Results 21 to 30 of about 22,741 (230)
Scientific Reports, 2023 This study aimed to examine the validity of urinary N-terminal titin fragment/creatinine (urinary N-titin/Cr) reflecting muscle damage biomarker in patients with interstitial lung disease. This retrospective study enrolled patients with interstitial lung
Masatoshi Hanada +12 more
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Basal oxidation of conserved cysteines modulates cardiac titin stiffness and dynamics
Redox Biology, 2022 Titin, as the main protein responsible for the passive stiffness of the sarcomere, plays a key role in diastolic function and is a determinant factor in the etiology of heart disease.
Elías Herrero-Galán +17 more
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Computing Average Passive Forces in Sarcomeres in Length-Ramp Simulations. [PDF]
PLoS Computational Biology, 2016 Passive forces in sarcomeres are mainly related to the giant protein titin. Titin's extensible region consists of spring-like elements acting in series.
Gudrun Schappacher-Tilp +3 more
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Modulation of Titin-Based Stiffness in Hypertrophic Cardiomyopathy via Protein Kinase D
Frontiers in Physiology, 2020 The giant protein titin performs structure-preserving functions in the sarcomere and is important for the passive stiffness (Fpassive) of cardiomyocytes. Protein kinase D (PKD) enzymes play crucial roles in regulating myocardial contraction, hypertrophy,
Melissa Herwig +34 more
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RBM20, a Therapeutic Target to Alleviate Myocardial Stiffness via Titin Isoforms Switching in HFpEF
Frontiers in Cardiovascular Medicine, 2022 Increased myocardial stiffness is critically involved in heart diseases with impaired cardiac compliance, especially heart failure with preserved ejection fraction (HFpEF). Myocardial stiffness mainly derives from cardiomyocyte- and extracellular matrix (
Na Li +3 more
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Journal of Physical Fitness and Sports Medicine, 2021 Urinary titin fragment concentration has been established as a noninvasive biomarker of muscle protein degradation and muscle damage after exercise. We hypothesized that concerning the microdamage in the chronic phase of muscle strain injury, muscle ...
Tomonori Kawai +2 more
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Structural investigation of the molecular mechanisms underlying titin elasticity and signaling [PDF]
, 2010 Titin is a giant protein that spans >1µm from the Z-disc to the M-line, forming an intrasarcomeric filament system in vertebrate striated muscle, which is not only essential for the assembly of the sarcomere, but also critical for myofibril signaling and
Castelmur, Eleonore von
core +1 more source
Structural studies on protein scaffolds related to muscle physiology and disease : the titin filament, its associated component MuRF-1 and nuclear LAP2[alpha] [PDF]
, 2006 The titin molecule has a length of overµm and functions as a colossal protein scaffold in the muscle sarcomere. Up to 90% of its total mass is composed of repetitive immunoglobulin (Ig) and fibronectin (FnIII) domains that form linear tandems ...
Mrosek, Michael Christian
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Frontiers in Physiology, 2019 Dilated cardiomyopathy (DCM) is a leading cause of heart failure, sudden cardiac death and heart transplant. DCM is inherited in approximately 50% of cases, in which the most frequent genetic defects are truncation variants of the titin gene (TTNtv). TTN
Charles A. Tharp +4 more
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The skeletal muscle circadian clock regulates titin splicing through RBM20
eLife, 2022 Circadian rhythms are maintained by a cell-autonomous, transcriptional–translational feedback loop known as the molecular clock. While previous research suggests a role of the molecular clock in regulating skeletal muscle structure and function, no ...
Lance A Riley +12 more
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