Results 51 to 60 of about 152,328 (305)

The TLR2/6 ligand PAM2CSK4 is a Th2 polarizing adjuvant in Leishmania major and Brugia malayi murine vaccine models. [PDF]

, 2016
Toll-like receptors (TLRs) play an important role in the innate and adaptive immune responses to pathogens, and are the target of new vaccine adjuvants.
Bates, PA, Guimarães, A, Halliday, A, Taylor, MJ, Turner, JD   +4 more
core   +7 more sources

TLR2 as a Therapeutic Target in Bacterial Infection

Trends in Molecular Medicine, 2020
Toll-like receptor (TLR) 2 recognizes and responds to threats early in bacterial infections and can influence the downstream immune response to the host's benefit or detriment. Therapeutic modulation of TLR2 signaling represents an underutilized opportunity to moderate the immune response to infection to promote an improved outcome for the host.
Morgan E, Simpson, William A, Petri
openaire   +3 more sources

Activation of Ca2+-Dependent Signaling by TLR2 [PDF]

The Journal of Immunology, 2006
Abstract Upon contact with airway epithelial cells, bacterial products activate Ca2+ fluxes that are required for induction of NF-κB-dependent gene expression. TLR2 is apically displayed on airway cells, making it a likely transducer linking bacterial stimuli and kinases that affect Ca2+ release. Using biochemical and genetic approaches,
Jarin, Chun, Alice, Prince
openaire   +2 more sources

A Review: The Significance of Toll-Like Receptors 2 and 4, and NF-κB Signaling in Endothelial Cells during Atherosclerosis

Frontiers in Bioscience-Landmark
Atherosclerosis (AS) is a chronic inflammatory vascular disease that begins with endothelial activation followed by a series of inflammatory responses, plaque formation, and finally rupture.
Baoxin Yan, Xiaoxian Yu, Xianzhen Cai, Xiaojun Huang, Bin Xie, Danchun Lian, Jinhao Chen, Weiwen Li, Ying Lin, Junjun Ye, Jilin Li   +10 more
doaj   +1 more source

TLR2: A Crossroads between Infections and Autoimmunity? [PDF]

International Journal of Immunopathology and Pharmacology, 2011
Environment has both pathogenic and protective roles in the determination of autoimmune disease development, possibly through infectious agents. TLR2 has the capability to recognize the widest range of PAMPs, and it is important for the recognition of mycobacteria and gram-positive bacteria. Here we review recent information showing that TLR2 ligands,
Borrello, Silvia, Nicolò, C, Delogu, Giovanni, Pandolfi, Franco, Ria, Francesco   +4 more
openaire   +3 more sources

Ketogenic Diet as an Epigenetic Therapy in SETD1B‐Related Epilepsy

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Histone lysine methyltransferases such as SETD1B regulate chromatin structure and gene transcription. Ketone bodies, including butyrate, act as histone deacetylase inhibitors. We report a 4‐year‐old boy with SETD1B‐related absence epilepsy, refractory to conventional medications, who achieved sustained > 90% seizure reduction on the Modified ...
Erica Tsang, Brian S. Gloss, Jessica P. Hayes, Andrew J. A. Holland, Manoj P. Menezes, Joceline A. Branson, Shekeeb S. Mohammad, Jingya J. Yan, Shrujna Patel, Velda X. Han, Russell C. Dale   +10 more
wiley   +1 more source

Argon Alleviates Bone Cancer Pain by Mitigating Neuronal Ferroptosis via the TLR2-COX-2 Pathway

Frontiers in Bioscience-Landmark
Background: Bone cancer pain (BCP) related neuronal damage is associated with ferroptosis, a regulated cell death dependent on iron. The noble gas argon is known to have neuroprotective effects, reducing neuroinflammation and enhancing
Peipei Kang, Gujun Cong, Xiaowen Meng, Yang Zhang, Haiyan Sun, Lei Wang, Chao Zhang, Junyi Ma, Tong Liu, Fuhai Ji   +9 more
doaj   +1 more source

The liver X receptor pathway is highly upregulated in rheumatoid arthritis synovial macrophages and potentiates TLR-driven cytokine release [PDF]

, 2013
<p>Objectives: Macrophages are central to the inflammatory processes driving rheumatoid arthritis (RA) synovitis. The molecular pathways that are induced in synovial macrophages and thereby promote RA disease pathology remain poorly understood.</
Ananth, Antoniv, Asquith, Asquith, Baeten, Bresnihan, Darren Lee Asquith, Enevold, Feldmann, Fontaine, Gerlag, Haringman, He, Huang, Iain B McInnes, Iwahashi, J Alastair Gracie, Jagtar Singh Nijjar, Jahangier, James H Reilly, Janowski, Kauffmann, Kinne, Koch, Long, Lucy E Ballantine, Manhal Khuder Makdasy, Mariola Kurowska-Stolarska, Mulherin, Ospelt, Pamela B Wright, Radstake, Ridley, Sabina Patel, Sack, Sacre, Sattar, Shauna Kerr, Tamaki, van der Heijden, van Halm, van Sijl, Zhao   +42 more
core   +1 more source

Small Extracellular Vesicles from Neural Cells: Physiological and Pathological Roles, and Potential in Neurodegenerative Therapy

Advanced Healthcare Materials, EarlyView.
Neural cell–derived small extracellular vesicles (sEVs) are emerging as pivotal mediators in neurodegenerative diseases, exerting both pathogenic and therapeutic functions. This review synthesizes current evidence on how sEVs from distinct neural cell types regulate neurodegeneration, neuroprotection, biomarker discovery, and targeted drug delivery ...
Muhammad Waqas Salim, Wei Zhang, Lyndsey Collins‐Praino, Yuling Wang, Andrew Care   +4 more
wiley   +1 more source

Clostridium scindens promotes gallstone formation by inducing intrahepatic neutrophil extracellular traps through CXCL1 produced by colonic epithelial cells

Microbial Cell
Cholelithiasis is one of the most common diseases of the biliary system. Neutrophil extracellular traps (NETs) in the liver play an important role in accelerating the formation of gallstones. The upstream mechanism of NETs formation remains unclear.
Wenchao Yao, Yuanhang He, Zhihong Xie, Qiang Wang, Yang Chen, Jingjing Yu, Xuxu Liu, Dongbo Xue, Liyi Wang, Chenjun Hao   +9 more
doaj   +1 more source