Results 131 to 140 of about 154,777 (303)

Genetic prediction of blood cell reactivity and its potential causal influence on bone continuity and density disorders

Animal Models and Experimental Medicine, EarlyView.
We applied Mendelian randomization to explore causal links between blood cell traits and skeletal disorders. Using genetic instruments from large‐scale summary statistics, we assessed effects on bone continuity, density, and structural integrity. Sensitivity and reverse analyses confirmed robust associations, highlighting potential shared biological ...
Zhiqin Deng, Zhe Zhao, Wenting Jiang, Xiaoqiang Chen, Jianquan Liu, Xu Tao, Zhengyang Lin, Zhenhan Deng, Wencui Li   +8 more
wiley   +1 more source

Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus

Journal of Immunology Research, 2015
Systemic lupus erythematosus is characterized by dysregulated activation of T and B cells and autoantibodies to nuclear antigens and, in some cases, lipid antigens.
Carlos Wong-Baeza, Alonso Tescucano, Horacio Astudillo, Albany Reséndiz, Carla Landa, Luis España, Jeanet Serafín-López, Iris Estrada-García, Sergio Estrada-Parra, Leopoldo Flores-Romo, Carlos Wong, Isabel Baeza   +11 more
doaj   +1 more source

Porcine kidney xenotransplantation: From primate models to clinical reality

Animal Models and Experimental Medicine, EarlyView.
In the face of a critical shortage of human donor kidneys for end‐stage renal disease patients, porcine kidney xenotransplantation has emerged as a viable solution. This field has navigated major hurdles, including immune rejection, physiological incompatibilities, potential biomechanical differences and the risk of cross‐species infection. To overcome
Zihang Guo, Ling Zhang, Shoulong Deng, Chuan Qin   +3 more
wiley   +1 more source

بررسی تأثیر ابتلا به پریودنتیت مزمن بر میزان بیان ژن TLR-2 و TLR-4 در بافت لثه ای [PDF]

Journal of Mashhad Dental School, 2011
مقدمه: در عفونت‏های پریودنتال پیش نیاز شروع پاسخ‏های میزبان، شناخت پاتوژن‏‏ها توسط سیستم ایمنی میزبان می‏باشد. خانواده رسپتور‏های Toll-like (TLRs)، مسئول شناسایی ساختار‏های حفظ شده میکروبیال نظیر لیپوپلی ساکارید (LPS) باکتری‏ها می‏باشند و مسیر‏های سیگنال
کاظم فاطمی, مهرداد رادور, عبدالرحیم رضایی, حمیدرضا عرب, هوشنگ رفعت پناه, حسن آذان گو خیاوی, یلدا دادپور   +6 more
doaj  

Immune responses induced by the TLR-4 agonist-based adjuvant prothymosin alpha.

Journal of Clinical Oncology, 2014
11131 Background: The immunomodulator prothymosin α (proTα) stimulates immune subpopulations via generating an optimized cytokine milieu.
Samara, Pinelopi, Ioannou, Kyriaki, Kavrohorianou, Nadia, Voutsas, Ioannis F., Kappa, Niki, Williams, Evangelia, Haralambous, Sylva, Tsitsilonis, Ourania E.   +7 more
openaire   +2 more sources

Chronic alcohol consumption compromises gut barrier integrity and promotes endotoxemia: Implications for sepsis susceptibility in immunocompromised hosts

Animal Models and Experimental Medicine, EarlyView.
Chronic alcohol exposure disrupts intestinal barrier integrity, resulting in a leaky gut and enhanced translocation of lipopolysaccharide (LPS) and microbial products into the systemic circulation. Alcohol‐induced endotoxemia drives exaggerated pro‐inflammatory responses, mitochondrial damage, and activation of the cGAS–STING pathway, particularly in ...
Thansita Bhunyakarnjanarat, Chatsuree Suksamai, Dhammika Leshan Wannigama, Kent Doi, Wiwat Chancharoenthana, Asada Leelahavanichkul   +5 more
wiley   +1 more source

Cold Gas Plasma Induces Platelet Activation and Hemostasis in Native and Anticoagulated Human Blood

Advanced NanoBiomed Research, EarlyView.
Cold physical gas plasma induces platelet activation and hemostatic responses in native and anticoagulated human blood. Treatment efficacy depends on plasma parameters, including gas composition, distance, and exposure mode, which govern reactive species delivery and energy transfer.
Sander Bekeschus, Broder Poschkamp, Lea Miebach, Anke Schmidt, Linus Hübner, Julia van der Linde   +5 more
wiley   +1 more source

ROLE OF INHERENT IMMUNITY AND MICROORGANISMS OF BIOTOPES OF MUCOUS MEMBRANE OF WOMEN’S GENITOURINARY TRACT IN PATHOGENESIS OF CHLAMYDIA INFECTION

Сеченовский вестник, 2010
Aim. Study of Toll-like receptors (TLR) role and microorganisms of bioptopes of genitourinary tract in pathogenesis of genitourinary chlamydiasis.Methods.
M. S. Afanasiev, A. V. Karaulov, V. A. Aleshkin, S. S. Afanasiev, Yu. V. Nesvizhsky, E. A. Voropaeva   +5 more
doaj  

Cancer vaccines: uses of HLA transgenic mice compared to genetically modified mice [PDF]

, 2008
Many tumor antigens have been identified that can be targeted by the immune system. Animal models that have been genetically modified to express human HLA molecules instead of their own MHC antigens have shown to be valuable in the discovery of peptides ...
McArdle, SE
core  

Dietary Mannan‐Rich Fractions Attenuate Weaning Stress in Piglets via Modulating Gut Microbiota and TLR5/NF‐κB Signaling

Animal Research and One Health, EarlyView.
This study aimed to investigate the potential of a mannan‐rich fraction (MRF) as a dietary intervention to alleviate weaning stress in piglets. Our results revealed that MRF could alleviate weaning stress by modulating the gut microbiota and the TLR5/NF‐κB signaling pathway, offering a novel and sustainable alternative to antibiotic use in swine ...
Yutong Lu, Yiwei Sun, Kun Cai, Pingli He, Gang Lin, Zengkai Qi, Hu Liu, Junshu Yan, Ning Ma   +8 more
wiley   +1 more source