Results 11 to 20 of about 63,928 (200)

The TLR3 L412F polymorphism prevents TLR3-mediated tumor cell death induction in pediatric sarcomas

Cell Death Discovery, 2023
Toll-like receptor 3 (TLR3) is a pattern recognition receptor mainly known for its role in innate immune response to infection. Indeed, binding of double-stranded RNA (dsRNA) to TLR3 triggers a pro-inflammatory cascade leading to cytokine release and ...
Joseph Bisaccia, Swann Meyer, Adrien Bertrand-Chapel, Quentin Hecquet, Virginie Barbet, Bastien Kaniewski, Sophie Léon, Nicolas Gadot, Isabelle Rochet, Iveta Fajnorova, Pierre Leblond, Martine Cordier-Bussat, Nadège Corradini, Alexandre Vasiljevic, Marc Billaud, Cécile Picard, Laura Broutier, Cindy Gallerne, Aurélie Dutour, Jean-Yves Blay, Marie Castets   +20 more
doaj   +5 more sources

Differential toll-like receptor 3 (TLR3) expression and apoptotic response to TLR3 agonist in human neuroblastoma cells [PDF]

Journal of Biomedical Science, 2011
Background Toll-like receptor-3 (TLR-3) is a critical component of innate immune system against dsRNA viruses and is expressed in the central nervous system.
Du Yung-Ying, Wu Chia-Ling, Huang Chao-Cheng, Chuang Hui-Ching, Chuang Jiin-Haur, Kung Mei-Lang, Chen Chih-Hao, Chen San-Cher, Tai Ming-Hong   +8 more
doaj   +3 more sources

TLR3 impairment in human newborns [PDF]

Journal of Leukocyte Biology, 2013
ABSTRACTNewborns are highly susceptible to viral infections. We hypothesized that this susceptibility could be due to a dysregulated expression of innate virus-sensing receptors, i.e., TLR3, TLR7, TLR8, and TLR9 and the cytosolic receptors retinoic acid-inducible gene I, melanoma differentiation-associated protein 5, protein kinase R, and IFN-γ ...
Lucija, Slavica, Inger, Nordström, Merja Nurkkala, Karlsson, Hadi, Valadi, Marian, Kacerovsky, Bo, Jacobsson, Kristina, Eriksson   +6 more
openaire   +2 more sources

Regulation of TLR3 Activation by S100A9 [PDF]

The Journal of Immunology, 2015
Abstract Recognition of viral dsRNA by endosomal TLR3 activates innate immune response during virus infection. Trafficking of TLR3 to the endolysosomal compartment arising from fusion of late endosome (LE) with lysosome is required for recognition and detection of pathogen associated molecular patterns, which results in activation of the
Su-Yu, Tsai, Jesus A, Segovia, Te-Hung, Chang, Niraj K, Shil, Swechha M, Pokharel, T R, Kannan, Joel B, Baseman, Joan, Defrêne, Nathalie, Pagé, Annabelle, Cesaro, Philippe A, Tessier, Santanu, Bose   +11 more
openaire   +2 more sources

Double-Stranded RNA Attenuates the Barrier Function of Human Pulmonary Artery Endothelial Cells [PDF]

, 2013
Circulating RNA may result from excessive cell damage or acute viral infection and can interact with vascular endothelial cells. Despite the obvious clinical implications associated with the presence of circulating RNA, its pathological effects on ...
A Shibamiya, A Siflinger-Birnboim, AA Birukova, AK Cardozo, Akos Heinemann, AM Lundberg, Andrea Olschewski, Attila G. Végh, B Nilius, BE Dewi, BL Jacobs, C Caspersen, C Kannemeier, C Tiruppathi, Chandran Nagaraj, Csilla Fazakas, D Torres, Diana Zabini, ET Chiang, F Aeffner, G Grynkiewicz, GM Cheng, GU Ahmmed, György Váró, Horst Olschewski, HT Ma, I Khan, I Wilhelm, Imola Wilhelm, István A. Krizbai, J Tissari, JL Harcourt, L Fischer, L Liu, M Auer-Grumbach, M Schroder, MM Szewczyk, N Pirher, NC Stowell, O Dellis, P Kumar, PR Cooper, R Malli, R Malli, R O’Callaghan, R Ross, R Sutliff, Rory Edward Morty, S Akira, S Fischer, S Fischer, S Sarkar, S Zimmer, TG Ksiazek, TM Moore, V Konya, VA Londhe, Viktoria Konya, Y Tsuji, Z Balint, Zoltán Bálint   +60 more
core   +8 more sources

Small molecule SMU-CX24 targeting toll-like receptor 3 counteracts inflammation: A novel approach to atherosclerosis therapy

Acta Pharmaceutica Sinica B, 2022
Toll-like receptor 3 (TLR3), as an important pattern recognition receptor (PRR), dominates the innate and adaptive immunity regulating many acute and chronic inflammatory diseases.
Xiaohong Cen, Baoqu Wang, Yuqing Liang, Yanlin Chen, Yu Xiao, Shaohua Du, Kutty Selva Nandakumar, Hang Yin, Shuwen Liu, Kui Cheng   +9 more
doaj   +1 more source

Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. [PDF]

, 2016
HIV targets the gut mucosa early in infection, causing immune and epithelial barrier dysfunction and disease progression. However, gut mucosal sensing and innate immune signaling through mucosal pattern recognition receptors (PRRs) during HIV infection ...
Bäumler, AJ, Dandekar, S, Gaulke, CA, Glavan, TW, Goulart, LR, Hirao, LA, Jiang, G, Raffatellu, M, Sankaran-Walters, S, Santos Rocha, C   +9 more
core   +8 more sources

A TRIF-Independent Branch of TLR3 Signaling [PDF]

The Journal of Immunology, 2012
Abstract dsRNA is a common pathogen-associated molecular pattern that is recognized by cellular TLR3 and used by virus-infected cells to activate specific transcription factors and trigger induction of antiviral genes. In this article, we report a new branch of TLR3 signaling that does not lead to gene induction but affects many ...
Michifumi, Yamashita, Saurabh, Chattopadhyay, Volker, Fensterl, Ying, Zhang, Ganes C, Sen   +4 more
openaire   +2 more sources

Inflammatory Regulation by TLR3 in Acute Hepatitis [PDF]

The Journal of Immunology, 2009
Abstract TLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrotic cells. Dying cells are a rich source of ligands that can activate TLRs, such as TLR3. TLR3 expressed in the liver is likely to be a mediator of innate activation and inflammation in the liver.
Xiao, Xiaoyan, Zhao, Peng, Rodriguez-Pinto, Daniel, Qi, Dake, Henegariu, Octavian, Alexopoulou, Lena, Flavell, Richard A, Wong, F Susan, Wen, Li   +8 more
openaire   +3 more sources

Heterozygous TLR3 Mutation in Patients with Hantavirus Encephalitis [PDF]

Journal of Clinical Immunology, 2020
AbstractPuumala hantavirus (PUUV) hemorrhagic fever with renal syndrome (HFRS) is common in Northern Europe; this infection is usually self-limited and severe complications are uncommon. PUUV and other hantaviruses, however, can rarely cause encephalitis. The pathogenesis of these rare and severe events is unknown.
Terhi Partanen, Jie Chen, Johanna Lehtonen, Outi Kuismin, Harri Rusanen, Olli Vapalahti, Antti Vaheri, Veli-Jukka Anttila, Michaela Bode, Nina Hautala, Tytti Vuorinen, Virpi Glumoff, Minna Kraatari, Pirjo Åström, Janna Saarela, Heikki Kauma, Lazaro Lorenzo, Jean-Laurent Casanova, Shen-Ying Zhang, Mikko Seppänen, Timo Hautala   +20 more
openaire   +6 more sources