Results 151 to 160 of about 45,202 (234)

TLR3 Gene [PDF]

, 2020
openaire   +1 more source

Tumor‐Associated Macrophages as Therapeutic Targets: Deciphering Interaction Networks and Advancing Clinical Translation

MedComm, Volume 7, Issue 2, February 2026.
Tumor‐associated macrophages are the most abundant immune cells in the tumor microenvironment, driving malignant progression and treatment resistance. This review summarizes the protumor mechanisms of TAMs (including phagocytosis modulation, metabolic reprogramming, exosomal communication, and immune interactions), evaluates three major strategies ...
Wurihan Bao, Xiaojie Qu, Yiqi Wang, Dan Huang, Huiling Zhang, Mingyuan Dong, Han Sun, Zhaogang Yang, Xuefeng Li   +8 more
wiley   +1 more source

Inflammation and Cancer: Molecular Mechanisms and Therapeutic Targets

MedComm, Volume 7, Issue 2, February 2026.
Chronic inflammation fuels tumorigenesis via “internal drivers” and “external attractions.” Targeting these core mechanisms with combined therapies/novel deliveries enables precise, potent anti‐inflammatory–antitumor treatment. ABSTRACT Inflammation is a core pathological factor regulating tumor initiation, progression, and therapeutic resistance, and ...
Xiaodie Liu, Ziyuan Wang, Huirong Zhu, Yicun Han, Qing Ji   +4 more
wiley   +1 more source

Tumoural activation of TLR3–SLIT2 axis in endothelium drives metastasis

Nature, 2020
B. Tavora, Tobias Mederer, Kai J Wessel, Simon Ruffing, M. Sadjadi, Marc Missmahl, Benjamin N. Ostendorf, Xuhang Liu, Ji-Young Kim, O. Olsen, A. Welm, H. Goodarzi, S. Tavazoie   +12 more
semanticscholar   +1 more source

Progress in RNA‐Targeted Therapeutics for Human Diseases

MedComm, Volume 7, Issue 2, February 2026.
RNA‐targeted therapies are revolutionizing molecular medicine by transitioning from a “protein‐centric” focus to an “RNA‐regulatory network” approach. Leveraging RNA's diverse roles in gene regulation, signaling, and epigenetic modifications, advanced platforms such as ASOs, siRNA, miRNA, mRNA, aptamers, shRNA, and CRISPR/Cas systems are enabling ...
Wangzheqi Zhang, Aimin Jiang, Bin‐Kui Jia, Yuming Jin, Yinghu Chen, Zhaoyu Li, Yan Liao, Haoling Zhang, Zhiheng Lin, Xiao Fang, Linhui Wang   +10 more
wiley   +1 more source

CLEC18A interacts with sulfated glycosaminoglycans and controls clear cell renal cell carcinoma progression

The FEBS Journal, Volume 293, Issue 3, Page 709-728, February 2026.
CLEC18A is a previously poorly characterized C‐type lectin. We mapped the expression of CLEC18A to the proximal tubule of the kidney and found CLEC18A to interact with sulfated glycosaminoglycans on proteoglycans. Furthermore, we found that CLEC18A plays an important role in hindering the progression of clear cell renal cell carcinomas in humans and in
Gustav Jonsson, Maura Hofmann, Stefan Mereiter, Lauren Hartley‐Tassell, Masahiro Onji, Irma Sakic, Tiago Oliveira, David Hoffmann, Maria Novatchkova, Alexander Schleiffer, Josef M. Penninger   +10 more
wiley   +1 more source

Zika Virus Depletes Neural Progenitors in Human Cerebral Organoids through Activation of the Innate Immune Receptor TLR3.

Cell Stem Cell, 2016
Jason W. Dang, S. Tiwari, Gianluigi Lichinchi, Yue Qin, Veena S Patil, A. Eroshkin, T. Rana   +6 more
semanticscholar   +1 more source

TLR3 wt Allele [PDF]

, 2020
openaire   +1 more source

Tumor Exosomal RNAs Promote Lung Pre-metastatic Niche Formation by Activating Alveolar Epithelial TLR3 to Recruit Neutrophils.

Cancer Cell, 2016
Yanfang Liu, Yan Gu, Yanmei Han, Qian Zhang, Zhengping Jiang, Xiang Zhang, Bo Huang, Xiaoqing Xu, Jianming Zheng, Xuetao Cao   +9 more
semanticscholar   +1 more source

TLR3: rising above redundancy [PDF]

Nature Reviews Immunology, 2007
openaire   +1 more source