Results 121 to 130 of about 63,490 (224)
Revving up dendritic cells while braking PD-L1 to jump-start the cancer-immunity cycle motor [PDF]
, 2016 Although it is successful for some, most melanoma patients are refractory to T cell checkpoint inhibition. In this issue of Immunity, Merad and colleagues (2016) describe a dendritic-cell-based strategy to heighten the efficacy of therapeutic anti-PD-L1 ...
Coffelt, Seth B., de Visser, Karin E.
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Histiocytes: Multifaceted Regulators of Health and Disease
Veterinary Clinical Pathology, EarlyView.ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley +1 more source
Virology JournalBackground To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells.
Jia Liu +4 more
doaj +1 more source
PLoS Pathogens, 2018 Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF.
Yisha Liang +5 more
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Advanced Healthcare Materials, Volume 15, Issue 11, 20 March 2026.Patient‐specific induced pluripotent stem cells (iPSCs) can be differentiated into alveolar type II cells (iAT2s), expanded as 3D alveolospheres, and grown at physiologically relevant air–liquid interface (ALI). This study shows for the first time the infectability of iAT2s by the influenza A virus (IAV) and proves their responsiveness to the well ...
Lena Gauthier +7 more
wiley +1 more source
Hormonal regulation of innate immune responses and toll-like receptors in the human endometrium [PDF]
Vita.The entire dissertation/thesis text is included in the research.pdf file; the official abstract appears in the short.pdf file (which also appears in the research.pdf); a non-technical general description, or public abstract, appears in the public ...
Lange, Margaret J., 1981-
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Matrix Stiffness Governs Fibroblasts’ Regulation of Gingival Immune Homeostasis
Advanced Materials, Volume 38, Issue 15, 12 March 2026.This study identifies a “mechano‐epigenetic” checkpoint in which matrix stiffness governs the immune responses of gingival fibroblasts. Using biomimetic hydrogels and human gingival explants, the studies revealed that restoring extracellular matrix stiffness actively suppresses inflammation via non‐canonical NF‐κB signaling and DNA methylation ...
Hardik Makkar +5 more
wiley +1 more source
Advanced Science, Volume 13, Issue 17, 23 March 2026.Tumor‐derived extracellular vesicles program inflammatory lung premetastatic niches through selective delivery of long noncoding RNAs. This work reveals EVs‐associated lncOSLMT as a key driver of lung fibroblast activation via m6A‐dependent PTGS2 stabilization.
Hongbo Li +10 more
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Clinical and Translational Medicine, Volume 16, Issue 3, March 2026.NINJ1 mediates PMR in cardiovascular cell death, releasing DAMPs that amplify vascular inflammation. Dual NINJ1 paradox: membrane‐bound form drives endothelial NF‐κB/CXCL‐8 inflammation while soluble form provides atheroprotection. Pericyte NINJ1 regulates the critical balance between angiogenic sprouting and vessel maturation in ischaemic tissues ...
Muhammad Mamunur Rashid Mahib
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Viral modulation of interferon (IFN) responses to african swine fever virus (ASFV) [PDF]
, 2011 Tese de mestrado. Biologia (Biologia Humana e Ambiente). Universidade de Lisboa, Faculdade de Ciências, 2011A imunidade inata constitui a primeira resposta dada por um hospedeiro quando atacado por agentes patogénicos. A resposta imune baseia-se em genes
Costa, Emanuel Nery de Oliveira Quartin, 1986-
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