Results 121 to 130 of about 46,970 (197)

TLR3 downregulation in an escape mecanism to apoptosis durant hepatocarcinogenesis

, 2019
Introduction : Le récepteur TLR3 (Toll-like receptor 3) détecte l'ARN double brin viral ou cellulaire; il est exprimé dans les hépatocytes humains dans lesquels son activation engendre une réponse proinflammatoire médiée par la production d’interféron de
Fares, Nadim
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TLR3 Modulates the Response of NK Cells against Schistosoma japonicum

, 2018
Natural killer (NK) cells are classic innate immune cells that play roles in many types of infectious diseases. NK cells possess many kinds of TLRs that allow them to sense and respond to invading pathogens.
Lu Li, Jiale Qu, Xiaona Zhang, Jun Huang, Chenxi Jin, Hongyan Xie, Yuanfa Feng, Nuo Dong, Quan Yang, Huaina Qiu   +9 more
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Gastric Cancer: Epidemiology, Risk Factors, Pathogenesis, Clinical Features, Diagnosis, and Management

MedComm, Volume 7, Issue 11, November 2026.
This comprehensive review summarizes gastric cancer epidemiology, multifactorial risk factors (like infectious, dietary, genetic), pathogenesis such as precancerous evolution, molecular alterations, and a focus on the bidirectional interactions between gastric cancer cells and macrophages in the tumor microenvironment.
Yixuan Xin, Xingya Wang, Yangtao Wu, Qian Liu, Qian Ren, Hui Wang, Jingbo Zhai   +6 more
wiley   +1 more source

Immunoexpression pattern of TLR3 and TLR7 in minor salivary gland adenoid cystic carcinoma and its role in prognosis

Cancer Treatment and Research Communications
Objectives: Adenoid cystic carcinoma (ACC) of the salivary glands has poor long-term prognosis and a high metastatic rate. Toll-like receptors (TLRs), first-line immune activators, have been associated with both tumor progression and suppression.
Aleksi Rytkönen, Mine Eray, Auli Suominen, Antti Mäkitie, Caj Haglund, Jaana Hagström, Hanna K. Laine   +6 more
doaj   +1 more source

TLR3 signaling is required for ischemic preconditioning (IPC)- or Poly I:C preconditioning-induced protection in astrocytes.

, 2014
(A–C) Astrocyte cultures were treated with 10 µg/mL Poly I:C plus non-immune IgG or 50 ng/mL anti-TLR3 antibody (Ab-TLR3) 24 h before being subjected to 12-h oxygen-glucose deprivation (OGD).
Lian-jun Guo (575680), Qing Lu (28914), Yang Li (7082), Xu-lin Xu (575679), Jian Wang (5901), Lin-na Pan (575678), Wei Zhu (23646)   +6 more
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The Chlamydia-induced gene expression of the TJ proteins is impacted during TLR3 deficiency.

, 2019
Gene expression levels of ZO-1, JAM-1, and occludin were measured by qPCR at various times post-infection in C. muridarum infected WT, TLR3-deficient, and in TLR3-deficient OE cells that were pre-treated with 50U/ml recombinant IFN-β 1hr before infection.
Cheikh I. Seye (36991), Haoli Gong (6191333), Nicole Ramos-Solis (6191336), Luyao Liu (2819149), Ramesh Kumar (244395), Wilbert A. Derbigny (709506)   +5 more
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Placental TLR3/7/8 activation in pregnant mice.

, 2013
Fold-increase and representative images and densitometric analyses of TLR3, TLR7, and TLR8 mRNA and protein levels, respectively, from 4 independent experiments in mice treated with (A) the TLR3 agonist poly I:C and (B) the TLR7 agonist R837 and the TLR7/
Ajay M. Narayanan (313877), Shelley E. Kopriva (313874), Valorie L. Chiasson (313875), Thomas J. Kuehl (313880), Laura E. Weaver (313872), Kristina J. Young (313878), Kathleen A. Jones (313879), Samantha J. Allen (313876), Karen M. Doersch (313873), Piyali Chatterjee (313871), Brett M. Mitchell (313881)   +10 more
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TLR3 rs3775291 C/T polymorphism is associated with elevated IFN-α level in asymptomatic HTLV-1 infection

Frontiers in Cellular and Infection Microbiology
IntroductionAlterations in the immune response may influence the development of HTLV-1-associated diseases. TLR3 detects viral nucleic acids, including HTLV-1, and triggers the production of IFN-I and other cytokines. Genetic variations in TLR3 may alter
Fabiane dos Santos Ferreira, Fabiane dos Santos Ferreira, Wandrey Roberto dos Santos Brito, Wandrey Roberto dos Santos Brito, Emmanuelle Giuliana Mendes Santana, Aline Kelly Alves Oliveira, Aline Cecy Rocha de Lima, Aline Cecy Rocha de Lima, Ednelza da Silva Graça Amoras, Carlos Araujo da Costa, Maísa Silva Souza, Sandra Souza Lima, Ricardo Ishak, Izaura Maria Vieira Cayres-Vallinoto, Izaura Maria Vieira Cayres-Vallinoto, Antonio Carlos Rosário Vallinoto, Antonio Carlos Rosário Vallinoto, Maria Alice Freitas Queiroz, Maria Alice Freitas Queiroz   +18 more
doaj   +1 more source

TLR3 as a biomarker for the therapeutic efficacy of double-stranded RNA in breast cancer.

, 2011
International audienceThe discovery of a targeted therapeutic compound along with its companion predictive biomarker is a major goal of clinical development for a personalized anticancer therapy to date.
Massacrier, C., Dubois, C., Dubois, Clarisse, Zitvogel, Laurence, Fabrice Andre, Asselin-Paturel, Carine, Rosa Conforti, Sabourin, Jean-Christophe, Morel, Yannis, Lebecque, Serge, Clarisse Dubois, Conforti, R., Lebecque, S., Salaun, B., Zitvogel, L., Morel, Y., Aicha Goubar, Karine Chemin, Bruno Salaun, Romero, P., Chenard, M.P., Sabourin, J.C., Pedro Romero, Laurence Zitvogel, Pierres, M., Chemin, Karine, Conforti, Rosa, Pierres, Michel, Marie Pierre Chenard, Salaun, Bruno, André, Fabrice, Goubar, A., Donata Rimoldi, Chenard, Marie Pierre, Michel Pierres, Serge Lebecque, Asselin-Paturel, C., Rimoldi, Donata, Carine Asselin-Paturel, Catherine Massacrier, Jean-Christophe Sabourin, Chemin, K., Andre, F., Massacrier, Catherine, Goubar, Aicha, Yannis Morel, Romero, Pedro, Rimoldi, D., Morel Y, Pierres M, Dubois C, Asselin-Paturel C, Goubar A, Andre F, Chenard MP, Conforti R, Salaun B, Massacrier C, Romero P, Rimoldi D, Zitvogel L, Sabourin JC, Lebecque S, Chemin K   +63 more
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草鱼BAC文库中TLR3基因的筛选及表达特征的研究

, 2010
【目的】从草鱼的BAC文库中筛选TLR3基因的阳性克隆,研究该基因在草鱼体内的表达规律,为进一步研究奠定基础。【方法】用同位素P32标记的探针,对53 216个BAC克隆以双份平行形式制备的DNA尼龙膜进行杂交筛选,用半定量方法检测TLR3在草鱼不同组织(鳃、心脏、肠、肝胰脏、肌肉、皮肤、脾脏、头肾和中肾)中的表达模式,用实时荧光定量RT-PCR研究草鱼感染呼肠孤病毒后不同时间TLR3的表达规律。【结果】获得了2个TLR3基因的阳性BAC克隆,该基因在被检测的9个组织中都有表达,其中在脾脏 ...
汪亚平, 苏建国, 董捷, 张荣芳, 杨春荣, 张成勋   +5 more
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