Results 101 to 110 of about 13,006,177 (289)

Hyaluronan reduces inflammation in experimental arthritis by modulating TLR-2 and TLR-4 cartilage expression [PDF]

, 2011
Previous studies have reported that low molecular mass HA and highly polymerized HA respectively elicited pro- and anti-inflammatory responses by modulating the toll-like receptor 4 (TLR-4) and the TLR-2.
Salvatore Campo, Antonio Micali, Giuseppe M. Campo, Angela D'Ascola, D'Ascola, Angela, Calatroni, Alberto, Alberto Calatroni, Prestipino, Vera, Campo, Giuseppe M., Avenoso, Angela, Vaccaro, Mario, Vera Prestipino, Campo, Salvatore, Micali, Antonio, Mario Vaccaro, Angela Avenoso, Nastasi, Giancarlo, Giancarlo Nastasi   +17 more
core   +1 more source

Liquid‐Responsive Shape‐Memory Nanofiber‐Reinforced Scaffolds for Cartilage Repair

Advanced Science, EarlyView.
A liquid‐responsive shape‐memory, nanofiber‐reinforced QCG scaffold combines conformal defect filling, an aligned architecture that is structurally permissive for endogenous cell infiltration, and sustained KGN release. This integrated design enhances BMSC viability, migratory activity, and chondrogenic differentiation and promotes hyaline cartilage ...
Jiyang Zeng, Wei Li, Yawei Li, Zhiming Tu, Hong Ma, Yuliang Dai, Zhaoling Ma, Tao Yuan, Bing Wang   +8 more
wiley   +1 more source

Placental Trophoblast Responses to Porphyromonas gingivalis Mediated by Toll-like Receptor-2 and -4

Journal of Dentistry Indonesia, 2013
Trophoblast participates in preventing allorecognition and controlling pathogens that compromise fetal wellbeing. Toll-like receptors recognize conserved sequences on the pathogens surface and trigger effector cell functions.
Banun Kusumawardani, Marsetyawan HNE Soesatyo, Djaswadi Dasuki, Widya Asmara   +3 more
doaj   +1 more source

Subcellular organelle lipidomics in TLR-4-activated macrophages1[S]

Journal of Lipid Research, 2010
Lipids orchestrate biological processes by acting remotely as signaling molecules or locally as membrane components that modulate protein function. Detailed insight into lipid function requires knowledge of the subcellular localization of individual lipids.
Andreyev, Alexander Y, Fahy, Eoin, Guan, Ziqiang, Kelly, Samuel, Li, Xiang, McDonald, Jeffrey G, Milne, Stephen, Myers, David, Park, Hyejung, Ryan, Andrea, Thompson, Bonne M, Wang, Elaine, Zhao, Yihua, Brown, H Alex, Merrill, Alfred H, Raetz, Christian RH, Russell, David W, Subramaniam, Shankar, Dennis, Edward A   +18 more
openaire   +3 more sources

Compound Abrus cantoniensis Extract Alleviates AFB1‐Induced Liver Injury by Regulating PI3K‐AKT Pathway and Gut Microbiota/Butyrate Metabolism

Advanced Science, EarlyView.
ACCE has a good alleviating effect on AFB1‐induced liver injury, and this alleviating effect is related to the PI3K‐AKT pathway regulated by ACCE and the butyrate metabolism of gut microbiota. ABSTRACT Aflatoxin B1 (AFB1) is a potent hepatotoxin commonly ingested through contaminated food. Abrus cantoniensis Hance, a traditional Chinese medicinal herb,
Hongjie Hu, Ming cheng, Shiqi Zheng, Huixin Liu, Xiaofang Wei, Wenwen Yang, Hongchun Yang, Liuyang Yuan, Li Jiang, Jie Chen, Linglong Zhao, Yanchao Guo, Hongbin Si   +12 more
wiley   +1 more source

Immune Checkpoint Inhibitor as a Fifth Component of Lipid Nanoparticles Enables Lymph Node‐Targeting and Augments mRNA Vaccine Efficacy

Advanced Science, EarlyView.
Here, a PDL1 inhibitor is employed as a fifth component to modify lipid nanoparticles (LNPs). PDL1 inhibitor‐loaded LNPs show enhanced lymph node targeting, resulting in greater lymph node expansion, immune cell infiltration, and improved mRNA vaccine efficacy. This fifth component LNP could be a novel platform for mRNA vaccines.
Minki Ha, Jaehyun Kim, Seyoung Kim, Gonna Somu Naidu, Sungchan Cho, Seok‐Beom Yong   +5 more
wiley   +1 more source

Variability in Toll-like Receptor Genes and Their Relation to Occurrence of Periodontal Pathogens in Chronic Periodontitis

Česká Stomatologie a Praktické Zubní Lékařství, 2011
Introduction: Toll-like receptors (TLRs) belong to the pattern recognition receptor family of signal molecules that recognize heterogeneous antigens.
L. Izakovičová Hollá, B. Hrdličková, J. Vokurka, P. Augustín, A. Fassmann, J. Vaněk   +5 more
doaj   +1 more source

T‐Cell Remodeling in Renal Fibrosis: From Acute Injury to Chronic Kidney Disease

Advanced Science, EarlyView.
This Review presents renal fibrosis as a sequence of overlapping T‐cell programs, from chemokine‐guided recruitment and metabolic activation to maladaptive polarization, tertiary lymphoid structure formation, tissue residency, exhaustion, and senescence.
Qianhui Li, Junting Guan, Yifan Song, Hongxia Yang, Guangtao Li, Xiaodong Zhao, Jiaxin Liu, Bin Liu, Yang Tan, Honglan Zhou, Yang‐He Zhang, Yishu Wang   +11 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Hepatic and aortic mRNA expression of toll-like receptor (TLR)-2 and TLR-4.

, 2014
The baseline mRNA expressions of TLR-2 and TLR-4 were higher in the liver than in the aorta. Changes in mRNA expression in response to the cholesterol diet and/or carrageenan injection were substantially different between tissues. mRNA expressions of TLR-
Eung Ju Kim (573340), Hyun Hee Kim (456274), Baek-hui Kim (573341), Yong Jik Lee (573343), Hyun-Hwa Son (573344), Man Ho Choi (573345), Hong Seog Seo (573342)   +6 more
core   +1 more source