Results 71 to 80 of about 26,024 (216)
Evolution of the Highly Repetitive PEVK Region of Titin Across Mammals
G3: Genes, Genomes, Genetics, 2019 The protein titin plays a key role in vertebrate muscle where it acts like a giant molecular spring. Despite its importance and conservation over vertebrate evolution, a lack of high quality annotations in non-model species makes comparative evolutionary
Kathleen Muenzen +2 more
doaj +1 more source
Experimental Physiology, EarlyView.Abstract Ageing is associated with loss of skeletal muscle mass and strength (sarcopenia) and disrupted redox homeostasis. Redox signalling is essential for muscle adaptation, yet the mechanisms by which ageing disrupts cysteine‐based regulation are poorly defined. The drivers of site‐specific reactivity and signalling specificity in aged muscle remain
Ufuk Ersoy, Malcolm J. Jackson
wiley +1 more source
Cytoskeleton: Titin as a scaffold and spring [PDF]
, 1996 The complete sequence of the giant muscle protein titin has been determined. It provides further insight into how titin may act both as a scaffold and a spring to specify and maintain muscle ...
Trinick, John
core +1 more source
The Scientific World Journal, 2001 Titin is an extraordinary long multidomain protein spanning half of the sarcomeric unit. One end of the titin filament is known to emerge from the Z-line, but the precise localization of the other end is still a matter of debate.
Dan Eremia
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A New Paradigm for Muscle Contraction
Frontiers in Physiology, 2015 For the past 60 years, muscle contraction had been thought to be governed exclusively by the contractile filaments, actin and myosin. This thinking explained most observations for concentric and isometric, but not for eccentric muscle contractions.
Walter eHerzog +3 more
doaj +1 more source
Animal Genetics, Volume 57, Issue 5, October 2026.ABSTRACT Previous studies suggest that genetic risk factors for dilated cardiomyopathy (DCM) in Dobermann dogs may differ between populations, complicating the use of genetic tests across subpopulations. Variants in pyruvate dehydrogenase kinase 4 (PDK4) and titin (TTN) have been associated with DCM in North American Dobermanns, whereas two loci on ...
Alma H. Hulsman +15 more
wiley +1 more source
Detection of titin fragments in urine in response to exercise-induced muscle damage. [PDF]
PLoS ONE, 2017 Many studies have attempted to determine the associations between blood biomarkers and exercise-induced muscle damage. However, poor correlations between the changes in biomarker levels and the magnitude of muscle symptoms have been reported.
Kazue Kanda +4 more
doaj +1 more source
The Journal of Cell Biology, 2002 ![Graphic][1] Titin extends first via N2B unravelling (smooth curve) before Ig domains give way (peaks). Fernandez/MacmillanIn a homage to reductionism, Hongbin Li, Julio Fernandez (Columbia University, New York, NY), and colleagues show that the properties of individual domains ...
openaire +2 more sources
Journal of Cachexia, Sarcopenia and Muscle, Volume 17, Issue 5, October 2026.ABSTRACT Background Autosomal dominant centronuclear myopathy (ADCNM), most commonly caused by mutations in the dynamin 2 (DNM2) gene, is a rare congenital myopathy characterized by progressive muscle weakness and atrophy. Myostatin, a key negative regulator of skeletal muscle mass, has shown therapeutic potential in several models of neuromuscular ...
Durieux Anne‐Cécile +20 more
wiley +1 more source
Titin Isoform Size is Not Correlated with Thin Filament Length in Rat Skeletal Muscle
Frontiers in Physiology, 2014 The mechanisms controlling thin filament length in muscle remain controversial. It was recently reported that thin filament length was related to titin size, and that the latter might be involved in thin filament length determination.
Marion Lewis Greaser +1 more
doaj +1 more source