Results 71 to 80 of about 103,839 (247)

Contribution of TLR2 pathway in the pathogenesis of vulvovaginal candidiasis [PDF]

Pathogens and Disease, 2017
Candida albicans is the prevalent etiological agent in acute vulvovaginal infection and the most severe chronic condition known as recurrent vulvovaginal candidiasis (VVC). A critical role of local innate immunity in defense and pathogenesis of vaginal infection by Candida is proposed.
Miró, María Soledad, Rodriguez, Emilse, Vigezzi, Cecilia, Icely, Paula Alejandra, García, Luciana Noemí, Peinetti, Nahuel, Maldonado, Cristina Alicia, Riera, Fernando Oscar, Caeiro, Juan Pablo, Sotomayor, Claudia Elena   +9 more
openaire   +6 more sources

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source

IgG Glycosylation‐Dependent CLEC7A Signaling Drives Podocyte Dysfunction in Lupus Nephritis

Arthritis &Rheumatology, EarlyView.
Objective Lupus nephritis (LN) is a severe complication of systemic lupus erythematosus (SLE) that can lead to end‐stage kidney disease and increased mortality. IgG from patients with LN displays abnormal glycosylation, contributing to podocyte injury.
Rohit Upadhyay, Alexia Orellana, George C. Tsokos, Rhea Bhargava   +3 more
wiley   +1 more source

Targeting Amastigote and Trypomastigote Phases: Multi‐Epitope Vaccine Strategy Against Trypanosoma cruzi

Biotechnology and Applied Biochemistry, EarlyView.
ABSTRACT Effective vaccines against Trypanosoma cruzi, the causative agent of Chagas disease, are urgently needed. Here, we report the design and in silico validation of a novel multiepitope vaccine construct targeting the key surface proteins ASP‐2 and gp82. Using a comprehensive immunoinformatics pipeline, we identified and selected 38 potent T‐cell (
Maria Karolaynne da Silva, Caio Patrício de Souza Sena, Davi Serradella Vieira, Magdi E. A. Zaki, Leow Chiuan Yee, Shahina Akter, Umberto Laino Fulco, Jonas Ivan Nobre Oliveira, João Firmino Rodrigues‐Neto   +8 more
wiley   +1 more source

CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN

Медицинская иммунология, 2019
At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya, L. S. Namazova-Baranova, G. V. Poriadin, V. V. Grechenko, V. A. Gankovsky, A. A. Alekseeva, Zh. M. Salmashi, A. N. Kazimirsky, B. G. Bragvadze, O. A. Svitich   +9 more
doaj   +1 more source

Monitoring pharmacodynamic and molecular drug targets in liquid biopsy: Exploratory study in liver cancer with modelling of EGFR Receptor engagement

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Liquid biopsy is minimally invasive (compared with tissue biopsy) and has previously been used to generate systems data regarding drug elimination via hepatic enzymes and transporters. This study extends quantitative assessment of systems parameters in liquid biopsy to pharmacodynamic (PD) and disease markers relevant to cancer development
Zubida M. Al‐Majdoub, Armin Sepp, Amin Rostami‐Hodjegan, Brahim Achour   +3 more
wiley   +1 more source

TLR2 variants and Helicobacter pylori: revisiting a controversial link

Upsala Journal of Medical Sciences
Objective: Although polymorphisms in the Toll-like receptor 2 (TLR2) gene have been proposed as host genetic factors influencing susceptibility to Helicobacter pylori infection, existing data remain inconclusive.
Duygu Kirkik, Sevgi Demircioglu, Sevgi Kalkanli Taş   +2 more
doaj   +1 more source

ANALYSIS OF CYTOARCHITECTONICS OF TLR2⁺ AND TLR4⁺ LYMPHOCYTES AND TRANSCRIPTIONAL ACTIVITY OF THE GENES Gp2, Spi-B, Nf-kB1, с-REL, TNFα AND TNFr IN GALT OF RATS IN EXPERIMENTAL DIABETES MELLITUS AND AFTER PENTOXIFYLLINE ADMINISTRATION

Медицинская иммунология, 2019
Summary.Changes in the state of gut-associated lymphoid tissue (GALT) and the composition of the intestinal microbiome, both in experimental STZ-induced diabetes and in development of type 1 diabetes in humans as well as chronic inflammation due to ...
A. S. Degen, G. D. Koval, I. E. Sukhomlinova, O. V. Morozova, A. M. Kamyshnyi   +4 more
doaj   +1 more source

Targeting neutrophil extracellular traps in metabolic and immune niche: Nanomaterials for diabetes tissue regeneration

BMEMat, EarlyView.
The effects of NETs on regeneration of various diabetic tissues, and strategies targeting NETs for diabetes tissue regeneration. In the diabetic environment, NETs undergo complex metabolic and immune reprogramming, leading to dynamic changes in antibacterial and proinflammatory functions, and affecting regeneration of multiple systemic tissues.
Xinyi Jiang, Muxin Yue, Kai Mao, Boon Chin Heng, Noor Azlin Yahya, Yunsong Liu, Zheng Li   +6 more
wiley   +1 more source

DETECTION OF SINGLE NUCLEOTIDE POLYMORPHISM USING TARMS-PCR IN TLR2 GENE IN LOCAL CATTLE OF JAMMU [PDF]

Exploratory Animal and Medical Research
The local cattle of Jammu is one of the unique cattle which belongs to hilly areas of Jammu. A major group of Pattern recognition receptors (PRRs) are the Toll like receptors (TLRs) which play a very important role in immunity of the animal.
Komal Deep Kour, Dibyendu Chakraborty, Nishant Kumar, Biswajit Brahma, Vidushi Sharma, Aakriti Sudan, Soshthi Talwar   +6 more
doaj   +1 more source