Results 51 to 60 of about 63,928 (200)
Trial watch: TLR3 agonists in cancer therapy [PDF]
OncoImmunology, 2020 Toll-like receptor 3 (TLR3) is a pattern recognition receptor that senses exogenous (viral) as well as endogenous (mammalian) double-stranded RNA in endosomes. On activation, TLR3 initiates a signal transduction pathway that culminates with the secretion of pro-inflammatory cytokines including type I interferon (IFN).
Naour, Julie Le +4 more
openaire +3 more sources
Trakya University Journal of Natural SciencesMesenchymal stem cells (MSCs) are progenitor cells isolated from various tissues and are crucial for tissue repair, immune support, and anticancer therapies.
Ayşegül Yılmaz, Demet Kaçaroğlu
doaj +1 more source
Respiratory antiviral immunity and immunobiotics: Beneficial effects on inflammation-coagulation interaction during influenza virus infection [PDF]
, 2016 Influenza virus (IFV) is a major respiratory pathogen of global importance, and the cause of a high degree of morbidity and mortality, especially in high-risk populations such as infants, elderly, and immunocompromised hosts.
Alvarez, Gladis Susana +3 more
core +1 more source
Coagulation Disorders in COVID-19: Role of Toll-like Receptors
Journal of Inflammation Research, 2020 Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National ...
Biswas I, Khan GA
doaj
Toll like receptor 3 plays a critical role in the progression and severity of acetaminophen-induced hepatotoxicity. [PDF]
PLoS ONE, 2013 Toll-like receptor (TLR) activation has been implicated in acetaminophen (APAP)-induced hepatotoxicity. Herein, we hypothesize that TLR3 activation significantly contributed to APAP-induced liver injury.
Karen A Cavassani +13 more
doaj +1 more source
Modeling viral infectious diseases and development of antiviral therapies using human induced pluripotent stem cell-derived systems [PDF]
, 2015 The recent biotechnology breakthrough of cell reprogramming and generation of induced pluripotent stem cells (iPSCs), which has revolutionized the approaches to study the mechanisms of human diseases and to test new drugs, can be exploited to generate ...
Barzon, Luisa +6 more
core +2 more sources
Roles of the Cleaved N-Terminal TLR3 Fragment and Cell Surface TLR3 in Double-Stranded RNA Sensing [PDF]
The Journal of Immunology, 2014 Abstract TLR3 senses viral dsRNA in endolysosomes. The TLR3 ectodomain is cleaved by proteases such as cathepsins in endolysosomes. It remains controversial whether the N-terminal fragment of TLR3 ectodomain (TLR3N) is cleaved off or remains associated with the C-terminal TLR3 fragment (TLR3C).
Yusuke, Murakami +7 more
openaire +2 more sources
MDA5 complements TLR3 in suppression of neuroblastoma
Oncotarget, 2015 Toll-like receptor3 (TLR3) has been confirmed to be differentially expressed in neuroblastoma (NB), and predicts a favorable prognosis with a high expression in tumor tissues. Treatment with TLR3 agonist--polyinosinic-polycytidylic acid [poly(I:C)] could induce significant but limited apoptosis in TLR3-expressing NB cells, suggesting that other viral ...
Wen-Ming, Hsu +7 more
openaire +3 more sources
Biomedicines, 2022 The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3 ...
Sara Bodahl +3 more
doaj +1 more source
Toll-like receptor-mediated signaling cascade as a regulator of the inflammation network during alcoholic liver disease [PDF]
, 2014 Chronic abuse of alcohol leads to various histological abnormalities in the liver. These are conditions collectively known as alcoholic liver disease (ALD). Currently, ALD is considered to be one of the major causes of death worldwide.
Alisi, A., Ceccarelli, S, Nobili, V
core +1 more source