Drug Development Research, Volume 87, Issue 3, May 2026.ABSTRACT Glioblastoma (GBM) remains one of the most lethal brain malignancies because of its highly immunosuppressive tumor microenvironment and the limited penetration of therapeutics across the blood‐brain barrier (BBB). Although recent studies have separately explored STING agonism, microglial reprogramming, and nanocarrier‐based drug delivery, an ...
Mohamed S. Nafie +2 more
wiley +1 more source
Borrelia burgdorferi sensu lato Employs Several Escape Mechanisms to Bypass the Human Defense System
European Journal of Immunology, Volume 56, Issue 5, May 2026.Integrated overview of host defense and immune evasion in Lyme Borreliosis. Bbsl evades immunity through tick saliva‐mediated suppression of innate defenses, TLR2/NOD2‐driven cytokine dysregulation, and interference with JAK/STAT and CIITA‐dependent antigen presentation.
Zara Karami +2 more
wiley +1 more source
Expression of Concern: Toll-Like Receptor 2 Targeted Rectification of Impaired CD8+ T Cell Functions in Experimental Leishmania donovani Infection Reinstates Host Protection. [PDF]
PLoS OnePLOS One Editors.
europepmc +1 more source
Food Frontiers, Volume 7, Issue 3, May 2026.Rosa roxburghii‐derived exosome‐like nanovesicles target the intestine, repairing barriers, regulating gut microbiota, balancing Th17/Treg, and combating oxidative stress/inflammation to alleviate colitis, a promising UC therapy. ABSTRACT Plant‐derived nanovesicles (PDVs), an innovative and bioactive form of natural products, are key mediators of ...
Yuanyuan Wang +8 more
wiley +1 more source
An underlying mechanism of bovine mastitis: PGE<sub>2</sub> regulates <i>Staphylococcus aureus</i>-induced inflammatory response through TLR2, TLR4, and NLRP3 in macrophages. [PDF]
Vet QGong Z +9 more
europepmc +1 more source
Food Science &Nutrition, Volume 14, Issue 5, May 2026.IBP35, a combination of Lactiplantibacillus plantarum IDCC 3501 and Ligilactobacillus salivarius IDCC 3551, enhanced macrophage activation in RAW 264.7 cells and improved multiple immune readouts in cyclophosphamide‐induced immunosuppressed mice, including splenocyte proliferation, NK cell activity, cytokine production, macrophage phagocytic activity ...
Han Bin Lee +4 more
wiley +1 more source
The soluble G protein of respiratory syncytial virus promotes viral dissemination via TLR2-mediated NLRP3 priming and pyroptosis. [PDF]
Npj VirusesMeineke R +5 more
europepmc +1 more source
Health Science Reports, Volume 9, Issue 5, May 2026.ABSTRACT Background Nanoparticles (NPs) are increasingly used in industry for their unique properties. However, prolonged occupational exposure to common NPs like titanium dioxide (TiO₂), zinc oxide (ZnO), silver (Ag), and silica (SiO₂) may trigger systemic inflammation and contribute to chronic obstructive pulmonary disease (COPD).
Vahid Babaei +9 more
wiley +1 more source
Impact of testosterone-based gender-affirming hormone therapy on toll-like receptor transcript levels and peripheral blood leukocyte counts in transmasculine individuals. [PDF]
Front ImmunolCihan H +10 more
europepmc +1 more source
Immunoinformatic-driven design of a multi-epitope vaccine against <i>Helicobacter</i> <i>pylori</i>. [PDF]
Biochem Biophys RepRahimi-Farsi N +6 more
europepmc +1 more source