Results 91 to 100 of about 11,832,408 (324)

Expanding Chemical Space of Nucleic Acid Nanoparticles for Tunable Antiviral‐Like Immunomodulatory Responses and Potent Adjuvant Activity

Advanced Functional Materials, EarlyView.
We introduce a nucleic acid nanoparticle (NANP) platform designed to be rrecognized by the human innate immune system in a regulated manner. By changing chemical composition while maintaining constant architectural parameters, we identify key determinants of immunorecognition enabling the rational design of NANPs with tunable immune activation profiles
Martin Panigaj, Hannah S. Newton, Jian Wang, Laxmi Pandey, Yelixza I. Avilla, Phong Nguyen, Morgan Chandler, Justin Halman, Yasmine Radwan, Stephanie Smith, Elijah Edmondson, Simone Difilippantonio, Chelsea Sanders, Bao Tran, Yongmei Zhao, Shaojun Xie, Edward Cedrone, Barry W. Neun, Meni Wanunu, Nikolay V. Dokholyan, Marina A. Dobrovolskaia, Kirill A. Afonin   +21 more
wiley   +1 more source

Acute brucella melitensis M16 infection model in mice treated with tumor necrosis factor-alpha inhibitors [PDF]

, 2015
Introduction: There is limited data in the literature about brucellosis related to an intracellular pathogen and anti-tumor necrosis factor alpha (anti-TNFα) medication.
Akalın, Ş., Demirkan, N., Ergin, Ç., Kutlu, Murat, Sayin-Kutlu, S., Zorbozan, O., Çobankara, V., Şahin, B., Şen-Türk, N.   +8 more
core   +1 more source

Redefining Therapies for Drug‐Resistant Tuberculosis: Synergistic Effects of Antimicrobial Peptides, Nanotechnology, and Computational Design

Advanced Healthcare Materials, EarlyView.
Antimicrobial peptide (AMP)‐loaded nanocarriers provide a multifunctional strategy to combat drug‐resistant Mycobacterium tuberculosis. By enhancing intracellular delivery, bypassing efflux pumps, and disrupting bacterial membranes, this platform restores phagolysosome fusion and macrophage function.
Christian S. Carnero Canales, Jessica Ingrid Marquez Cazorla, Renzo Marianito Marquez Cazorla, Aline Martins dos Santos, Jonatas Lobato Duarte, Letícia Oliveira Catarin Nunes, Túlio Custódio Reis, Lara Cerazi Salvador, Norival Alves Santos‐Filho, Rafael Miguel Sábio, Hélder A. Santos, Fernando Rogério Pavan   +11 more
wiley   +1 more source

Expression of TLR-4 in epithelial serous ovarian cancer

Korean Journal of Gynecologic Oncology, 2007
Objective : This study was to determine the expression of Toll-like receptor 4 (TLR-4) in ovarian serous adenocarcinoma tissues. Methods : TLR-4 expression was evaluated at the RNA level by real-time quantitative RT-PCR, in 24 fresh frozen ovarian serous adenocarcinoma tissues and 9 normal ovarian tissues.
Chel Hun Choi, Jeong Won Lee, Jung Joo Choi, Woo Young Kim, Tae Joong Kim, Je Ho Lee, Byoung Gie Kim, Duk Soo Bae   +7 more
openaire   +1 more source

Peripheral blood concentration of toll-like receptor-4 and its accuracy for prediction of postpartum performances of transition zebu (Bos indicus) cows

Indian Journal of Animal Sciences, 2021
In this study, we evaluated the peripheral concentrations of Toll-like receptors (TLR)-4 during transition period in relation to postpartum productive and reproductive performances of Deoni (zebu) cattle. Accuracy and threshold values of TLR-4 to predict
AYYASAMY MANIMARAN, PRATIK RAMESH WANKHADE, ARUMUGAM KUMARESAN, TAPAS K PATBANDHA, MUNIANDY SIVARAM, SAKTHIVEL JEYAKUMAR, DURAISAMY RAJENDRAN   +6 more
doaj   +1 more source

Microneedle Technology in Psoriasis Management: Mechanistic Insights, Technological Innovation, Clinical Progress, and Challenges

Advanced Healthcare Materials, EarlyView.
This review explores the evolving role of microneedle systems in psoriasis management, highlighting their potential for enhanced drug delivery, diagnosis, and disease monitoring. It also discusses unmet clinical needs for psoriasis management and technical challenges, while outlining strategic directions to advance microneedle integration into routine ...
Fatma Moawad, Yasmine Ruel, Roxane Pouliot, Davide Brambilla   +3 more
wiley   +1 more source

Autophagy protects monocytes from Wolbachia heat shock protein 60-induced apoptosis and senescence. [PDF]

PLoS Neglected Tropical Diseases, 2015
Monocyte dysfunction by filarial antigens has been a major mechanism underlying immune evasion following hyporesponsiveness during patent lymphatic filariasis. Recent studies have initiated a paradigm shift to comprehend the immunological interactions of
Vijayan Kamalakannan, Abijit Shiny, Subash Babu, Rangarajan Badri Narayanan   +3 more
doaj   +1 more source

TLR-4, TLR-5 and IRF4 are diagnostic markers of knee osteoarthritis in the middle-aged and elderly patients and related to disease activity and inflammatory factors

Experimental and Therapeutic Medicine, 2020
Expression and diagnostic value of serum toll-like receptor-4 (TLR-4), Toll-like receptor-5 (TLR-5) and interferon regulatory factor 4 (IRF4) in middle-aged and elderly patients with knee osteoarthritis (KOA) and their correlation with Interleukin 1β (IL-
W. Han, Xiu-min Chen, Xianyin Wang, Zhengri Shen, Xiaobing Wang, Zuo-feng Zhang, Huiru Wang   +6 more
semanticscholar   +1 more source

Immunity in society: diverse solutions to common problems [PDF]

, 2012
Understanding how organisms fight infection has been a central focus of scientific research and medicine for the past couple of centuries, and a perennial object of trial and error by humans trying to mitigate the burden of disease.
Babayan, S.A., Schneider, D.S.
core   +3 more sources

From RNA to DNA: How Cargo Identity Reprograms Lipid Nanoparticle Architecture and Function

Advanced Healthcare Materials, EarlyView.
The evolution of lipid nanoparticles (LNPs) spans from RNA‐LNPs, used in mRNA vaccines, to DNA‐LNPs, ideal for gene therapies. Emerging bionano architectures, decorated with DNA and plasma proteins, pave the way for advanced DNA‐based therapies that are more stable, targeted, and customizable.
Erica Quagliarini, Daniela Pozzi, Giulio Caracciolo   +2 more
wiley   +1 more source