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Вавиловский журнал генетики и селекцииModern research shows that innate immunity plays an important role in the pathogenesis of primary open-angle glaucoma (POAG). An increase in the content of toll-like receptors (TLR) in the glaucomatous retina of the human eye was revealed.
A. V. Shevchenko +4 more
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Seminars in Immunology, 2006 Mammalian Toll-like receptors (TLRs) play a critical role in detection of invading pathogens as well as triggering of subsequent inflammatory and immune responses. Each TLR recognizes distinct microbial components and activates different signaling pathways by selective utilization of adaptor molecules.
Taro, Kawai, Shizuo, Akira
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TLR-based immune adjuvants [PDF]
Vaccine, 2011 This work describes the nature and strength of the immune response induced by various Toll-like receptor ligands and their ability to act as vaccine adjuvants. It reviews the various ligands capable of triggering individual TLRs, and then focuses on the efficacy and safety of those agents for which clinical results are available.
Folkert, Steinhagen +3 more
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TLRs and chronic inflammation [PDF]
The International Journal of Biochemistry & Cell Biology, 2010 After the discovery of Toll-like receptors (TLRs), innate immune mechanisms came back in the focus of scientific research. With more and more mechanisms of TLR biology known, it has become clear that these and also other innate immune receptors are not only of crucial importance in the immune response to invading pathogens, but also play a role in the ...
Ospelt, C, Gay, S
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TLR Ignores Methylated RNA? [PDF]
Immunity, 2005 CpG methylation of DNA silences TLR9-mediated innate immune recognition. In this issue of Immunity, Kariko et al (2005) suggest that the innate immune recognition of RNA by TLR3, TLR7, or TLR8 is in fact controlled by modification of nucleotides, including methylation.
Ishii, Ken J., Akira, Shizuo
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Protein phosphatases in TLR signaling [PDF]
Cell Communication and Signaling, 2021 AbstractToll-like receptors (TLRs) are critical sensors for the detection of potentially harmful microbes. They are instrumental in initiating innate and adaptive immune responses against pathogenic organisms. However, exaggerated activation of TLR receptor signaling can also be responsible for the onset of autoimmune and inflammatory diseases.
Clovis H. T. Seumen +2 more
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Эпидемиология и вакцинопрофилактика, 2018 Vaccines for many years act as one of the most effective and successfully used medicines. Vaccines obtained by traditional methods contain in their composition live, weakened or killed microorganisms (bacteria, viruses, etc.).
O. A. Svitich +5 more
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Autoimmunity, 2021 Toll-like receptors (TLRs) are known to have an important role in triggering the innate immune response and in priming antigen-specific adaptive immunity and inflammation. The differences in synovial tissue expression of the TLRs between seronegative and
Alzahraa Abdelwahab +10 more
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Immunity, 2016 Two new studies published in The American Journal of Human Genetics (Dannemann et al., 2016; Deschamps et al., 2016) show that introgression of innate immune genes from Neandertals and Denisovans contributed to the modern genome of European and Asian, but not African, populations, and this might partly explain differences in susceptibility to immune ...
Netea, M.G., Joosten, L.A.B.
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Neisserial PorB immune enhancing activity and use as a vaccine adjuvant
Human Vaccines & Immunotherapeutics, 2019 Our laboratory has focused on Porin B (PorB), an outer membrane protein from Neisseria meningitidis and TLR2 ligand-based adjuvant, to characterize specific molecular and cellular pathways involved in improved immune responses induced by vaccine ...
Rachel Yuen +3 more
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