Results 91 to 100 of about 63,928 (200)

A20 (Tnfaip3) deficiency in myeloid cells protects against influenza A virus infection [PDF]

, 2012
The innate immune response provides the first line of defense against viruses and other pathogens by responding to specific microbial molecules. Influenza A virus (IAV) produces double-stranded RNA as an intermediate during the replication life cycle ...
Maelfait, Jonathan, Roose, Kenny, Bogaert, Pieter, Sze, Mozes, Saelens, Xavier, Pasparakis, Manolis, Carpentier, Isabelle, van Loo, Geert, Beyaert, Rudi   +8 more
core   +2 more sources

Avian Toll-like receptor 3 isoforms and evaluation of Toll-like receptor 3–mediated immune responses using knockout quail fibroblast cells

Poultry Science, 2020
Toll-like receptor 3 (TLR3) induces host innate immune response on recognition of viral double-stranded RNA (dsRNA). Although several studies of avian TLR3 have been reported, none of these studies used a gene knockout (KO) model to directly assess its ...
Mahesh KC, John M. Ngunjiri, Joonbum Lee, Jinsoo Ahn, Mohamed Elaish, Amir Ghorbani, Michael E.C. Abundo, Kichoon Lee, Chang-Won Lee   +8 more
doaj   +1 more source

Global Transcriptomic Profiling of Bovine Endometrial Immune Response In Vitro. II. Effect of Bovine Viral Diarrhea Virus on the Endometrial Response to Lipopolysaccharide [PDF]

, 2015
Infection with noncytopathic bovine viral diarrhea virus (ncpBVDV) is associated with uterine disease and infertility. This study investigated the influence of ncpBVDV on immune functions of the bovine endometrium by testing the response to bacterial ...
Abudureyimu, A, Anstaett, O L, Brownlie, J, Cheng, Z R, Fouladi-Nashta, A A, Oguejiofor, C F, Wathes, D C   +6 more
core   +2 more sources

Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB

Scientific Reports, 2017
Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells.
Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Yongxiu Yao, Venugopal Nair, Aijian Qin   +8 more
doaj   +1 more source

Toll-Like Receptor 3 Is Involved in Detection of Enterovirus A71 Infection and Targeted by Viral 2A Protease

Viruses, 2018
Enterovirus A71 (EV-A71) has emerged as a major pathogen causing hand, foot, and mouth disease, as well as neurological disorders. The host immune response affects the outcomes of EV-A71 infection, leading to either resolution or disease progression ...
Kuan-Ru Chen, Chun-Keung Yu, Szu-Hao Kung, Shun-Hua Chen, Chuan-Fa Chang, Tzu-Chuan Ho, Yi-Ping Lee, Hung-Chuan Chang, Lan-Yin Huang, Shih-Yen Lo, Jui-Chung Chang, Pin Ling   +11 more
doaj   +1 more source

Vaccinia protein C16 blocks innate immune sensing of DNA by binding the Ku complex [PDF]

, 2011
VACV gene C16L encodes a 37-kDa protein that is highly conserved in orthopoxviruses and functions as an immunomodulator. Intranasal infection of mice with a virus lacking C16L (vΔC16) induced less weight loss, fewer signs of illness and increased ...
Peters, Nicholas Edward, Peters, Nicholas Edward   +1 more
core   +1 more source

Toll-like receptor 3 activation enhances antitumor immune response in lung adenocarcinoma through NF-κB signaling pathway

Frontiers in Immunology
BackgroundToll-like receptor 3 (TLR3) is a pattern recognition receptor known to play a crucial role in the immune response to cancer. However, its effect on the efficacy of immunotherapy in lung adenocarcinoma (LUAD) remains unclear.
Ang Li, Ang Li, Ang Li, Man Luo, Xiyao Liu, Hongjiao Wu, Hongjiao Wu, Hongjiao Wu, Xiaoguang Liu, Zhi Zhang, Xuemei Zhang, Xuemei Zhang, Xuemei Zhang   +12 more
doaj   +1 more source

Hepatitis C virus NS4B induces the degradation of TRIF to inhibit TLR3-mediated interferon signaling pathway.

PLoS Pathogens, 2018
Toll-like receptor 3 (TLR3) senses dsRNA intermediates produced during RNA virus replication to activate innate immune signaling pathways through adaptor protein TRIF.
Yisha Liang, Xuezhi Cao, Qiang Ding, Yanan Zhao, Zhenliang He, Jin Zhong   +5 more
doaj   +1 more source

HSV-1 immune escapes in microglia by down-regulating GM130 to inhibit TLR3-mediated innate immune responses

Virology Journal
Background To investigate the mechanism of Golgi matrix protein 130(GM130) regulating the antiviral immune response of TLR3 after herpes simplex virus type 1(HSV-1) infection of microglia cells.
Jia Liu, Xiqian Chen, Junxian Liu, Hainan Zhang, Wei Lu   +4 more
doaj   +1 more source

Helminth Infections: Recognition and Modulation of the Immune Response by Innate Immune Cells [PDF]

, 2018
The survival of helminths in the host over long periods of time is the result of a process of adaptation or dynamic co-evolution between the host and the parasite. However, infection with helminth parasites causes damage to the host tissues producing the
Ambrosio, Laura Fernanda, Celias, Daiana Pamela, Cervi, Laura Alejandra, Chiapello, Laura Silvina, Motran, Claudia Cristina, Silvane, Leonardo Micael, Theumer, Martín Gustavo, Volpini, Ximena   +7 more
core   +1 more source