Results 61 to 70 of about 19,241 (251)

Novel mutations in the toll like receptor genes cause hyporesponsiveness to Mycobacterium avium subsp. paratuberculosis infection [PDF]

, 2008
Toll like receptors play a central role in the recognition of pathogen associated molecular patterns (PAMPs). Mutations in TLR1, TLR2 and TLR4 genes may change the PAMP reorganization ability which causes altered responsiveness to the bacterial pathogens.
Rostislav Skrabana, Michal Novak, Mangesh Bhide, Ivan Mikula Jr., Rastislav Mucha, Lucia Kisova, Ivan Mikula Sr.   +6 more
core  

A Pancreatitis‐Inspired Trypsinogen Nanoplatform Reprograms Tumor‐Associated Macrophages via NF‐κB for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
Trypsinogen‐loaded nanoparticles reprogram TAMs via NF‐κB/NLRP3, driving M2→M1 conversion and potent phagocytosis to unleash antitumor immunity. ABSTRACT Although reprogramming tumor‐associated macrophages (TAMs) represents a promising therapeutic strategy, approaches that are both precise and safe remain scarce.
Lei Cao, Yu He, Wenhao Li, Bo Gong, Han Lin, Jianlin Shi, Yuan Yong, Wencheng Wu   +7 more
wiley   +1 more source

The role of Toll-like receptor 2 in inflammation and fibrosis during progressive renal injury. [PDF]

PLoS ONE, 2009
Tissue fibrosis and chronic inflammation are common causes of progressive organ damage, including progressive renal disease, leading to loss of physiological functions.
Jaklien C Leemans, Loes M Butter, Wilco P C Pulskens, Gwendoline J D Teske, Nike Claessen, Tom van der Poll, Sandrine Florquin   +6 more
doaj   +1 more source

Responsiveness of human TLR2 (N657E), TLR2 (L663E) and TLR2 (N688A) to TLR2/2, TLR2/1 and TLR2/6 agonists.

, 2013
HEK293T cells in 24-well plates were transfected with human TLR2 (N657E), TLR2 (L663E) or TLR2 (N688A), and TK-RL and pBIIx-luc. At 24 h post-transfection, the cells were stimulated with the indicated concentrations of LTA (A), Pam3CSK4 (B) and FSL (C ...
Yan Ding (39795), Wenyue Xu (405712), Lingyun Zou (333969), Yuan Qiu (405709), Xiaolan Fu (195090), Zhangping Tan (405710), Taiping Liu (405711)   +6 more
core   +1 more source

Activation of Ca2+-Dependent Signaling by TLR2 [PDF]

The Journal of Immunology, 2006
Abstract Upon contact with airway epithelial cells, bacterial products activate Ca2+ fluxes that are required for induction of NF-κB-dependent gene expression. TLR2 is apically displayed on airway cells, making it a likely transducer linking bacterial stimuli and kinases that affect Ca2+ release. Using biochemical and genetic approaches,
Jarin, Chun, Alice, Prince
openaire   +2 more sources

Biomimetic Nanoplatform for Dual Target Nano‐Metabolic Therapy in Diabetes‐Associated Biofilm Infections

Advanced Science, EarlyView.
A biomimetic GOx/Arg‐loaded nanoplatform produces nitric oxide through an in situ catalytic cascade reaction, enabling dual‐target metabolic regulation in diabetes‐associated biofilm infections. Bacterial metabolism is disrupted, and macrophage immunometabolism is reprogrammed, resulting in biofilm eradication, immune restoration, and enhanced ...
Mingzhang Li, Yonglong Li, Jiren Yan, Changming Wang, Jinlong Yu, Feng Jiang, Boyong Wang, Yi Yang, Deyi Ding, Jin Tang, Pei Han, Botao Song, Geyong Guo, Hao Shen   +13 more
wiley   +1 more source

TLR2-responsive JMJD3 regulates mycobacteria-induced FM formation and immune responses.

, 2016
(A and B) Mouse peritoneal macrophages were infected with the indicated bacteria (H37Ra: M. tuberculosis H37Ra; BCG: M. bovis BCG; MS: M. smegmatis) for 6 h. Immunoblot analysis for H3K27me3, EZH2 and JMJD3 (A) and quantitative real-time RT-PCR for Jmjd3
Praveen Prakhar (2985372), Tanushree Mukherjee (2985366), Sahana Holla (2985369), Pankti Parikh (516986), Vikas Singh (2985357), R. S. Rajmani (2985354), Kasturi Mahadik (2985360), Anupama Karnam (2985363), Subbaraya G. Ramachandra (2985375), Amit Singh (130923), Kithiganahalli Narayanaswamy Balaji (118414)   +10 more
core   +1 more source

Crosstalk between NOD2 and TLR2 suppresses the development of TLR2-mediated experimental colitis

Journal of Clinical Biochemistry and Nutrition
Nucleotide-binding oligomerization domain 2 (NOD2) is an intracellular sensor for muramyl dipeptide (MDP), a degradation product of bacterial cell wall peptidoglycan (PGN). PGN stimulates cell-surface Toll-like receptor 2 (TLR2) independently of NOD2, indicating the presence of crosstalk between extracellular TLR2 and intracellular NOD2 upon exposure ...
Okai, Natsuki, Masuta, Yasuhiro, Otsuka, Yasuo, Hara, Akane, Masaki, Sho, Kamata, Ken, Minaga, Kosuke, Honjo, Hajime, Kudo, Masatoshi, Watanabe, Tomohiro   +9 more
openaire   +2 more sources

Membrane‐Active Peptide Protects Against Inflammation by Targeting NLRP3 Activation at the Trans‐Golgi Network

Advanced Science, EarlyView.
The membrane‐active peptide Pep19‐2.5 reduces harmful inflammation by blocking activation of the NLRP3 inflammasome at trans‐Golgi network membranes. By targeting key membrane interactions, Pep19‐2.5 suppresses inflammatory IL‐1β production and alleviates allergic airway inflammation in mice, leading to reduced immune cell infiltration and improved ...
Jonas Engelhardt, Nico Kirsch, Aileen Kerfin, Lars P. Lunding, Dominic Ferber, Hannes Buthmann, Ilka Schreier, Carlotta Bosio, Ann‐Kathrin Dobbelstein, Anna Klawonn, Rebecca C. Coll, Lena Bauernhofer, Sandro Keller, Matthias Geyer, Michael Wegmann, Andra B. Schromm, Günther Weindl   +16 more
wiley   +1 more source

A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis

Frontiers in Bioscience-Landmark
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture.
Baoxin Yan, Xiaoxian Yu, Xianzhen Cai, Xiaojun Huang, Bin Xie, Danchun Lian, Jinhao Chen, Weiwen Li, Ying Lin, Junjun Ye, Jilin Li   +10 more
doaj   +1 more source