Results 81 to 90 of about 19,241 (251)

The Role of TLR2, TLR4, and TLR9 in the Pathogenesis of Atherosclerosis [PDF]

International Journal of Inflammation, 2016
Toll-like receptors (TLRs) are key players in the pathogenesis of inflammatory conditions including coronary arterial disease (CAD). They are expressed by a variety of immune cells where they recognize pathogen-associated molecular patterns (PAMPs). TLRs recruit adaptor molecules, including myeloid differentiation primary response protein (MYD88) and ...
Mohsin H. K. Roshan, Amos Tambo, Nikolai P. Pace   +2 more
openaire   +4 more sources

A CD14‐Targeting In Situ Hydrogel Directs Macrophage Reprogramming to Minimize Scar Formation

Advanced Science, EarlyView.
A CD14‐targeting in situ hydrogel formed from a microbial polysaccharide rapidly remodels the immune microenvironment by reprogramming macrophage polarization, suppressing excessive inflammation, and coordinating tissue regeneration. This multifunctional hydrogel promotes scar‐reduced wound repair through enhanced angiogenesis, collagen remodeling, and
Rui Fang, Simeng Chen, Qiaozhen Liu, Wenwen Ni, Xi Xu, Jianfa Zhang   +5 more
wiley   +1 more source

Biophysical Characterization and Proteomic Analysis of Small Extracellular Vesicles Derived From Different Neural Cell Lines

Advanced NanoBiomed Research, EarlyView.
This study systematically compares small extracellular vesicles (sEVs) derived from four neural cell lines, revealing how cellular origin shapes vesicle biophysical properties and proteomic cargo. Distinct, lineage‐specific signatures linked to neuronal, astrocytic, and microglial functions are identified, highlighting the importance of cell source ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey E. Collins‐Praino, Andrew Care, Yuling Wang   +4 more
wiley   +1 more source

Site directed mutagenesis validates TLR2 residues involved in TLR2-VCL interaction.

, 2023
(A) NF-κB reporter-HEK293 cells were transfected with native TLR2 (W684/F719), or each of the TLR2 mutants W684A, F719A, or W684A/F719A together with TLR1 and MyD88, and then cells were stimulated with PAM (100ng/mL) for 4 h.
Jeba Gnanasekaran (15195368), Luba Eli-Berchoer (422858), Gabriel Nussbaum (269899), Fabian Glaser (9878), Karthikeyan Pandi (15195362), Sarah Angabo (15195365), Hasnaa Makkawi (15195371)   +6 more
core   +1 more source

Rewriting Tumor Immunity With Bacterial Membrane Vesicles: A Versatile and Potent Therapeutic Strategy

Advanced NanoBiomed Research, EarlyView.
Bacterial membrane vesicles (BMVs) emerge as promising platforms for cancer immunotherapy owing to their intrinsic adjuvant properties and tunable cargo delivery capabilities. Their ability to modulate the tumor microenvironment, enhance antitumor immune responses, and support personalized therapeutic strategies highlights their growing potential as ...
Md Sifat Rahi, Md Mijanur Rahman, Asma Talukder, Urooj Yousaf Virk, Jennifer C. Wilson, Nigel McMillan, Ming Q. Wei   +6 more
wiley   +1 more source

Human Cytomegalovirus miR-UL112-3p Targets TLR2 and Modulates the TLR2/IRAK1/NFκB Signaling Pathway.

, 2015
Human Cytomegalovirus (HCMV) encodes multiple microRNAs (miRNAs) whose functions are just beginning to be uncovered. Using in silico approaches, we identified the Toll-Like Receptor (TLR) innate immunity pathway as a possible target of HCMV miRNAs ...
Shannon McWeeney (39058), Shannon McWeeney, Chantel Pelton (2213323), Igor Landais (2213320), Daniel Streblow (2213317), Jay A. Nelson (190058), Chantel Pelton, Victor DeFilippis, Igor Landais, Daniel Streblow, Victor DeFilippis (200525), Jay A Nelson   +11 more
core   +1 more source

Ursolic Acid Alleviates Orchitis via Modulating Ferroptosis in Peritubular Myoid Cells of Testis

Animal Research and One Health, EarlyView.
Ursolic acid modulates key ferroptosis‐related pathways in the peritubular myoid cells of the testis in forest musk deer. ABSTRACT Chronic stress adversely affects reproductive health, increasing susceptibility to pathologies such as orchitis. Additionally, the maintenance of iron homeostasis is essential for preserving the function of the testicles ...
Yang Wang, Tianqi Jin, Zexin Chen, Ye Gong, Qimin Liu, Zifang Wu, Heran Cao, Yan Li, Yuyan Liu, Tianhao Yang, Zhihong Jiang, Wuzi Dong   +11 more
wiley   +1 more source

CHANGES OF INNATE IMMUNITY INDEXES IN SEVERE ASTHMA IN CHILDREN

Медицинская иммунология, 2019
At the present time, the role of innate immunity in pathogenesis of bronchial asthma (BA) is actively studied, in particular, significance of TLRs and cytokines. The study included 42 patients with severe bronchial asthma (from 3 to 12 years old), and 67
L. V. Gankovskaya, L. S. Namazova-Baranova, G. V. Poriadin, V. V. Grechenko, V. A. Gankovsky, A. A. Alekseeva, Zh. M. Salmashi, A. N. Kazimirsky, B. G. Bragvadze, O. A. Svitich   +9 more
doaj   +1 more source

TLR2 expression on TLR1-TLR2 transfected Jurkat JLTRg-R5 T cells.

, 2013
(A) TLR2 protein expression on JLTRg-R5 cells before (JLTRg-R5) and after transfection with empty vector (JLTRg-R5-empty) or with vector encoding TLR2/1 (JLTRg-R5-TLR1-TLR2) was determined by flow cytometry. (B) Expression of TLR2 mRNA in JLTRg-R5 before
Ahmad F. Karim (489461), David J. McDonald (489462), Myriam E. Rodriguez (489458), Candace M. Loyd (489459), Roxana E. Rojas (489463), Xuedong Ding (489460), David H. Canaday (366624)   +6 more
core   +1 more source

Modulation of Animal Gut Health by Milk Oligosaccharide

Animal Research and One Health, EarlyView.
This review summarizes the composition and structural characteristics of MOs across different mammalian species, and elucidates their roles and mechanisms in maintaining intestinal homeostasis by regulating gut microbiome and enhancing intestinal chemical, physical and immune barriers.
Ningtao Chen, Nana Jing, Shiyu Tao, Mingyue Fei, Wentao Lv, Hua Yang, Yingping Xiao, Haiqin Wu   +7 more
wiley   +1 more source