Results 71 to 80 of about 46,970 (197)

Modest antiviral activity of Toll-like receptor 3 (TLR3) against [PDF]

Human respiratory syncytial virus (RSV) is the leading cause of acute lower respiratory infections in infants and Toll-like receptors (TLRs) are the first line of host defense against such infections.
IGARASHI-OKITA, Lisa, WATANABE, Kazuto, YOTO, Yuko, TSUTSUMI, Hiroyuki, NAGAI, Kazushige, HORI, Tsukasa, TSUGAWA, Takeshi   +6 more
core   +2 more sources

Extracellular Vesicles‐Based Biological Macromolecule Delivery Systems: Biogenesis, Characterization, and Emerging Clinical Applications

Biotechnology and Bioengineering, EarlyView.
ABSTRACT Extracellular vesicles (EVs) are nanoscale membrane‐bound structures that play a pivotal role in intercellular communication by transporting bioactive molecules, including proteins, lipids, nucleic acids, and organelles, between cells. Originating from the endosomal pathway, EVs reflect the physiological and pathological status of their parent
Emine İncilay Torunoğlu, Zeynep Betül Sarı, Muhammed Emin Sarı, Erdi Can Aytar   +3 more
wiley   +1 more source

Einfluss von TLR3 auf die Epithelial-Mesenchymale Transition in Kopf-Hals-Tumoren

, 2016
Einleitung: Als Grundvoraussetzung für den Metastasierungsprozess von Kopf-Hals-Tumoren wird die Epithelial-Mesenchymale Transition (EMT) angenommen. Bei Dysregulation, z.B.
Hell, H, Pries, R, Wollenberg, B
core   +1 more source

TLR3 activation mediates partial epithelial-to-mesenchymal transition in human keratinocytes

Life Science Alliance
TLR3 signaling in normal healthy keratinocytes activates a partial EMT response with enhanced migration and invasion properties, supporting a broader role of TLR3 in cell developmental programming beyond its role in innate immune response and ...
Andrea M Schneider, Robert P Feehan, Mackenzie L Sennett, Carson A Wills, Charlotte Garner, Zhaoyuan Cong, Elizabeth M Billingsley, Alexandra F Flamm, Lisa M Shantz, Amanda M Nelson   +9 more
doaj   +1 more source

Nanoagonist‐mediated spatiotemporal reprogramming of macrophage phenotypes to potentiate tumor immunotherapy

BMEMat, EarlyView.
This review systematically summarizes the major molecular mechanisms governing TAM polarization and their coordinated interactions. It further highlights recent advances in nanoagonist‐based strategies that intervene in these pathways to reprogram TAMs, critically discussing their therapeutic potential, current limitations, and translational prospects.
Siqi Fang, Fengfeng Xiao, Ruie Chen, Cuixia Lu, Yi Ju, Mingqing Yuan, Yunlu Dai, Liewei Wen   +7 more
wiley   +1 more source

TLR3 deficiency in patients with herpes simplex encephalitis.

, 2007
International audienceSome Toll and Toll-like receptors (TLRs) provide immunity to experimental infections in animal models, but their contribution to host defense in natural ecosystems is unknown.
Sancho-Shimizu, Vanessa, Ugolini, Sophie, Lebon, Pierre, Rozenberg, Flore, Casrouge, Armanda, Geissmann, Frédéric, Ku, Cheng-Lung, Lorenzo, Lazaro, Chapgier, Ariane, Hovnanian, Alain, Vallée, Louis, Titeux, Matthias, Zhang, Xin-Xin, Tardieu, Marc, Leonard, Joshua, Segal, David, Héron, Bénédicte, Zhang, Shen-Ying, Hamilton, Claire, Puel, Anne, Barreiro, Luis, Elain, Gaëlle, Quintana-Murci, Lluis, Vivier, Eric, Jouanguy, Emmanuelle, Abel, Laurent, Casanova, Jean-Laurent, Smahi, Asma, Picard, Capucine, Cognet, Céline, von Bernuth, Horst, Romero, Pedro, Plancoulaine, Sabine, Titeux, M., Jouanguy, E., Ugolini, S., von Bernuth, H., Lebon, P., Casanova, J.L., Leonard, J., Cognet, C., Picard, C., Quintana-Murci, L., Romero, P., Elain, G., Barreiro, L., Plancoulaine, S., Zhang, S.Y., Ku, C.L., Hamilton, C., Smahi, A., Segal, D., Vallée, L., Abel, L., Geissmann, F., Hovnanian, A., Rozenberg, F., Vivier, E., Zhang, X.X., Chapgier, A., Sancho-Shimizu, V., Héron, B., Tardieu, M., Lorenzo, L., Puel, A., Casrouge, A.   +65 more
core   +1 more source

“Nature's Polymer Reimagined: Conventional and Green Routes to Pectin, Its Bioactive Promise and Industrial Applications”

Food Chemistry International, EarlyView.
Pectin, a versatile natural polymer, is extracted through conventional and emerging green extraction methods, offering multifunctional bioactive properties useful in food, pharmaceutical, and environmental applications. ABSTRACT Pectin, a molecular tapestry woven from diverse polysaccharides, holds a pivotal role across food, pharmaceutical, and ...
Afra Anika Rafique, Aunwesha Sahani, Md Morsaline Billah, Kazi Mohammed Didarul Islam   +3 more
wiley   +1 more source

Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-κB

Scientific Reports, 2017
Toll-like receptor-3 (TLR3), a member of the pathogen recognition receptor family, has been reported to activate immune response and to exhibit pro-apoptotic activity against some tumor cells.
Haitao Zou, Ruixue Su, Jing Ruan, Hongxia Shao, Kun Qian, Jianqiang Ye, Yongxiu Yao, Venugopal Nair, Aijian Qin   +8 more
doaj   +1 more source

Research progress on the role of inflammatory mediators in the pathogenesis of epilepsy

Ibrain, Volume 11, Issue 1, Page 44-58, Spring 2025.
In the central nervous system, activated immune cells lead to the overproduction of inflammatory mediators through the corresponding signal pathway. Under the stimulation of inflammatory factors, neuroinflammation ultimately occurs. Overexpression of inflammatory mediators and activated immunocytes plays an important role in the emergence and ...
Yue Yu, Fei‐Ji Sun
wiley   +1 more source

Combating herpesvirus encephalitis by potentiating a TLR3–mTORC2 axis

, 2018
TLR3 is a sensor of double-stranded RNA that is indispensable for defense against infection with herpes simplex virus type 1 (HSV-1) in the brain. We found here that TLR3 was required for innate immune responses to HSV-1 in neurons and astrocytes. During
Kawaguchi, Yasushi, Yusuke Murakami, Kato, Akihisa, Manabe, Toshiya, Wada, Yoh, Takahiko Chimura, Ikenoue, Tsuneo, Miyake, Kensuke, Ge-Hong Sun-Wada, Yasushi Kawaguchi, Ryota Sato, Yoh Wada, Tsuneo Ikenoue, Ryutaro Fukui, Glen N. Barber, Barber, Glen N, Liu, Kaiwen, Sun-Wada, Ge-Hong, Toshiya Manabe, Kensuke Miyake, Zhang, Yun, Jun Arii, Arii, Jun, Sato, Ryota, Shibata, Takuma, Shin-Ichiroh Saitoh, Kaiwen Liu, Akihisa Kato, Takuma Shibata, Murakami, Yusuke, Saitoh, Shin-Ichiroh, Chimura, Takahiko, Yun Zhang, Fukui, Ryutaro   +33 more
core   +1 more source