Results 161 to 170 of about 133,056 (344)
PLoS ONE, 2019 Subacute and chronic infections with the intracellular protozoan parasite Toxoplasma gondii are associated with an increased risk of psychiatric diseases like schizophrenia. However, little is known about the mechanisms involved in T.
Fumiaki Ihara +4 more
doaj +1 more source
TLR2 signaling is required for the innate, but not adaptive response to LVS clpB
Frontiers in Immunology, 2014 Toll-like receptor 2 (TLR2) is the best characterized pattern-recognition receptor for the highly pathogenic intracellular bacterium, Francisella tularensis.
Lydia Marie Roberts +3 more
doaj +1 more source
Toll-Like Receptors in the Immunotherapy Era: Dual-Edged Swords of Tumor Immunity and Clinical Translation. [PDF]
MedComm (2020)This review discussed the signaling pathways of Toll‐like receptors in tumors and their antitumor or protumor regulatory effects in diverse tumors. We also paid attention to the application of Toll‐like receptors in clinical treatment and summarized the clinical trial situation in recent years.
Maihemuti N +7 more
europepmc +2 more sources
Paeoniflorin prevents TLR2/4-mediated inflammation in type 2 diabetic nephropathy.
BioScience Trends, 2017 Paeoniflorin is an effective Chinese traditional medicine with anti-inflammatory and immune-regulatory effects. The aim of this study was to investigate the underlying renoprotective mechanism of Paeoniflorin.
Tingmin Zhang +4 more
semanticscholar +1 more source
Targeting thymic stromal lymphopoietin in nasal type 2 inflammation
Eye &ENT Research, EarlyView.Abstract Epithelial cell‐derived thymic stromal lymphopoietin (TSLP) plays a crucial role in mediating type 2 immune responses, which is one of the key underlying pathophysiological mechanisms of allergic rhinitis (AR) and most presentations of chronic rhinosinusitis with nasal polyps (CRSwNP).
Xintong Li +3 more
wiley +1 more source
Targeting microglial TLR2 in glioma therapy
, 2021 Gliomas are the most frequent brain tumors and are characterized by a poor prognosis despite extensive research in recent years. Microglia constitute the main population of immune cells in the central nervous system and ensure the compliance of homeostasis under physiologic conditions but they have been found to play a pivotal role in tumor progression.
openaire +2 more sources
Protective effect of TLR2/TLR9 agonists on pulmonary Acinetobacter baumannii infection in mice
陆军军医大学学报Objective To investigate the protective effect of Toll-like receptor (TLR) 2 /TLR9 agonists, Pam2CSK4 (Pam) and CpG ODN (CpG) on mice infected with Acinetobacter baumannii (Ab) in the lungs.
CHENG Hao, YANG Yun, SUN Hongwu
doaj +1 more source
Differential roles of TLR2 and TLR4 in the host response to Gram-negative bacteria: lessons from a lipopolysaccharide-deficient mutant of Neisseria meningitidis [PDF]
, 2000 Robin R. Ingalls +2 more
openalex +1 more source
European Journal of Heart Failure, EarlyView.Abstract Aims Age‐associated clonal haematopoiesis of indeterminate potential (CHIP) has been linked to increased incidence and worse prognosis of chronic heart failure (CHF). CHIP arises from somatic mutations in haematopoietic stem and progenitor cells. Mosaic loss of Y chromosome (LOY), the most common somatic mutation in male blood cells, increases
Sebastian Cremer +15 more
wiley +1 more source
TLR2 Controls Intestinal Carcinogen Detoxication by CYP1A1
PLoS ONE, 2012 Intestinal cytochrome P450 subclass 1A1 (CYP1A1) contributes to a metabolic "shield" protecting the host from ingested carcinogens such as polycyclic aromatic hydrocarbons (PAH). The expression of CYP1 (including CYP1A2 and CYP1B1) is considered to depend solely on a heterodimeric transcription factor consisting of the arylhydrocarbon receptor (AHR ...
Alexandr Parlesak +5 more
openaire +7 more sources