Results 121 to 130 of about 19,241 (251)

Renal-associated TLR2 mediates ischemia/reperfusion injury in the kidney [PDF]

, 2005
TLRs are conserved pattern recognition receptors that detect motifs of pathogens and host material released during injury. For unknown reasons, renal TLR2 mRNA is mainly expressed by tubular cells and is enhanced upon renal ischemia/reperfusion (I/R ...
Geurt Stokman, Nike Claessen, Weening, Jan J., Claessen, Nike, van der Poll, T., Kirschning, C.J., Jan J. Weening, Florquin, S., Leemans, Jaklien C., Stokman, Geurt, Claessen, N., Florquin, Sandrine, Kirschning, Carsten J., Rouschop, K.M.A., Akira, S., Rouschop, Kasper M., Tom van der Poll, Teske, Gwendoline J. D., Weening, J.J., Shizuo Akira, Jaklien C. Leemans, Teske, G.J.D., Kasper M. Rouschop, van der Poll, Tom, Leemans, J.C., Gwendoline J.D. Teske, Carsten J. Kirschning, Sandrine Florquin, Akira, Shizuo, Stokman, G.   +29 more
core   +2 more sources

TLR2 Controls Intestinal Carcinogen Detoxication by CYP1A1

PLoS ONE, 2012
Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR ...
Do, Khoa Nguyen, Fink, Lisbeth Nielsen, Jensen, Thomas Elbenhardt, Gautier, Laurent, Parlesak, Alexandr   +4 more
openaire   +6 more sources

Adaptive Immunity in Marsupials

Journal of Experimental Zoology Part A: Ecological and Integrative Physiology, EarlyView.
Comparison of the marsupial and eutherian adaptive immune systems. ABSTRACT Marsupials diverged from eutherian mammals 125–160 million years ago. Although evolutionarily distinct, both groups of mammals can produce complex adaptive immune responses to antigens with several key differences.
Cassandra L. Jol, Hayley J. Stannard, Julie M. Old   +2 more
wiley   +1 more source

Adjuvant TACE inhibitor treatment improves the outcome of TLR2^-/- mice with experimental pneumococcal meningitis [PDF]

, 2007
Background Streptococcus (S.) pneumoniae meningitis has a high lethality despite antibiotic treatment. Inflammation is a major pathogenetic factor, which is unresponsive to antibiotics.
Stephen L Leib, Leib Stephen L, Echchannaoui Hakim, Neumann, Ulf, Landmann, Regine M. A., Leib, Stephen L., Ulf Neumann, Regine MA Landmann, Echchannaoui, Hakim, Neumann Ulf, Landmann Regine MA, Hakim Echchannaoui   +11 more
core   +3 more sources

Periodontitis and gastric disorders: Systematic review and meta‐analysis of functional dyspepsia and Helicobacter pylori gastritis

Journal of Periodontology, EarlyView.
Abstract Background Periodontitis has been associated with other systemic inflammatory diseases, such as cardiovascular disease, diabetes mellitus, and rheumatoid arthritis; through the translocation of oral bacteria and local inflammatory mediators systemically.
Hadeel Mohammed Abbood, Jasim Mohammed Abbood, Ekin Yay‐Kus, Iain L. C. Chapple   +3 more
wiley   +1 more source

Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice

陆军军医大学学报
Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs.
CHENG Hao, YANG Yun, SUN Hongwu
doaj   +1 more source

Advances in research on autophagy in the maintenance of insect–microbe symbiosis

New Plant Protection, EarlyView.
Autophagy plays a dual regulatory role in insect–microbe symbiotic relationships. Beneficial symbiotic bacteria in insects participate in nutrient exchange via the TOR pathway, whereas pathogenic microbes induce immune defense through the AMPK pathway. Autophagy‐related genes regulate development and pathogen clearance during this process.
Yanbin Wang, Yuqiong Hao, Ke Chen, Hongbin Zhang, Xiansheng Xie, Feirong Ren   +5 more
wiley   +1 more source

TLR2 siRNA treatment decreases TLR2 gene expression in uninfected and M. abscessus -infected A549 cells.

, 2013
As a first step in assessing the role of TLR2 in respiratory epithelial responses to M. abscessus, the effect of transfection of A549 cells with TLR2 siRNA on TLR2 gene expression was assessed.
Lisa B. Davidson (336990), Thomas F. Byrd (336993), Prakasha Kempaiah (336992), Rachid Nessar (336991), Douglas J. Perkins (155948)   +4 more
core   +1 more source

Deciphering the Inflammatory Network in Pediatric Recurrent Tonsillitis: The Role of TRAF6, IRAK1, and miR‐146a‐5p

Otolaryngology–Head and Neck Surgery, EarlyView.
Abstract Objective To investigate the role of TNF receptor‐associated factor 6 (TRAF6), interleukin 1 receptor‐associated kinase 1 (IRAK1), and miR‐146a‐5p expression levels in the pathogenesis of recurrent tonsillitis. Study Design Case‐control study. Setting The study was conducted at the Department of Otorhinolaryngology, Muğla Training and Research
Ömer Faruk Güzel, Çilem Özdemir, Tuba Edgünlü, Ozan Gökdoğan   +3 more
wiley   +1 more source

miR-328-3p targets TLR2 and down-regulates TLR2 expression after OGD treatment.

A. 3’-UTR of TLR2 mRNA was predicted to be targeted by miR-328-3p. B. Dual-luciferase reporter assay detects the binding of TLR2 and miR-328-3p (n = 3). C. qRT-qPCR analyzed the mRNA expression level of TLR2 in each group (n = 3). D.
Zilong Wang (404828), Tianting Guo (17090890), Jianwen Mo (284487), Dongwen Wu (4240525), Mengting Yao (11089824), Chucun Fang (18017846), Jian Wu (41301), Jiacheng Ma (1530640)   +7 more
core   +1 more source