Results 161 to 170 of about 156,491 (330)

Alternative Polyadenylation Drives Runaway Pro‐Inflammatory Macrophages in Periodontitis by Enabling Escape From miRNA Repression

Cell Proliferation, EarlyView.
APA‐Guided Therapeutic miRNA Selection for Periodontitis. ABSTRACT Periodontitis is a chronic inflammatory disease driven by a dysregulated host immune response, in which macrophage‐mediated inflammation shifts from protective to pathological. While monocyte‐derived macrophages (MDMs) are known to adopt a destructive, M1‐like pro‐inflammatory phenotype,
Jing Zhang, Yilong Zhao, Jiaru Deng, Shuyuan Qu, Yiyi Zhou, Qin Zhao, Yufeng Zhang   +6 more
wiley   +1 more source

Filtered Kombucha Tea Rings the Bell for TLR2, TLR4, MYD88, and Dectin-1 in Mice Model of Colitis

, 2020
Elaheh Mahmoudi, Mansoureh Yazdkhasti, Amin Gharanfoli   +2 more
openalex   +2 more sources

Lung organoids as a human system for Mycobacteria infection modeling and drug testing

The FEBS Journal, EarlyView.
Mycobacterial infections, including tuberculosis (TB) and infections by nontuberculous mycobacteria (NTM), are still public health issues. In 2023, TB caused 1.25 million deaths, while NTM remain a clinical challenge for patients with cystic fibrosis (CF).
Stephen Adonai Leon‐Icaza, Romain Vergé, Raoul Mazars, Laurence Berry, Céline Cougoule   +4 more
wiley   +1 more source

Targeting the microbiota‐miRNA‐protease axis: A new therapeutic avenue in melanoma

The FEBS Journal, EarlyView.
Modulation of extracellular matrix (ECM) turnover is central to melanoma progression and metastasis, driven largely by ECM proteases. This review highlights the epigenetic regulation of ECM proteases by microRNAs and their roles in melanoma growth, invasion, and immune modulation.
Elias N. Katsoulieris, Paraskevi Ioannou, Nikolaos A. Afratis   +2 more
wiley   +1 more source

Potent Inhibition of Macrophage Responses to IFN-γ by Live VirulentMycobacterium tuberculosisIs Independent of Mature Mycobacterial Lipoproteins but Dependent on TLR2 [PDF]

, 2006
Niaz Banaiee, Eleanor Kincaid, Ulrike K. Buchwald, William R. Jacobs, J. Ernst   +4 more
openalex   +1 more source

TLR2 wt Allele [PDF]

, 2020
openaire   +1 more source

Exploring Persistent Apical Periodontitis in Humans: Integrative Genetic, Histological and Microbiological Perspectives for Translational Research

International Endodontic Journal, EarlyView.
ABSTRACT Aim To evaluate the impact of polymorphisms in SOCS‐1, TNF‐α and RANKL on gene expression of RANK, RANKL, TNFRSF1, SOCS‐1, IL‐10, IL‐1β and TNF‐α, and to evaluate the histopathological, immunohistochemical and microbiological aspects of persistent apical periodontitis (PAP) after root canal treatment (RCT) in Brazilian individuals ...
Igor Bassi Ferreira Petean, Alice Corrêa Silva‐Sousa, Rafael Verardino de Camargo, Yara Terezinha Corrêa Silva‐Sousa, Fernanda Gonçalves Basso, André Pitondo‐Silva, Francisco Wanderley Garcia de Paula‐Silva, Erika Calvano Kuchler, Raquel Assed Bezerra da Silva, Lea Assed Bezerra da Silva, Jardel Francisco Mazzi‐Chaves, Fabiane Carneiro Lopes‐Olhê, Manoel Damião Sousa‐Neto   +12 more
wiley   +1 more source

Skin‐Derived Precursors‐Derived Exosomes Alleviated Acne Inflammation via TLR2 / MyD88 / NF ‐ κB Signaling Pathway: In Vitro and In Vivo Studies [PDF]

Y Li, Shiyi Li, Manlin Guo, Yangqi Zhang, Yaojia Nie, Yang Bo, Li Li   +6 more
openalex   +1 more source

Gut Microbiome Alterations by Allergen Sensitisation and Symptom Severity in Paediatric Allergic Rhinitis

Allergy, EarlyView.
Kunio Miyake, Daisuke Watanabe, Sanae Otawa, Megumi Kushima, Hideki Yui, Ryoji Shinohara, Daiju Sakurai, Zentaro Yamagata   +7 more
wiley   +1 more source

Innate Immune Activation Is a Strong Suppressor of CCL22 and Impedes Regulatory T Cell–Dendritic Cell Interaction

Immunology, EarlyView.
During homeostasis, CCL22 is secreted by dendritic cells (DC), which mediate contacts between regulatory T cells (Treg) and DC to maintain immune balance. Activation of innate immunity via microbes or pattern recognition receptor (PRR) agonists induces the secretion of several soluble factors (e.g., type I and II interferons, IL‐10), which mediate ...
Ignazio Piseddu, Jan Gärtig, Stephan Eiber, Stefan Moder, Raffael Thaler, Matthias Thaler, Juliane Gruen, Marlies Vornhülz, Kevin Bahner, Luana Messa, Benjamin Kühnemuth, Jennifer Müller, Konstantin Schnell, Antonia Beimert, Carolin Perleberg, Natascha Röhrle, Maximilian Martin Ludwig Knott, Linda Hammann, Vanessa Wittmann, Patrick Layritz, Moritz Rapp, Carole Bourquin, Julia Mayerle, Stefan Endres, David Anz   +24 more
wiley   +1 more source