Results 61 to 70 of about 46,970 (197)
TLR3/7/8 activation in human trophoblasts.
, 2013 Representative images and densitometric analyses of TLR3, TLR7, and TLR8 protein levels from 4 independent experiments for (A) the TLR3 agonist poly I:C, (B) the TLR7 agonist R837, and (C) the TLR7/8 agonist CLO97.
Ajay M. Narayanan (313877) +10 more
core +1 more source
Frontiers in Immunology, 2019 Although mesenchymal stromal cells (MSCs) are among the most promising cell sources for cell-based therapies and regenerative medicine, the decline in their function with age due to cellular senescence limits their therapeutic applications. Unveiling the
Hyang Ju Lee +15 more
doaj +1 more source
Poly(I:C)‐Activated Nasal Fibroblasts Promote Eosinophil Recruitment in CRSwNP
International Forum of Allergy &Rhinology, EarlyView.ABSTRACT Background Chronic rhinosinusitis with nasal polyps (CRSwNP) is characterized by persistent mucosal inflammation and eosinophilic infiltration. Although epithelial and immune cells have been widely studied, the role of nasal fibroblasts in innate immune activation and eosinophil recruitment remains unclear.
Chaewon Shin +5 more
wiley +1 more source
Differences in gene regulation by TLR3 and IPS-1 signaling in murine corneal epithelial cells
Scientific Reports, 2023 Toll-like receptor 3 (TLR3) and interferon-beta promoter stimulator-1 (IPS-1) are associated with antiviral responses to double-stranded RNA viruses and contribute to innate immunity.
Seitaro Komai +6 more
doaj +1 more source
Advanced NanoBiomed Research, EarlyView.Engineered endotoxin‐free Escherichia coli were used to assemble poly(3‐hydroxybutyrate) (PHB) biopolymer particles displaying multiple conserved Burkholderia pseudomallei antigens via PhaC‐mediated surface presentation. Following formulation with poly(I:C), the particulate vaccines induced antigen‐specific humoral and cellular immune responses ...
Md. Tanvir Kabir +6 more
wiley +1 more source
Small-Molecule Inhibitors of the TLR3/dsRNA Complex
, 2016 The protein−RNA interface has been regarded as “undruggable” despite its importance in many biological processes. The toll-like receptor 3 (TLR3)/double-stranded RNA (dsRNA) complex provides an exciting target for a number of infectious diseases and ...
Kui Cheng (2182816) +2 more
core +1 more source
MDA5 complements TLR3 in suppression of neuroblastoma
, 2017 Toll-like receptor3 (TLR3) has been confirmed to be differentially expressed in neuroblastoma (NB), and predicts a favorable prognosis with a high expression in tumor tissues.
Hsu, Wen-Ming;Huang, Chao-Cheng;Lee, Hsin-Yu;Wu, Pei-Yi;Wu, Min-Tsui;Chuang, Hui-Ching;Lin, Li-Ling;Chuang, Jiin-Haur +1 more
core +1 more source
Toll-like receptor 3 (TLR3) plays a major role in the formation of rabies virus Negri Bodies. [PDF]
PLoS Pathogens, 2009 Human neurons express the innate immune response receptor, Toll-like receptor 3 (TLR3). TLR3 levels are increased in pathological conditions such as brain virus infection.
Pauline Ménager +8 more
doaj +1 more source
The Role of miRNAs in Chicken Immune Regulation and Prospects for Disease‐Resistant Breeding
Animal Research and One Health, EarlyView.A schematic workflow illustrating the screening of disease‐resistant miRNAs and the generation of miRNA‐based disease‐resistant chickens via PGC‐mediated germline genome editing. ABSTRACT MicroRNAs (miRNAs) are emerging as pivotal regulators of the immune system, playing a decisive role in shaping disease resistance in chicken.
Qiangzhou Wang +10 more
wiley +1 more source
MDL‐800‐induced SIRT6 activation decreases age‐associated osteoarthritis in mice
Arthritis &Rheumatology, Accepted Article.Objective SIRT6 is a nuclear‐localized histone deacetylase that regulates multiple pathways associated with aging. This study aimed to determine whether systemic administration of a small molecule activator of SIRT6, MDL‐800, decreases the severity of age‐associated osteoarthritis (OA) in mice.
Matheus Moreira Perez +13 more
wiley +1 more source