Results 91 to 100 of about 19,241 (251)

ANALYSIS OF CYTOARCHITECTONICS OF TLR2⁺ AND TLR4⁺ LYMPHOCYTES AND TRANSCRIPTIONAL ACTIVITY OF THE GENES Gp2, Spi-B, Nf-kB1, с-REL, TNFα AND TNFr IN GALT OF RATS IN EXPERIMENTAL DIABETES MELLITUS AND AFTER PENTOXIFYLLINE ADMINISTRATION

Медицинская иммунология, 2019
Summary.Changes in the state of gut-associated lymphoid tissue (GALT) and the composition of the intestinal microbiome, both in experimental STZ-induced diabetes and in development of type 1 diabetes in humans as well as chronic inflammation due to ...
A. S. Degen, G. D. Koval, I. E. Sukhomlinova, O. V. Morozova, A. M. Kamyshnyi   +4 more
doaj   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

DETECTION OF SINGLE NUCLEOTIDE POLYMORPHISM USING TARMS-PCR IN TLR2 GENE IN LOCAL CATTLE OF JAMMU [PDF]

Exploratory Animal and Medical Research
The local cattle of Jammu is one of the unique cattle which belongs to hilly areas of Jammu. A major group of Pattern recognition receptors (PRRs) are the Toll like receptors (TLRs) which play a very important role in immunity of the animal.
Komal Deep Kour, Dibyendu Chakraborty, Nishant Kumar, Biswajit Brahma, Vidushi Sharma, Aakriti Sudan, Soshthi Talwar   +6 more
doaj   +1 more source

Bacterial induced TLR2/6 activation.

, 2014
TLR2/6 expressing HEK transfectants were co-incubated with different strains of bifidobacteria or lactobacilli. (A) Dose response experiment indicating the effects of the different supplements (FBS = fetal bovine serum, HS = human serum, plasma = human ...
Johan Garssen (278720), Aletta D. Kraneveld (278724), Arjan P. Vos (525014), Nienke Kettelarij (525013), Jeroen van Bergenhenegouwen (525011), Lieke Rutten (525012)   +5 more
core   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

TLR2 variants and Helicobacter pylori: revisiting a controversial link

Upsala Journal of Medical Sciences
Objective: Although polymorphisms in the Toll-like receptor 2 (TLR2) gene have been proposed as host genetic factors influencing susceptibility to Helicobacter pylori infection, existing data remain inconclusive.
Duygu Kirkik, Sevgi Demircioglu, Sevgi Kalkanli Taş   +2 more
doaj   +1 more source

Dysregulation of TLR2 Serves as a Prognostic Biomarker in Breast Cancer and Predicts Resistance to Endocrine Therapy in the Luminal B Subtype

Frontiers in Oncology, 2020
Background: Breast cancer (BCa) is a serious global health burden among females, and the development of resistance represents an important challenge to BCa treatment. Here, we examined the expression of toll-like receptor 2 (TLR2) in BCa patients and the
Yunmei Wang, Yunmei Wang, Shuguang Liu, Yanjun Zhang, Jin Yang   +4 more
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

TLR2-induced cytokine responses may characterize HIV-infected patients experiencing mycobacterial immune restoration disease

, 2011
Objectives: Most HIV patients who experience Mycobacterium tuberculosis-associated immune restoration disease (TB IRD) display elevated interferon-gamma (IFN?) responses against mycobacterial antigens, but these can occur without an IRD.
M. French (17249053), Patricia Price (23286325), D. Tan (11532751), A. Kamarulzaman (23338174), S. Ponnampalavanar (23547520), Y. Yong (23381986), S. Omar (6823952), A. Lim (9463490)   +7 more
core  

Comparisons of DNA methylation levels over the TLR2 promoter region and TLR2 protein expressions.

, 2020
(A)DNA methylation levels over CpG site #1, #2, #3, #8, #9, #13, #19, #22, #25 and #28 of the TLR2 promoter region were increased (p = .006, TLR2 promoter region was decreased (p = .027).
Chang-Chun Hsiao (381914), Chia-Cheng Tseng (598324), Huang-Chih Chang (598326), Meng-Chih Lin (162902), Yung-Che Chen (381913), Kuo-Tung Huang (598325), Yong-Yong Lin (4030910), Jen-Chieh Chang (381921), Chien-Hung Chin (4030907), Mao-Chang Su (33430), Ting-Ya Wang (381920), Yi-Xin Zheng (4030904)   +11 more
core   +1 more source