Results 111 to 120 of about 46,970 (197)

Toll-Like Receptor 3 as a Recurrence Risk Factor and a Potential Molecular Therapeutic Target in Colorectal Cancer

open access: yesClinical and Experimental Gastroenterology, 2020
Tatsuya Yoshida,1 Takuya Miura,1 Tomoh Matsumiya,2 Hidemi Yoshida,2 Hajime Morohashi,1 Yoshiyuki Sakamoto,1 Akira Kurose,3 Tadaatsu Imaizumi,2 Kenichi Hakamada1 1Department of Gastroenterological Surgery, Hirosaki University Graduate School of Medicine ...
Yoshida T   +8 more
doaj  

Histiocytes: Multifaceted Regulators of Health and Disease

open access: yesVeterinary Clinical Pathology, EarlyView.
ABSTRACT The mononuclear phagocyte system encompasses macrophages, dendritic cells (DCs), and monocytes. Tissue‐resident macrophages and dendritic cells arise during embryogenesis and are replenished either through self‐renewal or by monocytes during inflammation.
Erika J. Gruber
wiley   +1 more source

TLR3 and TLR4 complex components.

open access: yes, 2015
For each of the three nonprotein molecules involved in forming TLR3 and TLR4 complexes, its name and identifier in the ChEBI reference database is given.
Peter D’Eustachio (727315)   +7 more
core   +1 more source

Warburg redefined: Metabolites, mitochondria and macrophages in immune regulation

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend Following pro‐inflammatory stimulation, macrophages undergo Warburg‐like metabolic rewiring that extends more than increased glycolysis. The non‐canonical functions of glycolytic enzymes and lactate accumulation control macrophage immune responses through multiple signalling pathways (a).
Yukun Min   +2 more
wiley   +1 more source

TLR3 Sensing of Viral Infection

open access: yes, 2010
Viral infection is detected by the innate immune system which mounts a rapid semi-selective defence involving inflammation and production of type 1 interferons.
Noel G McElvaney (7895978)   +2 more
core   +2 more sources

Cancer‐associated fibroblast heterogeneity across solid and haematological malignancies: Lessons from colorectal cancer and multiple myeloma

open access: yesThe Journal of Physiology, EarlyView.
Abstract figure legend CAF origins and plasticity give rise to distinct phenotypes with immunosuppressive functions in colorectal cancer and multiple myeloma. These distinct CAF phenotypes contribute to immunosuppressive tumour microenvironments through ECM remodelling, cytokine signalling and immune regulation.
Hui Mo   +4 more
wiley   +1 more source

TLR3 knock-out macrophages. Wild type and TLR3 knock-out macrophages were infected with DV1.

open access: yes, 2013
(A) Cell lysates and total RNA were collected for analysis. Immunoblotting (IB) and RT-PCR analysis show that DV1 infection is significantly higher in cell line deficient for TLR3.
Hui Hui Wong (358017)   +5 more
core   +1 more source

Nontumor‐Specific mRNA Sensitization of Cold Tumors to Immune Checkpoint Blockade: Evidence, Bias, and Requirements for Translation

open access: yesAdvanced Oncology, Volume 1, Issue 1, December 2026.
Messenger RNA constructs encoding nontumor antigens are proposed to sensitize cold tumors to checkpoint blockade. Observational survival estimates favor vaccination but are heterogeneous, and bias‐focused analyses find no significant difference once time‐zero is aligned. Epitope spreading remains undemonstrated in humans. This review separates what the
Sarfaraz K. Niazi
wiley   +1 more source

Plant‐Derived Probiotics From Fermented Foods: Current Evidence on Antiviral Mechanisms and Gut–Lung Axis Modulation

open access: yesFood Frontiers, Volume 7, Issue 6, November 2026.
Plant‐derived probiotics from fermented foods exert anti‐respiratory virus effects via immune regulation, antiviral metabolites, and gut–lung axis, highlighting their advantages, key technologies, and application prospects. ABSTRACT Respiratory viral infections represent a major global public health threat, causing widespread morbidity, mortality, and ...
Yinghao Xing   +6 more
wiley   +1 more source

The Role of Astrocytes in the Inflammatory Response in Neurodiseases

open access: yesMedComm, Volume 7, Issue 11, November 2026.
Reactive astrocyte‐mediated pathogenic mechanisms in neurodegenerative diseases Schematic representation of key astrocytic pathways contributing to pathology in the pathogenesis of AD, PD, ALS, and HD. In AD, astrocytes exhibit Aβ plaque‐associated activation characterized by GFAP/S100β upregulation, accompanied by impaired EAAT2‐mediated glutamate ...
Shijun Peng   +3 more
wiley   +1 more source

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