Results 251 to 260 of about 148,086 (284)

Dysregulation of toll-like receptor-2 (TLR-2)-induced effects in monocytes from patients with atopic dermatitis: impact of the TLR-2 R753Q polymorphism

Allergy: European Journal of Allergy and Clinical Immunology, 2008
Background:  Atopic dermatitis (AD) is often complicated by an enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus. Toll‐like receptors (TLR), especially TLR‐2 recognizes cell wall components of S. aureus, e.g. lipoteichoic acid (LTA) and peptidoglycan (PGN).
M, Niebuhr, J, Langnickel, C, Draing, H, Renz, A, Kapp, T, Werfel   +5 more
exaly   +3 more sources

Impaired TLR‐2 expression and TLR‐2‐mediated cytokine secretion in macrophages from patients with atopic dermatitis

Allergy, 2009
Background:  In many patients with atopic dermatitis (AD), the disease is complicated by their enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus. The pattern recognition receptor toll‐like receptor (TLR)‐2 recognizes components of S.
M, Niebuhr, C, Lutat, S, Sigel, T, Werfel   +3 more
openaire   +2 more sources

POSTISCHEMIC VASCULAR PERMEABILITY REQUIRES BOTH TLR-2 AND TLR-4, BUT ONLY TLR-2 MEDIATES THE TRANSENDOTHELIAL MIGRATION OF LEUKOCYTES

Shock, 2009
Ischemia-reperfusion (I/R) activates innate immunity involving Toll-like receptor (TLR) 2 and TLR-4 signaling. Leukocyte migration and vascular permeability contribute to postischemic tissue damage. We hypothesized that TLR-2 and TLR-4 directly mediate leukocyte migration and vascular permeability during I/R.
Alexander Georg, Khandoga, Andrej, Khandoga, Hans-Joachim, Anders, Fritz, Krombach   +3 more
openaire   +2 more sources

The effects of age on CD4+ T cell TLR-2 expression and TLR-2 mediated direct co-stimulation (122.6)

The Journal of Immunology, 2012
Abstract Background: Functional Toll like receptors (TLR) are found on human T cells. Neonatal antigen presenting cells (APC) have altered responses to TLR ligands; it is unknown if neonatal CD4+ T cell TLR responses are comparable to adult. Objective: Comparison of TLR-2 expression and responsiveness to TLR-2 direct co-stimulation among
Christina Lancioni, Brian Sinnott, Megan Null, David Lewinsohn, Deborah Lewinsohn   +4 more
openaire   +1 more source

Brucella abortus induces mast cell activation through TLR-2 and TLR-4

Microbial Pathogenesis, 2023
The Gram-negative bacteria Brucella abortus is a major cause of brucellosis in animals and humans. The host innate immune response to B. abortus is mainly associated with phagocytic cells such as dendritic cells, neutrophils, and macrophages. However, as mast cells naturally reside in the main bacterial entry sites they may be involved in bacterial ...
Adriana Dominguez-Flores, Gloria M. Rodríguez López, Rodolfo Soria-Castro, Rubén López-Santiago, Octavio Rodríguez-Cortés, Sonia M. Pérez-Tapia, Alma D. Chávez-Blanco, Sergio Estrada-Parra, Raúl Flores-Mejía, Rommel Chacón-Salinas   +9 more
openaire   +2 more sources

Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction

Molecular and Cellular Biochemistry, 2012
Post-translational modification by monoclonal nonspecific suppressor factor β (MNSFβ) has been involved in the regulation of a variety of cellular processes. Previous studies have demonstrated that MNSFβ covalently binds to the intracellular pro-apoptotic protein Bcl-G and regulates TLR-4-mediated signal transduction. Recently, we found that MNSFβ also
Morihiko, Nakamura, Jun, Watanabe, Natsuko, Watanabe   +2 more
openaire   +2 more sources

TLR‐2‐mediated cytokine and chemokine secretion in human keratinocytes

Experimental Dermatology, 2010
Abstract:  The human epidermis provides a first line of defense against exogenous pathogens. Resistance to bacterial skin infections, e.g. with Staphylococcus aureus (S. aureus), is based on the function of intact innate immune mechanisms in the epidermis, mainly provided by keratinocytes. They establish the local cytokine and chemokine milieu which is
Margarete, Niebuhr, Kathrin, Baumert, Thomas, Werfel   +2 more
openaire   +2 more sources

Assessment of TLR-2 concentration in tick-borne encephalitis and neuroborreliosis

Scandinavian Journal of Clinical and Laboratory Investigation, 2019
The aim of the study was to check whether measurement of TLR-2 in serum or cerebrospinal fluid (CSF) can help differentiate between neuroborreliosis (NB) and tick-borne encephalitis (TBE). Eighty patients with meningitis and meningoencephalitis were divided into two groups: Group I - patients with NB (n = 40) and Group II - patients with TBE (n = 40 ...
Anna, Moniuszko-Malinowska, Paweł, Penza, Piotr, Czupryna, Olga, Zajkowska, Sławomir, Pancewicz, Monika, Król, Renata, Świerzbińska, Justyna, Dunaj, Joanna, Zajkowska   +8 more
openaire   +3 more sources

Novel 1,2,3-triazole-tethered Pam3CAG conjugates as potential TLR-2 agonistic vaccine adjuvants

Bioorganic Chemistry, 2021
A focused library of water soluble 1,2,3-triazole tethered glycopeptide conjugates derived from variety of azido-monosaccharides and aliphatic azido-alcohols were synthesized through manipulation at the C-terminus of Pam3CAG and screened for their potential as TLR2 agonistic adjuvants against HBsAg antigen.
Tukaram B, Mhamane, Shainy, Sambyal, Sravanthi, Vemireddy, Imran A, Khan, Syed, Shafi, Sampath Kumar, Halmuthur M   +5 more
openaire   +2 more sources

Human neutrophils and TLRs: 2, 4, and plenty more

Blood, 2003
And who could be truly surprised? Toll-like receptors (TLRs) are orthologs of combined developmental polarization and host defense proteins identified in the fruit fly, Drosophila melanogaster , and respond to molecular motifs that are distinct and unique features of bacterial, fungal, and ...
openaire   +1 more source