Results 21 to 30 of about 46,970 (197)

Participation of Endosomes in Toll-Like Receptor 3 Transportation Pathway in Murine Astrocytes

Frontiers in Cellular Neuroscience, 2020
TLR3 provides immediate type I IFN response following entry of stimulatory PAMPs into the CNS, as it is in HSV infection. The receptor plays a vital role in astrocytes, contributing to rapid infection sensing and suppression of viral replication ...
Matylda B. Mielcarska, Karolina P. Gregorczyk-Zboroch, Lidia Szulc-Dąbrowska, Magdalena Bossowska-Nowicka, Zbigniew Wyżewski, Joanna Cymerys, Marcin Chodkowski, Paula Kiełbik, Michał M. Godlewski, Małgorzata Gieryńska, Felix N. Toka, Felix N. Toka   +11 more
doaj   +1 more source

Toll-like receptor 3 signaling on macrophages is required for survival following coxsackievirus B4 infection. [PDF]

PLoS ONE, 2009
Toll-like receptor 3 (TLR3) has been proposed to play a central role in the early recognition of viruses by sensing double stranded RNA, a common intermediate of viral replication.
Martin J Richer, Danielle J Lavallée, Iryna Shanina, Marc S Horwitz   +3 more
doaj   +1 more source

Transcriptomic Analysis and C-Terminal Epitope Tagging Reveal Differential Processing and Signaling of Endogenous TLR3 and TLR7

Frontiers in Immunology, 2021
Toll-like receptor (TLR) signaling is critical for defense against pathogenic infection, as well as for modulating tissue development. Activation of different TLRs triggers common inflammatory responses such as cytokine induction.
Chiung-Ya Chen, Yun-Fen Hung, Ching-Yen Tsai, Yi-Chun Shih, Ting-Fang Chou, Ming-Zong Lai, Ting-Fang Wang, Yi-Ping Hsueh   +7 more
doaj   +1 more source

Absence of MyD88 results in enhanced TLR3-dependent phosphorylation of IRF3 and increased IFN-(beta) and RANTES production [PDF]

, 2011
Toll-like receptors are a group of pattern-recognition receptors that play a crucial role in "danger" recognition and induction of the innate immune response against bacterial and viral infections.
Katherine A. Fitzgerald, Moynagh, Paul, Siednienko, Jakub, Moynagh, Paul N., Miggin, Sinead M., Thusitha Gajanayake, Sinéad M. Miggin, Gajanayake, Thusitha, Miggin, Sinéad M, Jakub Siednienko, Paul Moynagh, Miggin, Sinead, Fitzgerald, Katherine A, Fitzgerald, Katherine A.   +13 more
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The effect of using several infectious bronchitis vaccines on the expression of TLR3 in the broiler trachea and kidney [PDF]

Iraqi Journal of Veterinary Sciences
The poultry sector is a relatively recent yet rapidly growing industry, having been established in the early twentieth century, it provides a protein source for the human population.
Ammar M. Al-AAlim, Nashwan Kareem
doaj   +1 more source

LL37 and cationic peptides enhance TLR3 signaling by viral double-stranded RNAs. [PDF]

PLoS ONE, 2011
BACKGROUND:Toll-like Receptor 3 (TLR3) detects viral dsRNA during viral infection. However, most natural viral dsRNAs are poor activators of TLR3 in cell-based systems, leading us to hypothesize that TLR3 needs additional factors to be activated by viral
Yvonne Lai, Sreedevi Adhikarakunnathu, Kanchan Bhardwaj, C T Ranjith-Kumar, Yahong Wen, Jarrat L Jordan, Linda H Wu, Bogdan Dragnea, Lani San Mateo, C Cheng Kao   +9 more
doaj   +1 more source

Agarose gel image depicting TLR3 expression upon TLR3 siRNA knockdown.

, 2021
Lane 1- Control (no siRNA treatment), Lane 2- TLR3 siRNA treatment and Lane 3- non-specific siRNA treatment. (PDF)
Gausal A. Khan (1858336), Madiha Khan (6758228), Saumya Bhagat (11819870), Indranil Biswas (219061), Md Iqbal Alam (11819873)   +4 more
core   +1 more source

Human Endometrial Epithelial Cells Cyclically Express Toll-Like Receptor 3 (TLR3) and Exhibit TLR3-Dependent Responses to dsRNA [PDF]

, 2005
Toll-like receptor 3 (TLR3) responds to dsRNA, a product of most viral life cycles, and initiates production of proinflammatory and antiviral cytokines. The role of TLR3 in human mucosal immunity of the endometrium has not been examined.
Jorgenson, Rebecca L., Misfeldt, Michael L., Lyddon, Terri D., Lesmeister, Margaret J., Young, Steven L.   +4 more
core   +1 more source

TLR3 Expression is a Potential Prognosis Biomarker and Shapes the Immune-Active Tumor Microenvironment in Esophageal Squamous Cell Carcinoma

Journal of Inflammation Research, 2022
Ruibing Su,1,* Lijun Cai,1,* Pan Xiong,1,* Zhiwei Liu,1,* Shaobin Chen,2 Xi Liu,1 Runhua Lin,1 Zhijin Lei,1 Dongping Tian,1 Min Su1 1Institute of Clinical Pathology, Department of Pathology, Shantou University Medical College, Shantou ...
Su R, Cai L, Xiong P, Liu Z, Chen S, Liu X, Lin R, Lei Z, Tian D, Su M   +9 more
doaj  

Inflammatory regulation by TLR3 in acute hepatitis. [PDF]

, 2009
International audienceTLR3 is known to respond to dsRNA from viruses, apoptotic cells, and/or necrotic cells. Dying cells are a rich source of ligands that can activate TLRs, such as TLR3.
Wong, F Susan, Rodriguez-Pinto, Daniel, Qi, Dake, Flavell, Richard A, Flavell, Richard A., Henegariu, Octavian, Alexopoulou, Lena, Wong, Florence Susan, Wen, Li, Zhao, Peng, Xiao, Xiaoyan   +10 more
core   +1 more source