Results 91 to 100 of about 13,006,177 (289)

Increased Expression of Toll-Like Receptors 2 and 4 in Renal Transplant Recipients that Develop Allograft Dysfunction: A Cohort Study [PDF]

Iranian Journal of Immunology, 2017
Background: The incidence of ischemic reperfusion injury (IRI) in early phase post-transplantation and activation of toll-like receptor (TLR-2) and TLR-4 remarkably impact the outcome of a renal allograft. Objective: To investigate whether the expression
Morteza Hosseinzadeh, Mohsen Nafar, Pedram Ahmadpoor, Farshid Noorbakhsh, Mir Saeed Yekaninejad, Mohammad Hossein Niknam, Aliakbar Amirzargar   +6 more
doaj  

Mitochondria‐Targeted Nanotherapeutics: A Promising Strategy in Modulating Mitochondrial Function, Transfer, and Transplantation

Advanced Science, EarlyView.
This review summarizes the pathogenic role of mitochondria in diseases and highlights mitochondrial transfer and transplantation as emerging therapeutic strategies. It systematically discusses how nanomaterials are engineered to facilitate these processes, and critically examines the current challenges and future perspectives for their clinical ...
Yuanyuan Su, Zhiyan Gong, Jiao Mu, Lili Huang, Pengfei Yang, Chenli Zhang, Lingshan Zhao, Liling Yang, Jun Deng, Xiaohui Liao   +9 more
wiley   +1 more source

Toll-like Receptor 4/Nuclear Factor-κB Signaling in Synovial Tissue Is Involved in the Anti-inflammatory Effect of Moxibustion in Rats with Rheumatoid Arthritis

针刺研究, 2018
Objective To observe the effect of moxibustion on Toll-like receptor 4/nuclear factor-κB(TLR 4/NF-κB)signaling in the synovial tissue of the ankle joint in rats with rheumatoid arthritis(RA),so as to analyze its biological mechanism underlying ...
ZHANG Chuan-ying, HU Ling, CAI Rong-lin, PENG Chuan-yu, YUAN Juan   +4 more
doaj   +2 more sources

Efficacy of specific prevention of influenza in individuals with polymorphisms Arg753Gln of TLR-2, Leu412Phe of TLR-3, Asp299gly of TLR-4 genes

, 2020
The aim: is to study the efficacy of influenza vaccination for individuals with polymorphism Arg753Gln of TLR-2 gene, Leu412Phe of TLR-3 gene, and Asp299Gly of TLR-4 gene. Materials and methods: 66 people with mutant genotypes and normal distribution of
Pryimenko, N. O., Руденко, Станіслав Станіславович, Kotelevska, T. M., Syzova, L. M., Боднар, Вадим Анатолійович, Koval, T. I., Котелевська, Тетяна Михайлівна, Rudenko, S. S., Прийменко, Наталія Олегівна, Коваль, Тетяна Ігорівна, Bodnar, V. A., Сизова, Людмила Михайлівна   +11 more
core   +1 more source

Matrix Rigidity Mechanoprimes Microglia for Inflammation Through Cytoskeletal‐to‐Nuclear Signaling and 3D Spatio‐Epigenomic Remodeling

Advanced Science, EarlyView.
Pathological tissue rigidity mechanoprimes microglia by enhancing actin cytoskeleton–nucleus coupling and chromatin opening at rigidity‐responsive cis‐regulatory elements (mechanoCREs). Subsequent NF‐κB/p65 signaling converges on this permissive regulatory state to amplify inflammatory gene expression and microglial activation.
Yu Xuan Meng, Jaegeon Joo, Yu Meng Li, Cheng Ji Li, Ali Taghizadeh, Seung Jae Shin, Buuvee Bayarkhangai, Tae‐Woo Ha, Sak Lee, Jaewoo Chung, Bo‐Eun Yoon, Hye Sung Kim, Inkyung Jung, Jung‐Hwan Lee, Kam W. Leong, Hae‐Won Kim   +15 more
wiley   +1 more source

Fig. 6a - 3D Protein Model of TLR-4

, 2023
A 3D model of mus musculus TLR-4 in Chimera as predicted by AlphaFold. The LRR domain is shown in red and the TIR domain is shown in blue. Regions of positive selection are shown in yellow. 
Jakob Luce (14787307), Isabelle Willoughby (14791471), Juan Torres (14792086), Emily Buak (14785927)   +3 more
core   +1 more source

Beyond Probiotics: Postbiotics for Healthy Aquaculture

Advanced Science, EarlyView.
This critical review assesses limitations of probiotics and proposes postbiotics, preparations of inanimate microorganisms and their metabolites, as a more stable, controlled, and biosafe formulation. Postbiotics offer significant advantages during industrial aquafeed production and storage. However, their practical implementation is currently hindered
Michael Leonidas Chikindas, Delin Xu, Igor V. Popov, Kayque Ordonho Carneiro, Nilufar Arashovna Elova, Gullola Amirovna Bekmurodova, Dildora Amindjanovna Amirsaidova, Astghik Pepoyan, Shakhlo Mirjamalovna Miralimova, Oleg V. Mitrokhin, Liubov S. Sichel, John Tagg, Svetoslav Dimitrov Todorov   +12 more
wiley   +1 more source

Effect of pioglitazone on neuropathic pain and spinal expression of TLR-4 and cytokines

Experimental and Therapeutic Medicine, 2016
The molecular mechanisms underlying neuropathic pain have yet to be elucidated. The present study aimed to examine the modulation of neuroimmune activation in the spinal cord by the synthetic peroxisome proliferator-activated receptor gamma (PPAR-γ) agonist, pioglitazone (Pio), in a rat model of neuropathic pain induced by chronic constriction injury ...
Hongbin, Jia, Shuangshuang, Xu, Qingzhen, Liu, Jian, Liu, Jianguo, Xu, Weiyan, Li, Yi, Jin, Qing, Ji   +7 more
openaire   +3 more sources

Dual‐Targeted Biomimetic MoSe2 Nanozymes for Enhancing Peri‐Implant Soft Tissue Integration

Advanced Science, EarlyView.
A dual‐targeting biomimetic nanozyme, MoSe2@SPMM, selectively targets Staphylococcus aureus and oxidatively stressed macrophages. Near‐infrared activation couples contact‐enhanced photothermal bacterial eradication with reactive oxygen species scavenging to disrupt the pathogenic–immunological amplification loop.
Minghao Zhou, Miaomiao Tian, Jingwei Yu, Jiaxin Kang, Miaomiao Chen, Yue Yuan, Lizhi Liu, Hongbo Wei   +7 more
wiley   +1 more source

Propolis immunomodulatory activity on TLR-2 and TLR-4 expression by chronically stressed mice

, 2012
Our group has been investigating the immunomodulatory activity of propolis in stressed mice. In this work, we wish to report the action of propolis in chronically stressed mice, assessing the Toll-like receptor (TLR2 and TLR-4) expression by spleen cells
José Maurício Sforcin, Cláudio Lera Orsatti, Orsatti, Claudio Lera [UNESP], Sforcin, Jose Mauricio, Orsatti, Claudio Lera, Sforcin, Jose Mauricio [UNESP]   +5 more
core   +1 more source