Results 121 to 130 of about 152,328 (305)

Active Components of Leptospira Outer Membrane Protein LipL32 to Toll-Like Receptor 2

Scientific Reports, 2017
Proteins belonging to the toll-like receptor (TLR) family, particularly TLR2, are the major components of innate immunity against Leptospira infection.
Shen-Hsing Hsu, Cheng-Chieh Hung, Ming-Yang Chang, Yi-Ching Ko, Huang-Yu Yang, Hsiang-Hao Hsu, Ya-Chung Tian, Li-Fang Chou, Rong-Long Pan, Fan-Gang Tseng, Chih-Wei Yang   +10 more
doaj   +1 more source

Innate immune response in avian macrophages elicited by Chlamydia psittaci [PDF]

, 2015
Chlamydia psittaci is a gram-negative, obligate, intracellular bacterium, which mainly infects birds and mammals. Not much is known about innate immunity initiated by C. psittaci.
Lagae, Stefanie, Vanrompay, Daisy
core  

The Role of Endothelin‐1 in Autoimmune Diseases: Mechanistic Insights and Therapeutic Targets

iNew Medicine, EarlyView.
The Role of Endothelin‐1 in Autoimmune Diseases. NF‐κB: nuclear factor kappa‐B; MAPK: mitogen‐activated protein kinase; PI3K: phosphoinositide 3‐kinase; ROS: reactive oxygen species; CTGF: connective tissue growth factor; TGF‐β: transforming growth factor‐β.
Xun Gong, Zhenyu Wang, Suyin Yang, Kaige Gao, Xin Yang, Min Tang   +5 more
wiley   +1 more source

Involvement of Toll-like receptor 2 in the cerebral immune response and behavioral changes caused by latent Toxoplasma infection in mice.

PLoS ONE, 2019
Subacute and chronic infections with the intracellular protozoan parasite Toxoplasma gondii are associated with an increased risk of psychiatric diseases like schizophrenia. However, little is known about the mechanisms involved in T.
Fumiaki Ihara, Sachi Tanaka, Ragab M Fereig, Maki Nishimura, Yoshifumi Nishikawa   +4 more
doaj   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Baicalin Attenuates Mycoplasma gallisepticum-Induced Inflammation via Inhibition of the TLR2-NF-κB Pathway in Chicken and DF-1 Cells

Infection and Drug Resistance, 2019
Zhiyong Wu,1,* Chunli Chen,1,* Yusong Miao,1 Yuhao Liu,1 Qiaomei Zhang,1 Rui Li,1 Liangjun Ding,1 Muhammad Ishfaq,1 Jichang Li1,2 1College of Veterinary Medicine, Northeast Agricultural University, Harbin 150030, People’s Republic of China ...
Wu Z, Chen C, Miao Y, Liu Y, Zhang Q, Li R, Ding L, Ishfaq M, Li J   +8 more
doaj  

Infection and RNA-seq analysis of a zebrafish tlr2 mutant shows a broad function of this toll-like receptor in transcriptional and metabolic control and defense to Mycobacterium marinum infection

BMC Genomics, 2019
Background The function of Toll-like receptor 2 (TLR2) in host defense against pathogens, especially Mycobacterium tuberculosis (Mtb) is poorly understood.
Wanbin Hu, Shuxin Yang, Yasuhito Shimada, Magnus Münch, Rubén Marín-Juez, Annemarie H. Meijer, Herman P. Spaink   +6 more
doaj   +1 more source

Role of TLR2 in lung angiogenesis

The FASEB Journal, 2009
After chronic left pulmonary artery ligation (LPAL) in mice, there is rapid neovascularization of the ischemic lung. We showed increased macrophage‐derived growth factors and a positive correlation between the number of lavaged macrophages and the magnitude of angiogenesis.
Aigul Moldobaeva, Julie Nijmeh, John Jenkins, Elizabeth Wagner   +3 more
openaire   +1 more source

Probiotic‐based strategies in vulvovaginal candidiasis management: A comprehensive review of mechanisms and future directions

Interdisciplinary Medicine, EarlyView.
This review focuses on vulvovaginal candidiasis (VVC), examining its epidemiology, the pathogenesis of Candida albicans, and its relationships with vaginal microbiota. It comprehensively reviews probiotic‐based management strategies and their mechanisms of action, and concludes by discussing current limitations, challenges and future research ...
Tong Chen, Yuwei Wu, Ya Chen, Ying Li, Hui Zhao, Lei Wu, He Gao, Tong Jiang, Xiaohong Wang, Moutong Chen, Jumei Zhang, Xinqiang Xie, Tingting Liang, Qingping Wu   +13 more
wiley   +1 more source

TLR2 signaling is required for the innate, but not adaptive response to LVS clpB

Frontiers in Immunology, 2014
Toll-like receptor 2 (TLR2) is the best characterized pattern-recognition receptor for the highly pathogenic intracellular bacterium, Francisella tularensis.
Lydia Marie Roberts, Hannah E Ledvina, Gregory eSempowski, Jeffrey eFrelinger   +3 more
doaj   +1 more source