Results 121 to 130 of about 136,864 (160)

HMGB1 SIGNALS THROUGH TOLL-LIKE RECEPTOR (TLR) 4 AND TLR2

Shock, 2006
In response to bacterial endotoxin (e.g., LPS) or endogenous proinflammatory cytokines (e.g., TNF and IL-1beta), innate immune cells release HMGB1, a late cytokine mediator of lethal endotoxemia and sepsis. The delayed kinetics of HMGB1 release makes it an attractive therapeutic target with a wider window of opportunity for the treatment of lethal ...
Man, Yu, Haichao, Wang, Aihao, Ding, Douglas T, Golenbock, Eicke, Latz, Christopher J, Czura, Matthew J, Fenton, Kevin J, Tracey, Huan, Yang   +8 more
openaire   +2 more sources

Inhibition of TLR-4/MD-2 signaling by RP105/MD-1

Journal of Endotoxin Research, 2005
Activation of Toll-like receptor (TLR) signaling by microbial and host molecular signatures is critical to the induction of immune responses. Such signaling is, perforce, kept under tight control. We recently discovered a novel endogenous inhibitor of TLR-4 — RP105.
Senad, Divanovic, Aurelien, Trompette, Sowsan F, Atabani, Rajat, Madan, Douglas T, Golenbock, Alberto, Visintin, Robert W, Finberg, Alexander, Tarakhovsky, Stefanie N, Vogel, Yasmine, Belkaid, Evelyn A, Kurt-Jones, Christopher L, Karp   +11 more
openaire   +2 more sources

TLR-4 GENE POLYMORPHISM IN RENAL TRANSPLANT PATIENTS [PDF]

, 2013
The study included 70 patients with a transplanted kidney and 50 healthy volunteers representing a control group. Median age of the transplanted patients was 53 years (48-58 years). Transplanted patients had been receiving an adjuvant kidney therapy for an average of 4 years (2-6 years).
Glavaš, Josipa, Sesar, Sanda, Alkhamis, Tamara, Kralik, Kristina, Prlić, Damir, Barbić, Jerko   +5 more
openaire   +2 more sources

Imidacloprid induced histomorphological changes and expression of TLR-4 and TNFα in lung

Pesticide Biochemistry and Physiology, 2016
The imidacloprid is used worldwide as a pesticide and has been linked with endocrine disturbances and reduced pulmonary function. However, effects of imidacloprid alone or in combination with microbial molecules on lungs are not fully understood. Because the pulmonary effects of interactions of endotoxins with imidacloprid are unknown, we designed a ...
Arif Ahmad, Pandit, Shanti, Choudhary, , Ramneek, Baljit, Singh, R S, Sethi   +4 more
openaire   +2 more sources

Immune Response Against Sporothrix schenckii in TLR-4-Deficient Mice

Mycopathologia, 2012
For many fungal diseases, macrophages are the major cell population implicated in host protection, primarily by their ability to eliminate the invading fungal pathogen through phagocytosis. In sporotrichosis, this remains true, because of macrophages’ ability to recognize Sporothrix schenckii through specific receptors for some of the fungus’ cellular ...
Sassa, Micheli Fernanda, Ferreira, Lucas Souza, de Abreu Ribeiro, Livia Carolina, Carlos, Iracilda Zeppone   +3 more
openaire   +3 more sources

Shock-induced neutrophil mediated priming for acute lung injury in mice: divergent effects of TLR-4 and TLR-4/FasL deficiency.

The American journal of pathology, 2003
Acute lung injury (ALI) leading to respiratory distress is a common sequela of shock/trauma, however, modeling this process in mice with a single shock or septic event is inconsistent. One explanation is that hemorrhage is often just a "priming insult," thus, secondary stimuli may be required to "trigger" ALI.
Alfred, Ayala, Chun-Shiang, Chung, Joanne L, Lomas, Grace Y, Song, Lesley A, Doughty, Stephen H, Gregory, William G, Cioffi, Brian W, LeBlanc, Jonathan, Reichner, H Hank, Simms, Patricia S, Grutkoski   +10 more
openaire   +1 more source

Mechanistic insights on TLR-4 mediated inflammatory pathway in neurodegenerative diseases

Pharmacological Reports
Neurodegenerative diseases (NDDs) pose a significant issue in healthcare, needing a thorough knowledge of their complex molecular mechanisms. A diverse set of cell signaling mediators and their interactions play critical roles in neuroinflammation. The release of pro-inflammatory mediators in response to neural dysfunction is detrimental to normal cell
Veerta Sharma, Prateek Sharma, Thakur Gurjeet Singh   +2 more
openaire   +2 more sources

“Monovalent” ligands that trigger TLR-4 and TCR are not necessarily truly monovalent

Molecular Immunology, 2012
Cell surface receptors mediate many cellular responses in health and disease. Recent progress in our understanding of how ligand binding to the extracellular domains of receptors triggers intracellular signaling has underlined the role of ligand-promoted receptor clustering following by oligomerization of the cytoplasmic signaling domains.
openaire   +2 more sources

An Overview of Recent Insights into the Response of TLR to SARS-CoV-2 Infection and the Potential of TLR Agonists as SARS-CoV-2 Vaccine Adjuvants

Viruses, 2021
Kyoko Tsukiyama-Kohara, Michinori Kohara, Kyoko Tsukiyama-Kohara   +2 more
exaly  

TLR/WNT: A Novel Relationship in Immunomodulation of Lung Cancer

International Journal of Molecular Sciences, 2022
Antonia Obrador, Hanaa Shafiek, Amanda Iglesias   +2 more
exaly