Results 251 to 260 of about 17,805,524 (287)

Synergy between TLR-2 and TLR-3 signaling in primary human nasal epithelial cells

Immunobiology, 2015
Although we have a detailed understanding of how single microbial derived triggers activate specialized Toll-like receptors (TLR) on airway epithelial cells, we know little of how these receptors react in a more complex environment.
Korneliusz Golebski, Danielle van Egmond, Wytske J Fokkens   +2 more
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The effects of age on CD4+ T cell TLR-2 expression and TLR-2 mediated direct co-stimulation (122.6)

The Journal of Immunology, 2012
Abstract Background: Functional Toll like receptors (TLR) are found on human T cells. Neonatal antigen presenting cells (APC) have altered responses to TLR ligands; it is unknown if neonatal CD4+ T cell TLR responses are comparable to adult. Objective: Comparison of TLR-2 expression and responsiveness to TLR-2 direct co-stimulation among
Christina Lancioni, Brian Sinnott, Megan Null, David Lewinsohn, Deborah Lewinsohn   +4 more
openaire   +1 more source

TLR-2 Germ Line Variants as a Risk for Obesity in Local Pakistani Population

Archives of Medical Research, 2022
Obesity is increasing rapidly affecting half billion adult's population. Pathophysiology of obesity involves low grade inflammation sustained by Toll like receptor 2 (TLR-2) the innate immune adapters. This study was conducted for detection and association of TLR-2 gene mutations with obesity.In this case-control study 228 individuals with obesity and ...
Mehreen Shoukat, Rooh Ullah, Maheen Javaid, Muhammad Anas, Mariam Tariq, Rani Faryal   +5 more
openaire   +2 more sources

TLR‐2‐mediated cytokine and chemokine secretion in human keratinocytes

Experimental Dermatology, 2010
Abstract:  The human epidermis provides a first line of defense against exogenous pathogens. Resistance to bacterial skin infections, e.g. with Staphylococcus aureus (S. aureus), is based on the function of intact innate immune mechanisms in the epidermis, mainly provided by keratinocytes. They establish the local cytokine and chemokine milieu which is
Margarete, Niebuhr, Kathrin, Baumert, Thomas, Werfel   +2 more
openaire   +2 more sources

Assessment of TLR-2 concentration in tick-borne encephalitis and neuroborreliosis

Scandinavian Journal of Clinical and Laboratory Investigation, 2019
The aim of the study was to check whether measurement of TLR-2 in serum or cerebrospinal fluid (CSF) can help differentiate between neuroborreliosis (NB) and tick-borne encephalitis (TBE). Eighty patients with meningitis and meningoencephalitis were divided into two groups: Group I - patients with NB (n = 40) and Group II - patients with TBE (n = 40 ...
Moniuszko-Malinowska, Anna, Penza, Paweł, Pancewicz, Sławomir, Świerzbińska, Renata, Król, Monika, Zajkowska, Joanna, Czupryna, Piotr, Zajkowska, Olga, Dunaj, Justyna   +8 more
openaire   +4 more sources

Dysregulation of toll‐like receptor‐2 (TLR‐2)‐induced effects in monocytes from patients with atopic dermatitis: impact of the TLR‐2 R753Q polymorphism

Allergy, 2008
Background:  Atopic dermatitis (AD) is often complicated by an enhanced susceptibility to bacterial skin infections, especially with Staphylococcus aureus. Toll‐like receptors (TLR), especially TLR‐2 recognizes cell wall components of S. aureus, e.g. lipoteichoic acid (LTA) and peptidoglycan (PGN).
M, Niebuhr, J, Langnickel, C, Draing, H, Renz, A, Kapp, T, Werfel   +5 more
openaire   +2 more sources

Human neutrophils and TLRs: 2, 4, and plenty more

Blood, 2003
And who could be truly surprised? Toll-like receptors (TLRs) are orthologs of combined developmental polarization and host defense proteins identified in the fruit fly, Drosophila melanogaster , and respond to molecular motifs that are distinct and unique features of bacterial, fungal, and ...
openaire   +1 more source

TLR-2 is involved in airway epithelial cell response to air pollution particles

Toxicology and Applied Pharmacology, 2005
Primary cultures of normal human airway epithelial cells (NHBE) respond to ambient air pollution particulate matter (PM) by increased production of the cytokine IL-8, and the induction of several oxidant stress response genes. Components of ambient air PM responsible for stimulating epithelial cells have not been conclusively identified, although metal
Susanne, Becker, Lisa, Dailey, Joleen M, Soukup, Robert, Silbajoris, Robert B, Devlin   +4 more
openaire   +2 more sources

Ubiquitin-like protein MNSFβ regulates TLR-2-mediated signal transduction

Molecular and Cellular Biochemistry, 2012
Post-translational modification by monoclonal nonspecific suppressor factor β (MNSFβ) has been involved in the regulation of a variety of cellular processes. Previous studies have demonstrated that MNSFβ covalently binds to the intracellular pro-apoptotic protein Bcl-G and regulates TLR-4-mediated signal transduction. Recently, we found that MNSFβ also
Morihiko, Nakamura, Jun, Watanabe, Natsuko, Watanabe   +2 more
openaire   +2 more sources

TLR-2 gene Arg753Gln polymorphism is strongly associated with acute rheumatic fever in children

Journal of Molecular Medicine, 2005
The recently described family of toll-like receptors (TLRs) is a key player in host immunity by mediating inflammatory reactions against a wide range of pathogens. Mutations and polymorphisms in TLRs have revealed the importance of TLRs in human defence against diseases.
Berdeli, A, Ulger, Z, Celik, HA, Ozyurek, R, Aydin, H   +4 more
openaire   +4 more sources