Results 331 to 340 of about 133,056 (344)

TLR2: for or against Candida albicans?

Trends in Microbiology, 2005
In a recent issue of Trends in Microbiology, Netea and coworkers presented their opinion that toll-like receptors (TLRs) are involved in escape from the defense mechanisms of the host [1]. In their article, the authors clearly identified three major TLR-mediated escape mechanisms that are used by microbial pathogens, such as Yersinia, Mycobacterium and
Daniel Gozalbo, M. Luisa Gil, Didier Fradelizi   +2 more
openaire   +3 more sources

Rare TLR2 mutations reduce TLR2 receptor function and can increase atopy risk

Allergy, 2009
Background:  Common genetic variations in toll‐like receptor 2 (TLR2), an innate pathogen recognition receptor, may influence the development of atopic diseases. So far, very little is known about the role of rare TLR2 mutations in these diseases.Objective:  We investigated the functional properties of six rare amino acid changes in TLR2 (and one amino
Thomas Illig, N. Klopp, Stephan Spiller, Michael Kormann, E. von Mutius, Michael Kabesch, Ruth Ferstl, Christian Vogelberg, Martin Depner, Carsten J. Kirschning   +9 more
openaire   +3 more sources

Lipid-associated membrane lipopeptides of M. arginini activate NF-κB by interacting with TLR2/1, TLR2/6, and TLR2/CD14

Molecular Genetics, Microbiology and Virology, 2009
Various strains of mycoplasmas cause the activation of transcriptional factor NF-κB as a result of interactions with different combinations of Toll-like receptors (TLRs). It is well known that MALP-2 protein of M. fermentans activates NF-κB through interactions with TLR2/6, activates lipid-associated membrane lipopeptides (LAMPs) of M.
Andrei V. Gudkov, Denis Y. Logunov, A L Gintsburg, B. S. Naroditskii, I. V. Rakovskaya, M M Shmarov, D. V. Scheblyakov, O. V. Zubkova   +7 more
openaire   +2 more sources

TLR2 Promotes Glioma Immune Evasion by Downregulating MHC Class II Molecules in Microglia

Cancer immunology research, 2018
In the glioma tumor microenvironment, TLR2 activation of microglia induces downregulation of microglial MHC class II expression. Impaired MHC class II expression limits T cell–dependent antitumor immunity.
Jiawen Qian, Feifei Luo, Jiao Yang, Jun Liu, Ronghua Liu, Luman Wang, Chen Wang, Yuting Deng, Zhou Lu, Yuedi Wang, Mingfang Lu, Ji-Yang Wang, Y. Chu   +12 more
semanticscholar   +1 more source

TLR2 agonists and their structure–activity relationships

Organic & Biomolecular Chemistry, 2020
We review the structure–activity relationships and synthetic studies of TLR2 agonists – important chemical targets in immunotherapy.
Benjamin L. Lu, Geoffrey M. Williams, Margaret A. Brimble   +2 more
openaire   +2 more sources

The Noninflammatory Side of TLR2

Science Signaling, 2012
Toll-like receptor 2 promotes tumorigenesis in a mouse model of gastric cancer, but not by enhancing inflammation.
openaire   +2 more sources

TLR2 joins the interferon gang

Nature Immunology, 2009
The induction of type I interferon is a critical checkpoint in antiviral immunity. Toll-like receptor 2 can unexpectedly induce type I interferon in the subset of inflammatory monocytes during infection with vaccinia virus.
Franz Bauernfeind, Veit Hornung
openaire   +2 more sources

TLR2 Arg677Trp polymorphism in leprosy: revisited

Human Genetics, 2005
We investigated the Toll-like receptor 2 (TLR2) Arg677Trp polymorphism, associated with lepromatous leprosy in the Korean population and shown to abrogate TLR2-mediated signalling in response to mycobacterial ligands, in 286 Indian leprosy patients and 183 ethnically matched controls.
Dheeraj Malhotra, Vineet Relhan, Belum Siva Nagi Reddy, Ramesh Bamezai   +3 more
openaire   +3 more sources

Fungal Recognition by TLR2 and Dectin-1

2008
The innate immune system utilizes multiple receptors to recognize fungal pathogens, and the net inflammatory response is controlled by interactions between these receptors. Many fungi are recognized, at least in part, by Toll-like receptor 2 (TLR2) and Dectin-1.
David M. Underhill, Helen S. Goodridge
openaire   +3 more sources

β3 Integrin as a Coreceptor for TLR2

Science Signaling, 2008
Toll-like receptor 2 (TLR2) is one of a family of TLRs involved in recognition of pathogenic molecular motifs. TLR2 signaling is specifically activated by bacterial lipoproteins, such as LTA (lipoteichoic acid) and zymosan, and can be activated by synthetic bacterial lipopeptides (BLPs) consisting of tri- or di-palmitoyl- S
openaire   +2 more sources