Results 101 to 110 of about 26,024 (216)

Titin is a Target of Matrix Metalloproteinase-2

, 2010
Background— Titin is the largest mammalian (≈3000 to 4000 kDa) and myofilament protein that acts as a molecular spring in the cardiac sarcomere and determines systolic and diastolic function.
Mohammad A.M. Ali, Richard Schulz, Henk Granzier, Woo Jung Cho, Bryan Hudson, Zamaneh Kassiri   +5 more
core   +1 more source

MyoMed205 Counteracts Titin Hyperphosphorylation and the Expression of Contraction‐Regulating Proteins in a Rat Model of HFpEF

Journal of Cachexia, Sarcopenia and Muscle
Background Heart failure with preserved ejection fraction (HFpEF) is associated with exercise intolerance, accompanied by alterations in the peripheral skeletal muscle (SKM).
Beatrice Vahle, Antje Schauer, Antje Augstein, Maria‐Elisa Prieto Jarabo, Janet Friedrich, Peggy Barthel, Anita Männel, Norman Mangner, Siegfried Labeit, T. Scott Bowen, Axel Linke, Volker Adams   +11 more
doaj   +1 more source

Perturbation of the titin/MURF1 signaling complex is associated with hypertrophic cardiomyopathy in a fish model and in human patients

Disease Models & Mechanisms, 2019
Hypertrophic cardiomyopathy (HCM) is a hereditary disease characterized by cardiac hypertrophy with diastolic dysfunction. Gene mutations causing HCM have been found in about half of HCM patients, while the genetic etiology and pathogenesis remain ...
Yuta Higashikuse, Nishant Mittal, Takuro Arimura, Sung Han Yoon, Mayumi Oda, Hirokazu Enomoto, Ruri Kaneda, Fumiyuki Hattori, Takeshi Suzuki, Atsushi Kawakami, Alexander Gasch, Tetsushi Furukawa, Siegfried Labeit, Keiichi Fukuda, Akinori Kimura, Shinji Makino   +15 more
doaj   +1 more source

Visualizing sarcomere and cellular dynamics in skeletal muscle to improve cell therapies

eLife
The giant striated muscle protein titin integrates into the developing sarcomere to form a stable myofilament system that is extended as myocytes fuse.
Judith Hüttemeister, Franziska Rudolph, Michael H Radke, Claudia Fink, Dhana Friedrich, Stephan Preibisch, Martin Falcke, Eva Wagner, Stephan E Lehnart, Michael Gotthardt   +9 more
doaj   +1 more source

A new spring for titin [PDF]

The Journal of Physiology, 2020
Elisabetta Brunello, Luca Fusi
openaire   +2 more sources

Serum titin/creatinine ratio as a biomarker for discriminating disease severity in Duchenne and Becker muscular dystrophies

Frontiers in Neurology
IntroductionDuchenne/Becker muscular dystrophies (DMD/BMD) are inherited muscle diseases, collectively referred to as dystrophinopathy, which are characterized by progressive degeneration or loss.
Yoshinori Nambu, Kayo Osawa, Taku Shirakawa, Aiko Sunami, Shoko Sonehara, Ryosuke Bo, Kandai Nozu, Masafumi Matsuo, Hiroyuki Awano   +8 more
doaj   +1 more source

Investigating the role of titin in skeletal muscles from mdm mice with a deletion in N2A titin

, 2021
Muscle physiology is usually considered as a well-developed field which is sufficiently defined by fundamental principles from the sliding filament and swinging cross-bridge theories.
Mishra, Dhruv
core   +1 more source

A new direction for titin pulling [PDF]

Proceedings of the National Academy of Sciences, 2009
Many proteins are known to serve roles as structural scaffolds in cells and tissues. These proteins maintain the shape of the cell, act as local force sensors, and are essential to form tissues that are exposed to large external forces. Although seemingly passive elements, these structural proteins have unique physical features that are worthy of a ...
openaire   +2 more sources

Mechanical properties of titin isoforms.

, 2018
International audienceTitin is a giant filamentous polypeptide of multi-domain construction spanning between the Z- and M-lines of the sarcomere. As a result of differential splicing, length variants of titin are expressed in different skeletal and ...
Labeit, S, Granzier, S, Labeit, D, Redkar, A, Yamasaki, R, Helmes, M, Cazorla, Olivier, McNabb, M, Wu, Y, Kellermayer, K, Trombitás, K   +10 more
core  

Presentation_2_Urinary Titin Is Increased in Patients After Cardiac Surgery.pptx

, 2019
Background: Few non-invasive biomarkers have been used to detect myocardial injury in patients with heart diseases. Recently, the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, which is involved in muscular passive tension and ...
Naritomo Nishioka (6313406), Ko Bando (6313409), Susumu Minamisawa (324230), Takahiro Inoue (128300), Jun Tanihata (437056)   +4 more
core   +1 more source