Results 101 to 110 of about 103,839 (247)

Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice

陆军军医大学学报
Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs.
CHENG Hao, YANG Yun, SUN Hongwu
doaj   +1 more source

IL‐33 Drives Inflammatory Changes and Extracellular Trap Formation in Eosinophils Involving Oxidised LDL and Complement Pathways

Allergy, EarlyView.
IL‐33 induces inflammatory gene signatures in eosinophils, characterised by the upregulation of cell surface markers, inflammatory mediators and regulatory factors, all of which were also observed in nasal polyp‐derived eosinophils. Ox‐LDL and complement fragments (C3a and C5a) promote eosinophil adhesion and survival.
Emiko Matsuyama, Jun Miyata, Takao Mochimaru, Ryuta Onozato, Yo Otsu, Hisashi Sasaki, Keeya Sunata, Shinichi Okuzumi, Katsunori Masaki, Hiroki Kabata, Keinosuke Hizuka, Yoshinori Hasegawa, Ryo Konno, Yusuke Kawashima, Makoto Arita, Shigeharu Ueki, Koichi Fukunaga   +16 more
wiley   +1 more source

Prevalence of innate immunity gene variants rs5743708, rs3853839, and rs8177374 in patients hospitalized in 2021 with a diagnosis of COVID-19

Сибирский научный медицинский журнал
The host genotype is one of the key factors determining the likelihood of infection, severity and outcome of the novel coronavirus infection in humans.
S. V. Mikhailova, M. Yu. Moskvina, D. E. Ivanoshchuk, O. P. Khripko, P. S. Orlov, D. V. Denisova, P. A. Shesternya, M. I. Voevoda   +7 more
doaj   +1 more source

Lupus Panniculitis Immunoprofiling Reveals a Cytotoxic, Type 1‐Skewed T‐Cell Response With Signs of Metabolic Alteration

Allergy, EarlyView.
Imaging mass cytometry shows lupus panniculitis lesions are dominated by cytotoxic and skin‐homing T cells with abundant macrophages and B‐cell aggregates. Spatial neighborhood analysis reveals organized leukocyte architecture, including B‐cell proximity to naïve T cells and M1 macrophages to cytotoxic T cells.
Milad Ameri, Reihane Ziadlou, Stephan Traidl, Milena Sokolowska, Emmanuel Contassot, Nick Li, Maija Kiuru, Isabel Kolm, Werner Kempf, Emanual Maverakis, Cezmi Akdis, Marie‐Charlotte Brüggen   +11 more
wiley   +1 more source

Keratinocyte Priming by Staphylococcus aureus Reduces HSV‐1 Susceptibility

Allergy, EarlyView.
ADEH+ patients have a reduced microbial diversity with increased S. aureus and S. epidermidis colonization compared to ADEH− and healthy controls. Heat‐killed S. aureus reduced HSV‐1 susceptibility and release of infectious progeny virus in a keratinocyte in vitro model. Heat‐killed S.
Phila Cara Baumann, Rebecca Pospich, Katinka Döhner, Ilona Klug, Julio Cesar Villalvazo Guerrero, Jan Hartmann, Inken Harder, Wolfgang Lieb, Barbara Kind, Andreas Kleinheinz, Susanne Abraham, Matthias Augustin, Elke Weisshaar, Jochen Schmitt, Stephan Weidinger, Beate Sodeik, Thomas Werfel, Lennart M. Roesner, Stephan Traidl, The TREATgermany Study Group   +19 more
wiley   +1 more source

Toll-like receptor 2-mediated ERK activation significantly upregulates interleukin-6 expression in M2-polarized macrophages

Türk Biyokimya Dergisi
M2-polarized macrophages and interleukin (IL)-6 significantly alter the tumor microenvironment and promote the malignant behaviors of tumor cells. This study aimed to establish M2-type macrophages from THP-1 cells, which are human leukemia monocytes, and
Jo Wol Soon, Kim Sung Dae, Jeong Soo Kyung, Oh Su Jung, Baik Ji Sue, Seo Ji An, Baek Jeong-Hwa, Lee Chang Geun, Kang Young-Rok, Jeong Min Ho, Park Moon-Taek   +10 more
doaj   +1 more source

Basophils in Immunity: Activation Pathways, Roles in Allergy and AllergoOncology and Application of the Basophil Activation Test

Allergy, EarlyView.
ABSTRACT Basophils, the least abundant leukocytes, are increasingly recognised as potent immunomodulators. Upon activation, they rapidly release preformed granule‐associated mediators including histamine and lipid mediators such as LTC4, while cytokine production occurs over a longer timescale, contributing to downstream immune responses.
Jitesh Chauhan, Sofia Vlasova, Alicia Chenoweth, Debra H. Josephs, Heather J. Bax, Sophia N. Karagiannis   +5 more
wiley   +1 more source

From haemostasis to immunity: The expanding frontiers of platelet biology

British Journal of Haematology, EarlyView.
Platelets are versatile cells whose functions extend far beyond haemostasis and thrombosis, actively regulating innate and adaptive immunity, angiogenesis, lymphangiogenesis, liver regeneration, atherosclerosis and tumour metastasis. This demonstrates their central role in various physiological processes and multiple life‐threatening diseases ...
Xun Grace Wu, Nicole Tomei, Heyu Ni
wiley   +1 more source

Gut microbiota as a novel therapeutic target for eating disorders and obesity

British Journal of Pharmacology, EarlyView.
The graphical abstract highlights the bidirectional interaction between the gut microbiota and central homeostatic and hedonic mechanisms regulating food intake, which contributes to overweight and obesity. It also illustrates emerging microbiota‐based biomarkers and therapeutic strategies (including prebiotics, probiotics, postbiotics, synbiotics and ...
Solveiga Samulėnaitė, Victor Mathis, Emmanuel Darcq, Aurelijus Burokas, Elena Martín‐García, Rafael Maldonado   +5 more
wiley   +1 more source

Monocytes Derived From Human Pluripotent Stem Cells Engineered for Detection of Pyrogens

Cell Proliferation, EarlyView.
In summary, we have developed a monocyte‐based reporter system using hESC‐Mono for interrogating the NF‐κB signalling axis, a central pathway governing pyrogenic responses. Our platform enables rapid and dose‐dependent detection of both endotoxins (LPS) and non‐endotoxins (LTA and Zymosan).
Jingjing Liu, Bingyu Cai, Tingting Gao, Wumei Wei, Liu Wang, Qi Zhou, Wei Li, Jie Hao, Jun Wu   +8 more
wiley   +1 more source