Results 31 to 40 of about 46,970 (197)

Bufalin Suppresses Migration and Invasion of Hepatocellular Carcinoma Cells Elicited by Poly (I:C) Therapy

OncoImmunology, 2018
The Toll-like receptor 3 (TLR3) agonists as polyriboinosinic–polyribocytidylic acid (poly (I:C)) have been implicated as potential immunotherapy adjuvant for cancer whereas the exact roles of TLR3 agonists in hepatocellular carcinoma (HCC) treatment have
Yinglu Feng, Yongan Chen, Yongbin Meng, Qingxin Cao, Qun Liu, Changquan Ling, Chen Wang   +6 more
doaj   +1 more source

Toll-like receptor 3 modulates the behavioral effects of cocaine in mice

Journal of Neuroinflammation, 2018
Background The nucleus accumbens in the midbrain dopamine limbic system plays a key role in cocaine addiction. Toll-like receptors (TLRs) are important pattern-recognition receptors (PPRs) in the innate immune system that are also involved in drug ...
Ruiming Zhu, Qian Bu, Dengqi Fu, Xue Shao, Linhong Jiang, Wei Guo, Bo Chen, Bin Liu, Zhengtao Hu, Jingwei Tian, Yinglan Zhao, Xiaobo Cen   +11 more
doaj   +1 more source

Myeloid Differentiation Primary Response 88–Cyclin D1 Signaling in Breast Cancer Cells Regulates Toll-Like Receptor 3-Mediated Cell Proliferation

Frontiers in Oncology, 2020
Toll-like receptor 3 (TLR3)-mediated apoptotic changes in cancer cells are well-documented, and hence, several synthetic ligands of TLR3 are being used for adjuvant therapy, but there are reports showing a contradictory effect of TLR3 signaling, which ...
Aradhana Singh, Ranjitsinh Devkar, Anupam Basu   +2 more
doaj   +1 more source

Viral double-strand RNA-binding proteins can enhance innate immune signaling by toll-like Receptor 3. [PDF]

PLoS ONE, 2011
Toll-like Receptor 3 (TLR3) detects double-stranded (ds) RNAs to activate innate immune responses. While poly(I:C) is an excellent agonist for TLR3 in several cell lines and in human peripheral blood mononuclear cells, viral dsRNAs tend to be poor ...
Yvonne Lai, Guanghui Yi, Alice Chen, Kanchan Bhardwaj, Brady J Tragesser, Rodrigo A Valverde, Adam Zlotnick, Suchetana Mukhopadhyay, C T Ranjith-Kumar, C Cheng Kao   +9 more
doaj   +1 more source

LUBAC deficiency perturbs TLR3 signaling to cause immunodeficiency and autoinflammation [PDF]

, 2016
The linear ubiquitin chain assembly complex (LUBAC), consisting of SHANK-associated RH-domain–interacting protein (SHARPIN), heme-oxidized IRP2 ubiquitin ligase-1 (HOIL-1), and HOIL-1–interacting protein (HOIP), is a critical regulator of inflammation ...
Torsten Hartwig, Rieser, E, Endres, C, Peltzer, N, Lucia Taraborrelli, Johannes Lemke, Darding, M, Lemke, J, Draber, P, Ren, H, Taraborrelli, L, Cornelia Endres, Michael Bergmann, Ferguson, BJ, Peter Draber, Brian J. Ferguson, Balazs Dome, Nieves Peltzer, Kovacs, I, Dome, B, Zinngrebe, J, Maurice Darding, Henning Walczak, Hartwig, T, Walczak, H, Julia Zinngrebe, Eva Rieser, Hongwei Ren, Silvia von Karstedt, von Karstedt, S, Ildikó Kovács, Bergmann, M   +31 more
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Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. [PDF]

PLoS ONE, 2011
Toll-like receptor 3 (TLR3) signaling has been implicated in neural stem/precursor cell (NPC) proliferation. However, the molecular mechanisms involved, and their relationship to classical TLR-mediated innate immune pathways, remain unknown.
Kavitha Yaddanapudi, Joari De Miranda, Mady Hornig, W Ian Lipkin   +3 more
doaj   +1 more source

LL-37 and Double-Stranded RNA Synergistically Upregulate Bronchial Epithelial TLR3 Involving Enhanced Import of Double-Stranded RNA and Downstream TLR3 Signaling

Biomedicines, 2022
The human host defense peptide LL-37 influences double-stranded RNA signaling, but this process is not well understood. Here, we investigate synergistic actions of LL-37 and synthetic double-stranded RNA (poly I:C) on toll-like receptor 3 (TLR3 ...
Sara Bodahl, Samuel Cerps, Lena Uller, Bengt-Olof Nilsson   +3 more
doaj   +1 more source

Toll-like receptor 3-mediated modulation of umbilical cord mesenchymal stem cell phenotype and pancreatic cancer cell responses during coculture

Trakya University Journal of Natural Sciences
Mesenchymal stem cells (MSCs) are progenitor cells isolated from various tissues and are crucial for tissue repair, immune support, and anticancer therapies.
Ayşegül Yılmaz, Demet Kaçaroğlu
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TLR3 deficiency caused severe clonorchiasis in C.

, 2023
sinensis-infected mouse. (A) TLR3 expression in C. sinensis-infected mouse liver. The transcription levels of TLR3 in liver of WT and TLR3-/- mice were detected by RT-qPCR and normalized to GAPDH. (B) The weight changes of C.
Pengtao Gong (4055521), Yeting Ma (14498201), Xin Li (51274), Jianhua Li (36075), Nan Zhang (46264), Xu Zhang (49484), Yuru Wang (846969), Xiaocen Wang (4055518), Yanhui Yu (7323035), Haoyang Zhang (1706815), Xuancheng Zhang (10310258), Xichen Zhang (306024)   +11 more
core   +1 more source

Coagulation Disorders in COVID-19: Role of Toll-like Receptors

Journal of Inflammation Research, 2020
Indranil Biswas,1 Gausal A Khan2 1Cardiovascular Biology Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK 73104, USA; 2Department of Physiology & Physiotherapy, College of Medicine, Nursing and Health Sciences, Fiji National ...
Biswas I, Khan GA
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