Results 21 to 30 of about 26,024 (216)
Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics
Redox Biology, 2022 Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key role in diastolic function and is a determinant factor in the etiology of heart disease.
Elías Herrero-Galán +17 more
doaj +1 more source
, 2022 Aims: Dilated cardiomyopathy (DCM) is associated with mutations in many genes encoding sarcomere proteins. Truncating mutations in the titin gene TTN are the most frequent.
Maya Guglin (5773304) +11 more
core +1 more source
Journal of Physical Fitness and Sports Medicine, 2021 Urinary titin fragment concentration has been established as a noninvasive biomarker of muscle protein degradation and muscle damage after exercise. We hypothesized that concerning the microdamage in the chronic phase of muscle strain injury, muscle ...
Tomonori Kawai +2 more
doaj +1 more source
Structural investigation of the molecular mechanisms underlying titin elasticity and signaling [PDF]
, 2010 Titin is a giant protein that spans >1µm from the Z-disc to the M-line, forming an intrasarcomeric filament system in vertebrate striated muscle, which is not only essential for the assembly of the sarcomere, but also critical for myofibril signaling and
Castelmur, Eleonore von
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Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D
Frontiers in Physiology, 2020 The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy,
Melissa Herwig +34 more
doaj +1 more source
RBM20, a Therapeutic Target to Alleviate Myocardial Stiffness via Titin Isoforms Switching in HFpEF
Frontiers in Cardiovascular Medicine, 2022 Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial stiffness mainly derives from cardiomyocyte- and extracellular matrix (
Na Li +3 more
doaj +1 more source
Structural studies on protein scaffolds related to muscle physiology and disease : the titin filament, its associated component MuRF-1 and nuclear LAP2[alpha] [PDF]
, 2006 The titin molecule has a length of overµm and functions as a colossal protein scaffold in the muscle sarcomere. Up to 90% of its total mass is composed of repetitive immunoglobulin (Ig) and fibronectin (FnIII) domains that form linear tandems ...
Mrosek, Michael Christian
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The Journal of Cell Biology, 2000 Previously, we reported that chromosomes contain a giant filamentous protein, which we identified as titin, a component of muscle sarcomeres. Here, we report the sequence of the entire titin gene in Drosophila melanogaster, D-Titin, and show that it encodes a two-megadalton protein with significant colinear homology to the NH2-terminal half of ...
C, Machado, D J, Andrew
openaire +2 more sources
Frontiers in Physiology, 2019 Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent genetic defects are truncation variants of the titin gene (TTNtv). TTN
Charles A. Tharp +4 more
doaj +1 more source
Structural insights into the basis and evolution of interactions in multi-subunit protein assemblies. tryptophan synthase and titin FNIII-repeats [PDF]
, 2008 Cellular processes benefit from evolutionary shaping when optimized protein-protein interactions result in enhanced functionality. In fact, most cellular proteins are tightly embedded into biological networks that function following a modularity ...
Bucher, Rainer Michael
core +1 more source