Results 141 to 150 of about 63,490 (224)
Insights Into Macrophage Polarization and M1/M2 Balance in Diabetic Foot Ulcers
Journal of Diabetes, Volume 18, Issue 3, March 2026.This graphical abstract illustrates pharmaceutical agents that modulate M1/M2 macrophage polarization in diabetic foot ulcers (DFUs). M1 macrophages (red) drive inflammation, whereas M2 macrophages (blue) promote tissue repair. In DFUs, persistent M1 predominance contributes to chronic non‐healing. Five key agents targeting this imbalance are depicted:
Jing Zhang +6 more
wiley +1 more source
Cancer Treatment and Research CommunicationsObjectives: Adenoid cystic carcinoma (ACC) of the salivary glands has poor long-term prognosis and a high metastatic rate. Toll-like receptors (TLRs), first-line immune activators, have been associated with both tumor progression and suppression.
Aleksi Rytkönen +6 more
doaj +1 more source
Clinical and Translational Science, Volume 19, Issue 3, March 2026.ABSTRACT Receptor‐interacting serine/threonine‐protein kinase 1 (RIPK1) inhibitors are being investigated for chronic inflammatory diseases such as rheumatoid arthritis, inflammatory bowel disease, and psoriasis. Ocadusertib is a potent and selective allosteric inhibitor of RIPK1 and is currently being studied in clinical trials.
Simon J. Shaw +11 more
wiley +1 more source
How Does Biological Sex Impact Mucosal Bacterial Infection? Mucosal Defenses and Bacterial Detection
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Urinary tract infections possess substantial sex disparities in the incidence, immune response, and progression of infection. Some of these distinctions may be due to sexual dimorphism in mucosal barriers or sex differences in the initial immune response to infection.
Laura Ramirez Finn, Molly A. Ingersoll
wiley +1 more source
Sex Differences in Metabolite–Immune Circuits of Neuroinflammation
Immunological Reviews, Volume 338, Issue 1, March 2026.ABSTRACT Sex is a fundamental yet underexplored determinant of human neuroinflammation. Across autoimmune, neurodegenerative, and post‐infectious neurological syndromes, males and females exhibit consistent differences in disease vulnerability, progression, and immune tone.
Priyanka Saminathan +6 more
wiley +1 more source
Frontiers in Cellular and Infection MicrobiologyIntroductionAlterations in the immune response may influence the development of HTLV-1-associated diseases. TLR3 detects viral nucleic acids, including HTLV-1, and triggers the production of IFN-I and other cytokines. Genetic variations in TLR3 may alter
Fabiane dos Santos Ferreira +18 more
doaj +1 more source
Molecular Microbiology, Volume 125, Issue 3, Page 185-202, March 2026.Human macrophage transcriptomic responses to Mycobacterium avium (Mav), a major cause of nontuberculous lung disease, were compared to Mycobacterium tuberculosis (Mtb). Both infections activated overlapping immune pathways, including cytokine signaling and GPCRs involved in lipid metabolism, while phospholipases were more strongly regulated by Mav and ...
Gül Kilinç +4 more
wiley +1 more source
Cell and Gene Therapy in Equine Ocular Disease
Veterinary Ophthalmology, Volume 29, Issue 2, March 2026.ABSTRACT Equine ocular disease is common and often challenging to treat using traditional methods. This has led to the development of new therapies. Like human medicine, veterinary medicine is adopting cellular and gene therapy as innovative approaches. Equine ocular disease is a particularly promising area for these techniques.
Kimberly A. S. Young +2 more
wiley +1 more source