Results 231 to 240 of about 17,805,524 (287)

Type I interferon overactivation in sera of patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease

Rheumatology &Autoimmunity, EarlyView.
Sera from patients with anti‐MDA5‐positive dermatomyositis‐associated interstitial lung disease (ILD) exhibit significantly higher type I interferon (IFN‐I) bioactivity and interferon‐stimulated gene‐inducing activity compared to anti‐ARS‐positive ILD and healthy controls.
Shohei Nakamura, Yasuhiro Katsumata, Yuko Okamoto, Masayoshi Harigai   +3 more
wiley   +1 more source

Antiulcerogenic Activity of Li-Zhong Decoction on Duodenal Ulcers Induced by Indomethacin in Rats: Involvement of TLR-2/MyD88 Signaling Pathway.

Evid Based Complement Alternat Med, 2020
Song H, Zeng M, Chen X, Chen X, Peng J, Lin Y, Yu R, Cai X, Peng Q.   +8 more
europepmc   +1 more source

Toll-Like Receptor 2 (TLR-2) Gene Polymorphisms in Type 2 Diabetes Mellitus. [PDF]

Cell J, 2019
Ermiş Karaali Z, Candan G, Aktuğlu MB, Velet M, Ergen A.   +4 more
europepmc   +1 more source

Noise‐Induced Hearing Loss: From Pathological Mechanisms to Therapeutic Interventions

Sensory Neuroscience, EarlyView.
ABSTRACT Noise‐induced hearing loss (NIHL), a significant non‐genetic form of hearing impairment, is primarily managed through the use of hearing aids and cochlear implants. However, the fundamental pathological mechanisms underlying NIHL remain inadequately addressed.
Shiqi Huang, Yu Xiao, Jiaxin Liu, Wen Jiang, Weiwei Shi, Hanbing Zhang, Xiaolong Fu, Yunhao Wu   +7 more
wiley   +1 more source

Defective MyD88 and IRAK4 but not TLR-2 expression in HIV+ individuals with latent tuberculosis infection. [PDF]

Cytokine, 2018
Devalraju KP, Neela VSK, Gaddam R, Chaudhury A, Van A, Krovvidi SS, Vankayalapati R, Valluri VL.   +7 more
europepmc   +1 more source

Progress On Sensorineural Hearing Loss: Mechanisms and Therapies

Sensory Neuroscience, EarlyView.
ABSTRACT Hearing loss is the most common disabling disease among humans, which adversely affects human health. Sensorineural hearing loss (SNHL) accounting for approximately 63% of all hearing loss cases. SNHL may be classified into age‐related hearing loss (ARHL), drug‐induced hearing loss (DIHL), noise‐induced hearing loss (NIHL), and sudden ...
Yuan Zhang, Shen Li, Yangfan Zhou, Duopin Li, Junru Ding, Ruifeng Qiao, Yutian Chen, Fanglei Ye, Le Wang, Peipei Li   +9 more
wiley   +1 more source

TLR-2 and MyD88-Dependent Activation of MAPK and STAT Proteins Regulates Proinflammatory Cytokine Response and Immunity to Experimental Trypanosoma congolense Infection. [PDF]

Front Immunol, 2019
Kuriakose S, Onyilagha C, Singh R, Olayinka-Adefemi F, Jia P, Uzonna JE.   +5 more
europepmc   +1 more source

Human Colitis‐on‐Chip Model Reveals Dual Roles of Butyrate in Epithelial and Macrophage Defense Against Candida albicans Tissue Invasion

Small, EarlyView.
This study establishes a human immunocompetent colitis‐on‐chip model that mimics inflamed gut mucosa and enables quantitative analysis of Candida albicans tissue invasion under DSS‐induced injury. It reveals that microbiota‐derived butyrate simultaneously stabilizes epithelial junctions and reprograms macrophages via HDAC/NLRP3‐dependent mechanisms ...
Manuel Allwang, Maximilian Wipplinger, Parastoo Akbarimoghaddam, Raquel Alonso‐Roman, Zoltan Cseresnyes, Axel Dietschmann, Valentin Wegner, Adrian Feile, Yann Bachelot, Maria Warschinke, Mohamed I. Abdelwahab Hassan, Sonnhild Mittag, Otmar Huber, Bernhard Hube, Mark S. Gresnigt, Marc Thilo Figge, Alexander S. Mosig   +16 more
wiley   +1 more source

Applications of chitosan derivatives as adjuvants for nanoparticle‐based vaccines: A comprehensive review

Smart Molecules, EarlyView.
This review highlights how chitosan derivatives enhance nanoparticle‐based vaccines through superior stability, mucoadhesion, and immune modulation. By triggering robust mucosal, humoral, and cellular responses, these biocompatible polymers serve as a transformative platform for next‐generation immunotherapeutics and safe and effective vaccine delivery
Sayantani Dasgupta, Susanta Paul, Swarupananda Mukherjee, Nilanjan Sarkar, Arvind Kumar, Amrita Chakraborty, Anannya Bose, Atanu Hazra, Mainak Chakraborty   +8 more
wiley   +1 more source

Antimicrobial Residues in a Key Cerrado River: Distribution, Persistence, and Effects on Zebrafish Embryo‐Larval Development

Environmental Toxicology, EarlyView.
ABSTRACT The current study aimed to quantify the antimicrobials amoxicillin (AMX), cefazolin (CFZ), chloramphenicol (CHL), metronidazole (MTZ), and sulfamethoxazole (SX) in effluents and surface water of an important Cerrado river, calculate their half‐lives, and analyze their ecotoxicity following single and combined exposures.
Náthala Maria Simão, Igor Romeiro dos Santos, Jerônimo Raimundo de Oliveira Neto, Flávio Olimpio Sanches Neto, Felipe Cirqueira Dias, Jéssyca Moreira Morais, Lorranny Pereira de Assis Valadares, Naiara Raica Lopes de Oliveira, Mirelle Garcia Silva Bailão, Luiz Carlos da Cunha, Valter Henrique Carvalho‐Silva, Thiago Lopes Rocha, Elisa Flávia Luiz Cardoso Bailão   +12 more
wiley   +1 more source