Results 141 to 150 of about 19,241 (251)
The impact of respiratory virus infections on global health is felt not just during a pandemic, but endemic seasonal infections pose an equal and ongoing risk of severe disease. Moreover, vaccines and antiviral drugs are not always effective or available
Georgia Deliyannis (87786) +18 more
core
Megakaryocyte TLR2: immunity bullet?
, 2011 Innate immunity is the host defensive weapon against pathogens and this issue of Blood offers an interesting new bullet for the immune system gun by studying the role of Toll-like receptor 2 (TLR2) in megakaryocytic function; a field previously not ...
PIGNATELLI, Pasquale +3 more
core +1 more source
From haemostasis to immunity: The expanding frontiers of platelet biology
British Journal of Haematology, EarlyView.Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley +1 more source
Gut microbiota as a novel therapeutic target for eating disorders and obesity
British Journal of Pharmacology, EarlyView.The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė +5 more
wiley +1 more source
, 2008 학위논문(박사) - 한국과학기술원 : 화학과, 2008. 8., [ xi, 117 p. ]TLR2 in complex with TLR1 or TLR6 plays an important role in innate immune response by recognizing microbial lipoproteins and lipopeptides.
진미선, Jin, Mi-Sun
core +1 more source
EPHX2 Loss Promotes CRC Migration via EET‐Dependent Chemokine Elevation and Mitochondrial Defect
Cancer Science, EarlyView.Loss of EPHX2 promotes EET accumulation, which in turn enhances CXCL and ROS production, thereby promoting the migratory and invasive abilities of CRC cells. ABSTRACT Epoxide hydrolase 2 (EPHX2) is a key enzyme in fatty acid metabolism that metabolizes epoxyeicosatrienoic acids (EETs), lipid mediators involved in inflammation, angiogenesis, and ...
Jianjun Zhu +10 more
wiley +1 more source
Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens
Cell Proliferation, EarlyView.In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu +8 more
wiley +1 more source
Analysis of TLR2 expression on NK cells.
, 2014 (A) Representative flow CD56+/CD3- expression in membranes of NK cells; right image: NK cells were gated and analyzed for TLR2 (TLR2+/CD56+) expression. (B) Representative histograms showing the MFI levels of TLR2 expression on NK cells from control and ...
Ingeborg Becker (35763) +5 more
core +1 more source
International Journal of Cosmetic Science, EarlyView.GA text A 30% Picea abies resin extract cream combined antimicrobial, anti‐inflammatory and early pro‐repair activities relevant to acne‐prone skin. The formulation showed strong activity against Cutibacterium acnes, reduced inflammatory cytokines and demonstrated promising tolerability and efficacy in an exploratory in‐use study. Abstract Objective To
Simone Parrotta +4 more
wiley +1 more source
International Endodontic Journal, EarlyView.ABSTRACT Aim To evaluate CD68 and F4/80 glycoproteins in the worsening of apical periodontitis (AP) and liver fibrosis (LF) in Wistar rats. Methodology Thirty‐two Wistar rats were distributed in the following groups (n = 8): C—control; AP—apical periodontitis; LF—liver fibrosis; APLF—AP and LF.
L. V. Barroti +9 more
wiley +1 more source