Results 71 to 80 of about 22,741 (230)
Molecular insights into titin’s A-band
Journal of Muscle Research and Cell Motility, 2023 AbstractThe thick filament-associated A-band region of titin is a highly repetitive component of the titin chain with important scaffolding properties that support thick filament assembly. It also has a demonstrated link to human disease. Despite its functional significance, it remains a largely uncharacterized part of the titin protein.
Fleming, Jennifer R. +4 more
openaire +3 more sources
Cardiovascular toxicity from immune checkpoint inhibitor therapy: an inflammatory continuum
British Journal of Pharmacology, EarlyView.Immune checkpoint inhibitor (ICI) therapy has markedly improved outcomes in advanced malignancies but has also revealed a distinct spectrum of cardiovascular immune‐related adverse events. Myocarditis represents the most severe manifestation, while non‐inflammatory left ventricular dysfunction and vascular inflammation have emerged as additional ...
Fabrice Reyes +7 more
wiley +1 more source
Presentation_2_Urinary Titin Is Increased in Patients After Cardiac Surgery.pptx [PDF]
, 2019 Background: Few non-invasive biomarkers have been used to detect myocardial injury in patients with heart diseases. Recently, the N-terminal fragment (N-titin) of titin, a giant sarcomeric protein, which is involved in muscular passive tension and ...
Naritomo Nishioka (6313406) +4 more
core +1 more source
The Scientific World Journal, 2001 Titin is an extraordinary long multidomain protein spanning half of the sarcomeric unit. One end of the titin filament is known to emerge from the Z-line, but the precise localization of the other end is still a matter of debate.
Dan Eremia
doaj +1 more source
Evolution of the Highly Repetitive PEVK Region of Titin Across Mammals
G3: Genes, Genomes, Genetics, 2019 The protein titin plays a key role in vertebrate muscle where it acts like a giant molecular spring. Despite its importance and conservation over vertebrate evolution, a lack of high quality annotations in non-model species makes comparative evolutionary
Kathleen Muenzen +2 more
doaj +1 more source
RASD2 Drives Renal Clear Cell Carcinoma Progression via RAF1 (Ser338) Phosphorylation
Cancer Science, EarlyView.RASD2 drives clear cell renal cell carcinoma (ccRCC) progression by physically interacting with RAF1 to induce its Ser338 phosphorylation, which subsequently activates the P38/ERK–MAPK signaling pathway to promote malignant tumor phenotypes and poor prognosis.
Jingxuan Yu +10 more
wiley +1 more source
Mechanical properties of titin isoforms. [PDF]
, 2018 International audienceTitin is a giant filamentous polypeptide of multi-domain construction spanning between the Z- and M-lines of the sarcomere. As a result of differential splicing, length variants of titin are expressed in different skeletal and ...
Labeit, S +10 more
core
Detection of titin fragments in urine in response to exercise-induced muscle damage. [PDF]
PLoS ONE, 2017 Many studies have attempted to determine the associations between blood biomarkers and exercise-induced muscle damage. However, poor correlations between the changes in biomarker levels and the magnitude of muscle symptoms have been reported.
Kazue Kanda +4 more
doaj +1 more source
The FEBS Journal, EarlyView.Trim32 regulates the transition from proliferation to differentiation in C2C12 cells after myogenic induction. We found that, at the onset of differentiation, Trim32 destabilizes c‐Myc mRNA, promotes cell cycle exit, and enables normal myotube formation.
Lu Xiong +6 more
wiley +1 more source
Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle
Frontiers in Physiology, 2014 The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser +1 more
doaj +1 more source