Effect of dsRNA on Mesangial Cell Synthesis of Plasminogen Activator Inhibitor Type 1 and Tissue Plasminogen Activator [PDF]
, 2009 Background/Aims: Viral infections are a major problem worldwide and many of them are complicated by virally induced glomerulonephritides. Progression of kidney disease to renal failure is mainly attributed to the development of renal fibrosis ...
Merkle, Monika +4 more
core +1 more source
TLR3 agonists and proinflammatory antitumor activities [PDF]
Expert Opinion on Therapeutic Targets, 2013 Although tumor growth leads to inflammatory responses, the immune system develops tolerance to cancer. One way to break host tolerance to tumors is to activate key immune effector activities. Toward this end, various adjuvants are under investigation in an effort to harness the immune system to overcome tolerance to tumor-associated self-antigens ...
Sherven, Sharma +7 more
openaire +2 more sources
Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. [PDF]
PLoS ONE, 2009 Toll-like receptor 3 (TLR3) has been proposed to play a central role in the early recognition of viruses by sensing double stranded RNA, a common intermediate of viral replication.
Martin J Richer +3 more
doaj +1 more source
Frontiers in Immunology, 2021 Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction.
Chiung-Ya Chen +7 more
doaj +1 more source
TLR3 Sensing of Viral Infection [PDF]
The Open Infectious Diseases Journal, 2010 Viral infection is detected by the innate immune system which mounts a rapid semi-selective defence involving inflammation and production of type 1 interferons. Several sensors, both cell surface and intracellular, exist to detect different types of viral motifs.
F. Dunlevy +2 more
openaire +3 more sources
Immunomodulatory Effect of Toll-Like Receptor-3 Ligand Poly I:C on Cortical Spreading Depression [PDF]
, 2009 The release of inflammatory mediators following cortical spreading depression (CSD) is suggested to play a role in pathophysiology of CSD-related neurological disorders.
Aghabarari, A. +8 more
core +2 more sources
Cross-disease innate gene signature: Emerging diversity and abundance in RA comparing to SLE and SSc [PDF]
, 2019 Overactivation of the innate immune system together with the impaired downstream pathway of type I interferon-responding genes is a hallmark of rheumatoid arthritis (RA), systemic lupus erythematosus (SLE), and systemic sclerosis (SSc).
Fillerová, Regina +8 more
core +1 more source
Journal of Inflammation Research, 2022 Ruibing Su,1,* Lijun Cai,1,* Pan Xiong,1,* Zhiwei Liu,1,* Shaobin Chen,2 Xi Liu,1 Runhua Lin,1 Zhijin Lei,1 Dongping Tian,1 Min Su1 1Institute of Clinical Pathology, Department of Pathology, Shantou University Medical College, Shantou ...
Su R +9 more
doaj
Activation of interferon regulatory factor-3 via toll-like receptor 3 and immunomodulatory functions detected in A549 lung epithelial cells exposed to misplaced U1-snRNA [PDF]
, 2009 U1-snRNA is an integral part of the U1 ribonucleoprotein pivotal for pre-mRNA splicing. Toll-like receptor (TLR) signaling has recently been associated with immunoregulatory capacities of U1-snRNA.
C. D. Sadik +59 more
core +1 more source
Toll-like receptor 3 regulates neural stem cell proliferation by modulating the Sonic Hedgehog pathway. [PDF]
PLoS ONE, 2011 Toll-like receptor 3 (TLR3) signaling has been implicated in neural stem/precursor cell (NPC) proliferation. However, the molecular mechanisms involved, and their relationship to classical TLR-mediated innate immune pathways, remain unknown.
Kavitha Yaddanapudi +3 more
doaj +1 more source