Results 11 to 20 of about 46,970 (197)

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells [PDF]

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +3 more sources

The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

Cell Death Discovery, 2023
Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and ...
Joseph Bisaccia, Swann Meyer, Adrien Bertrand-Chapel, Quentin Hecquet, Virginie Barbet, Bastien Kaniewski, Sophie Léon, Nicolas Gadot, Isabelle Rochet, Iveta Fajnorova, Pierre Leblond, Martine Cordier-Bussat, Nadège Corradini, Alexandre Vasiljevic, Marc Billaud, Cécile Picard, Laura Broutier, Cindy Gallerne, Aurélie Dutour, Jean-Yves Blay, Marie Castets   +20 more
doaj   +2 more sources

TLR3 Plays Significant Roles against HBV-Associated HCC [PDF]

Gastroenterology Research and Practice, 2015
Toll-like receptor 3 (TLR3) is a pattern-recognizing receptor that is involved in immune signaling and plays a crucial role in survival by being able to recognize various viral components including double-stranded RNA (dsRNA).
Xiao-lan Chen, Yu-yin Xu, Li Chen, Gui-lan Wang, Yin Shen   +4 more
doaj   +2 more sources

Chlamydia trachomatis benötigt TLR3 der Wirtszelle für eine erfolgreiche Replikation [PDF]

, 2023
Das obligat intrazelluläre Bakterium Chlamydia trachomatis Serovar D ist der Erreger einer der häufigsten Geschlechtskrankheiten weltweit und kann bei Frauen zu Infertilität führen.
Kellner, Lina
core   +1 more source

TLR3-MEBV docked complex shown at the left in cartoon representation.

, 2021
Interacting residues of MEBV are highlighted at right side. MEBV construct revealed with blue color and TLR3 displayed with red color. Red lines represent salt bridges, blue lines show Hydrogen bonds, whilst orange lines demonstrate the other contacts in
Usman Ali Ashfaq (9386004), Nida Fatima Ali (11614175), Farah Shahid (9385998), Mohsin Khurshid (8966615), Muhammad Hamza Tariq (11614172), Rashid Bhatti (10090683), Ahmad Almatroudi (9709421)   +6 more
core   +1 more source

TLR3-Dependent Activation of TLR2 Endogenous Ligands via the MyD88 Signaling Pathway Augments the Innate Immune Response. [PDF]

, 2020
The role of the adaptor molecule MyD88 is thought to be independent of Toll-like receptor 3 (TLR3) signaling. In this report, we demonstrate a previously unknown role of MyD88 in TLR3 signaling in inducing endogenous ligands of TLR2 to elicit innate ...
Hellen S. Teixeira, Denis F. Kinane, Kinane, Denis F, Teixeira, Hellen S, Jiawei Zhao, Kazmierski, Ethan, Benakanakere, Manjunatha R, Ethan Kazmierski, Zhao, Jiawei, Manjunatha R. Benakanakere, Teixeira HS, Benakanakere MR, Kinane DF, Zhao J, Kazmierski E   +14 more
core   +2 more sources

Comparisons of the RMSD, RMSF values and the number of hydrogen bonds present in the structure of MEBV-TLR3 and TLR3 protein, obtained through MD simulation.

, 2021
(A) RMSD of the backbone of the MEBV-TLR3 and the TLR3 Protein (B) RMSF of the backbone of the complex and the TLR3 protein (C) Hydrogen bonds present in the MEBV-TLR3 complex and the TLR3 Proteins.
Usman Ali Ashfaq (9386004), Nida Fatima Ali (11614175), Farah Shahid (9385998), Mohsin Khurshid (8966615), Muhammad Hamza Tariq (11614172), Rashid Bhatti (10090683), Ahmad Almatroudi (9709421)   +6 more
core   +1 more source

Class A scavenger receptor 1 (MSR1) restricts hepatitis C virus replication by mediating toll-like receptor 3 recognition of viral RNAs produced in neighboring cells [PDF]

, 2013
Persistent infections with hepatitis C virus (HCV) may result in life-threatening liver disease, including cirrhosis and cancer, and impose an important burden on human health.
McGivern, David R., Fengyu Hu, Daisuke Yamane (206804), David R McGivern, Hu, Fengyu, Hiromichi Dansako (357935), Nobuyuki Kato (235685), Christoph Welsch (22852), Stanley M. Lemon (30543), Daisuke Yamane, Christoph Welsch, Welsch, Christoph, David R. McGivern (415119), Lemon, Stanley M., Kato, Nobuyuki, Fengyu Hu (415120), Dansako, Hiromichi, Stanley M Lemon, Yamane, Daisuke, Nobuyuki Kato, Hiromichi Dansako, Yamane Daisuke, McGivern David R., Welsch Christoph, Hu Fengyu, Dansako Hiromichi, Kato Nobuyuki, Lemon Stanley M.   +27 more
core   +1 more source

High expression of TLR3 in triple-negative breast cancer predicts better prognosis—data from the Fudan University Shanghai Cancer Center cohort and tissue microarrays

BMC Cancer, 2023
Introduction We have previously reported that Toll-like receptor 3 (TLR3) acts as a suppressor gene for breast cancer initiation and progression. In this study, we evaluated the role of TLR3 in breast cancer using our original Fudan University Shanghai ...
Lei Fan, Xin-Yi Sui, Xi Jin, Wen-Juan Zhang, Peng Zhou, Zhi-Ming Shao   +5 more
doaj   +1 more source

Toll-Like Receptors in the Mechanism of Hexabromocyclododecane-Induced Production of Pro-Inflammatory Cytokines. [PDF]

J Appl Toxicol
ABSTRACT Hexabromocyclododecane (HBCD), a brominated flame retardant, has raised increasing health concerns due to its bioaccumulation in human tissues and its ability to induce proinflammatory cytokines. Interleukin‐1β (IL‐1β), interleukin‐6 (IL‐6), and tumor necrosis factor‐α (TNF‐α) are major mediators of inflammation, and their chronic elevation ...
Zhu W, Seaton-Terry A, Townsend B, Hunter Z, Falconer-Turner A, Shahid SR, Whalen M.   +6 more
europepmc   +2 more sources