocity.
André Tomalka, Sven Weidner, Christian Rode, Tobias Siebert   +3 more
wiley   +1 more source

Investigating the role of titin in skeletal muscles from mdm mice with a deletion in N2A titin [PDF]

, 2021
Muscle physiology is usually considered as a well-developed field which is sufficiently defined by fundamental principles from the sliding filament and swinging cross-bridge theories.
Mishra, Dhruv
core  

A new spring for titin [PDF]

The Journal of Physiology, 2020
Elisabetta Brunello, Luca Fusi
openaire   +2 more sources

Interrelations of aortic spring function, cardiovascular disease risk factors, and left ventricular diastolic function: The Framingham Heart Study

Physiological Reports, Volume 14, Issue 13, July 2026.
Abstract Mechanical twisting and untwisting of the left ventricle as well as abnormal hemodynamic aortic‐ventricular coupling are recognized as contributors to left ventricular diastolic function. However, energy associated with proximal aortic stretch during systole can be recovered as diastolic elastic recoil that may facilitate diastolic left ...
Leroy L. Cooper, Brenton R. Prescott, Vanessa Xanthakis, Jian Rong, Martin G. Larson, Emelia J. Benjamin, Naomi M. Hamburg, Ramachandran S. Vasan, Gary F. Mitchell   +8 more
wiley   +1 more source