Results 111 to 120 of about 152,328 (305)

RNA interference screening reveals host CaMK4 as a regulator of cryptococcal uptake and pathogenesis [PDF]

, 2017
Cryptococcus neoformans , the causative agent of cryptococcosis, is an opportunistic fungal pathogen that kills over 200,000 individuals annually. This yeast may grow freely in body fluids, but it also flourishes within host cells.
Doering, Tamara L, Hole, Camaron R, Khader, Shabaana A, Srikanta, Deepa, Williams, Matthew   +4 more
core   +2 more sources

Spontaneous regression of equine sarcoids is an exceptional event

Equine Veterinary Journal, EarlyView.
Abstract Sarcoids are benign, yet locally aggressive skin tumours that commonly affect horses and other equid species. The lesions are induced by bovine papillomavirus types 1, 2, and probably 13 in conjunction with other factors including trauma and a genetic predisposition.
Sabine Brandt
wiley   +1 more source

Analiza asocierii polimorfismelor TLR2 (-196 până la -174 ins / del) și TLR9 (1174 C / T) cu tuberculoza pulmonară în populația Moldovei

Buletinul Academiei de Ştiinţe a Moldovei: Ştiinţe Medicale, 2019
Receptorii Toll-like recunosc structurile moleculare legate de agentul patogen a micobacterii și, astfel, joacă un rol important în protecţia organismului faţă de infecţia tuberculoasă.
Alexandru Varzari, Ina Suruceanu, Ecaterina Axentii, Andrei Corloteanu, Iurie Vladei, Elena Tudor   +5 more
doaj  

Toll-Like Receptor 4, 2, and Interleukin 1 Receptor Associated Kinase4: Possible Diagnostic Biomarkers in Myelodysplastic Syndrome Patients

Advanced Biomedical Research
Background: Myelodysplastic syndrome (MDS) is a clonal hematologic disorder that requires the integration of morphologic, cytogenetic, hematologic, and clinical findings for a successful diagnosis.
Parvin Khalilian, Nahid Eskandari, Mohammad Jafar Sharifi, Mohammad Soltani, Pardis Nematollahi   +4 more
doaj   +1 more source

Systemic TLR2 tolerance enhances central nervous system remyelination

Journal of Neuroinflammation, 2019
Background Multiple sclerosis (MS) is a central nervous system (CNS) autoimmune disease characterized by both inflammatory demyelination and impaired remyelination.
Nicholas J. Wasko, Meghan Horne Kulak, Debayon Paul, Alexandra M. Nicaise, Stephen T. Yeung, Frank C. Nichols, Kamal M. Khanna, Stephen Crocker, Joel S. Pachter, Robert B. Clark   +9 more
doaj   +1 more source

Toll-like receptor stimulation induces higher TNF-alpha secretion in peripheral blood mononuclear cells from patients with hyper IgE syndrome [PDF]

, 2008
Hyper IgE syndromes (HIES) are primary immunodeficiency disorders of unknown pathogenesis. Patients are typically affected with `cold' abscesses of the skin, recurrent cyst-forming pneumonia, chronic mucocutaneous candidiasis and other less frequent ...
Alessandro Plebani, Anna Breborowicz, Bodo Grimbacher, Cristina Pietrogrande, Cristina Woellner, Doerte Thiel, Ellen Renner, Horwood NJ, Jiri Litzman, Jose L. Franco, Mehdi Yeganeh, Nima Rezaei, Nuria Matamoros, Ozden Sanal, Philipp Henneke, Sara S. Kilic, Simon Rothenfusser, Stephan Ehl, Teresa Espanol, Thomas R. Hawn   +19 more
core   +1 more source

Immunomodulatory Effect of Tilapia (Oreochromis niloticus) Scale Gelatin Peptides in RAW264.7 Macrophages and Caenorhabditis elegans

Food Safety and Health, EarlyView.
ABSTRACT Currently, small‐molecular‐weight collagen peptides are a research hotspot in functional factor development due to their high bioavailability and diverse bioactivities. In this study, gelatin was extracted from tilapia (Oreochromis niloticus) scales by hot water extraction, followed by pepsin hydrolysis and ultrafiltration to obtain the < 3 ...
Ya‐ru Liu, Xu Guo, Shu‐tao Sun, Rui‐rui Zhang, Chao Liu, Ning‐yang Li   +5 more
wiley   +1 more source

Antibiotic Remodeling of the Gut Microbiota Impairs Host Resistance to Secondary Infection

iMetaMed, EarlyView.
Gut microbial dynamics induced by four antibiotics, revealed distinct taxonomic and functional shifts. Vancomycin‐perturbed bacteriomes were proven to promote pathogen resistance to antibiotic treatment. Metronidazole‐treated mice showed pronounced Salmonella translocation to hepatic tissue, and altered Enterococcus avium populations modulated host ...
Miaoyu Li, Ying Chen, Xi Chen, Weili Lu, Jie Liao, Jiaqi Wang, Qiwei Liu, Yanzi Chang, Zeping Xu, Yanye Tu, Yang Zhou, Jing Xue, Binbin Wang, Kang Chen, Keyun Cheng, Chunlai Zeng, Hong Li, Qing Shen   +17 more
wiley   +1 more source

The minor house dust mite allergen Der p 13 is a fatty acid binding protein and an activator of a TLR2-mediated innate immune response [PDF]

, 2016
Background: The house dust mite (HDM) allergen Der p 13 could be a lipid-binding protein able to activate key innate signaling pathways in the initiation of the allergic response.
Banerjee, Batard, Bergenhenegouwen, Bublin, Calderón, Chan, Chiou, Eriksson, Eriksson, Gillilan, Gras, Guillot, Herre, Hunter, Jacquet, Jacquet, Jacquet, Jenkins, Jeong, Jimenez, Kennedy, Kennedy, Kidon, Kitajima, Lambrecht, Li, Liang, Liu, Mei, Mueller, Mueller, Osterlund, Puerta, Pulsawat, Ryu, Soh, Storch, Taylor, Thomas, Tovey, Trompette, Tully, Wiegand, Young, Zähringer   +44 more
core   +1 more source

Insulin Resistance: An Update on Biochemical and Pathophysiological Mechanisms and Impact on Various Diseases

iNew Medicine, EarlyView.
ABSTRACT Insulin resistance is the biological phenomenon in which the human body's normal response to the metabolic hormone insulin is compromised. Insulin is a regulator of most of the essential metabolic steps in the body that control energy homoeostasis, so dysregulation leads to multiple diverse human diseases including, most prominently, Type 2 ...
Peter J. Little, Stefan Offermanns, Haaglim Cho, Zhiping Liu, Pinglian Yang, Qiaozhu Su, Henry Wade, Wah Yang, Danielle Kamato, Neale Cohen, Alex Bobik, Iqra Ilyas, Suowen Xu   +12 more
wiley   +1 more source