Results 151 to 160 of about 262,724 (386)
Emodin targets BCL‐10 to modulate the BCL‐10/MALT1 complex, thereby suppressing NF‐κB activation and significantly exerting multiorgan protective effects in sepsis. Abstract Sepsis is a life‐threatening condition caused by dysregulated host responses to infection, characterized by excessive inflammation and abnormal coagulation.
Xiaolong Xu+16 more
wiley +1 more source
Background: Lifestyle modification through dietary interventions and exercise training is still one of the most effective ways to treat non-alcoholic fatty liver disease.
Majid Farah Nia +3 more
doaj
Gut immune dysfunction through impaired innate pattern recognition receptor expression and gut microbiota dysbiosis in chronic SIV infection. [PDF]
HIV targets the gut mucosa early in infection, causing immune and epithelial barrier dysfunction and disease progression. However, gut mucosal sensing and innate immune signaling through mucosal pattern recognition receptors (PRRs) during HIV infection ...
Bäumler, AJ+9 more
core +2 more sources
Despite the wealth of genomic and transcriptomic data in Parkinson’s disease (PD), the initial molecular events are unknown. Using LD score regression analysis, we show significant enrichment in PD heritability within regulatory sites for LPS-activated ...
Craig D. Hughes+11 more
semanticscholar +1 more source
This work designs an in situ proliferating peptide nanoparticle as a flexible resolution that modulates the neuro‐glia unit to enable enhanced multi‐target combinational therapy for secondary brain damage following subarachnoid hemorrhage. Abstract Subarachnoid hemorrhage (SAH), a lethal stroke subtype, involves complex pathological cascades triggered ...
Yibin Zhang+8 more
wiley +1 more source
Dendritic cell (DC)-based vaccines are recognized as a promising immunotherapeutic strategy against cancer. Various adjuvants are often incorporated to enhance the modest immunogenicity of DC vaccines.
Young Seob Kim+14 more
doaj +1 more source
NQO1 targeting prodrug triggers innate sensing to overcome checkpoint blockade resistance [PDF]
Lack of proper innate sensing inside tumor microenvironment (TME) limits T cell-targeted immunotherapy. NAD(P)H:quinone oxidoreductase 1 (NQO1) is highly enriched in multiple tumor types and has emerged as a promising target for direct tumor-killing ...
Boothman, David A.+10 more
core +1 more source
Compared with EBV‐negative epithelial cancer cells, EBV‐associated epithelial cancer cells exhibit enhanced secretion of chemokines, including CXCL10 and CCL5, to attract neutrophils. Via the CXCL10‐CXCR3 axis‐mediated positive feedback loop, neutrophils within EBV‐associated epithelial cancer cells are induced to form abundant NETs, which facilitate ...
Dijun Ouyang+24 more
wiley +1 more source
Astragalus polysaccharides (APS), which is widely used as a remedy to promote immunity of breast cancer patients, can enhance immune responses and exert anti-tumor effects.
Lijing Zhou+6 more
semanticscholar +1 more source
Research Progress on Biomaterials with Immunomodulatory Effects in Bone Regeneration
This review highlights recent advanced in immunomodulatory biomaterials for bone repair, focusing on design strategies, immune interactions, and clinical potential. Abstract The immune system plays a pivotal role in bone regeneration, and biomaterials engineered to modulate immune responses present a promising strategy for the treatment of extensive ...
Jianan Li+11 more
wiley +1 more source