Results 181 to 190 of about 148,086 (284)

Synthetic Cathepsin B Sensitive Adjuvant‐Peptide Conjugates to Target Intracellular Toll‐Like Receptors 7 and 8

ChemistryEurope, EarlyView.
Cathepsin B‐sensitive peptide–adjuvant conjugates are designed, synthesized, and evaluated to deliver an antigenic peptid and an adjuvant targeting Toll‐like receptors 7 and 8 (TLR7/8) to antigen presenting cells. The adjuvant is released by cathepsin B resulting in antigen presentation and TLR mediated T cell activation.
Marjolein M. E. Isendoorn, Giulia Castello, Nico J. Meeuwenoord, Martijn Verdoes, Jeroen D. C. Codée, Ferry Ossendorp, Dmitri V. Filippov   +6 more
wiley   +1 more source

Vortioxetine alleviates motor, cognitive and emotional disorders in post-stroke rats by regulating the TLR-2/NF-<i>κ</i>B pathway. [PDF]

Front Pharmacol
Dong Z, Dong Z, Xu L, Zhang J, Li L, Wang R, Huang X, Zou Z.   +7 more
europepmc   +1 more source

Systemic aging fuels heart failure: Molecular mechanisms and therapeutic avenues

ESC Heart Failure, Volume 12, Issue 2, Page 1059-1080, April 2025.
Abstract Systemic aging influences various physiological processes and contributes to structural and functional decline in cardiac tissue. These alterations include an increased incidence of left ventricular hypertrophy, a decline in left ventricular diastolic function, left atrial dilation, atrial fibrillation, myocardial fibrosis and cardiac ...
Zhuyubing Fang, Umar Raza, Jia Song, Junyan Lu, Shun Yao, Xiaohong Liu, Wei Zhang, Shujuan Li   +7 more
wiley   +1 more source

Features of toll-like receptor genes (TLR-2, TLR-3, TLR-4 and TLR-6) polymorphism in open-angle glaucoma patients. [PDF]

Vavilovskii Zhurnal Genet Selektsii
Shevchenko AV, Prokofiev VF, Konenkov VI, Chernykh VV, Trunov AN.   +4 more
europepmc   +1 more source

Association of TLR-2 Gene Polymorphisms with the Risk of Periodontitis: A Meta-Analysis. [PDF]

Dis Markers, 2020
Shan C, Aisaiti A, Wu ZP, Wang TT, Zhao J.   +4 more
europepmc   +1 more source

Akut romatizmal ateş tanısı alan hastalarda TLR-2 geninde Arg753Gln ve Arg677Trp polimorfizmi

, 2020
Akut romatizmal ateş; A grubu beta hemolitik streptokoka bağlı tonsillofarenjitin 2-3 haftalık latent periyodu takiben gelişen süpüratif olmayan bir sekelidir. Toll-like reseptörler (TLR), çok hücreli organizmalarda yabancı mikrobiyal hücre ürünlerini organizmanın savunma cevabına sunan sensörlerdir.
openaire   +2 more sources

Gut microbiota‐related modulation of immune mechanisms in post‐infarction remodelling and heart failure

ESC Heart Failure, Volume 12, Issue 2, Page 942-954, April 2025.
Abstract The immune system has long been recognized as a key driver in the progression of heart failure (HF). However, clinical trials targeting immune effectors have consistently failed to improve patient outcome across different HF aetiologies. The activation of the immune system in HF is complex, involving a broad network of pro‐inflammatory and ...
Johann Roessler, Friederike Zimmermann, Bettina Heidecker, Ulf Landmesser, Arash Haghikia   +4 more
wiley   +1 more source

Variants rs3804099 and rs3804100 in the TLR2 Gene Induce Different Profiles of TLR-2 Expression and Cytokines in Response to Spike of SARS-CoV-2. [PDF]

Int J Mol Sci
Flores-González J, Monroy-Rodríguez Z, Falfán-Valencia R, Buendía-Roldán I, Fricke-Galindo I, Hernández-Zenteno R, Herrera-Sicairos R, Chávez-Galán L, Pérez-Rubio G.   +8 more
europepmc   +1 more source

Insulin‐like growth factor 1 receptor correlates with verbal memory in ILAE type 2 hippocampal sclerosis

Epilepsia, EarlyView.
Abstract Objective Long‐term memory deficits are often seen in patients with temporal lobe epilepsy (TLE). Recently, studies showed that patients with hippocampal sclerosis (HS) type 2, which presents with severe neuron loss in CA1 only, performed within the normal range. However, up to 30% of HS type 2 cases have memory deficits.
Henrique Cruz, Amauri Batista de Oliveira‐Júnior, André Fernando Garcia Cortez, Ricardo Lutzky Saute, Ricardo Silva Centeno, Joao Norberto Stávale, Mirian Salvadori Bittar Guaranha, Elza Marcia Targas Yacubian, Esper Abrão Cavalheiro, Joao Pereira Leite, Jose Eduardo Peixoto‐Santos   +10 more
wiley   +1 more source

Sulfate-Reducing Bacteria Induce Pro-Inflammatory TNF-α and iNOS via PI3K/Akt Pathway in a TLR 2-Dependent Manner. [PDF]

Microorganisms
Singh SB, Braun CA, Carroll-Portillo A, Coffman CN, Lin HC.   +4 more
europepmc   +1 more source