Results 151 to 160 of about 175,490 (344)

TLR4 links innate immunity and fatty acid-induced insulin resistance.

Journal of Clinical Investigation, 2006
Hang Shi, M. Kokoeva, K. Inouye, Iphigenia Tzameli, Huali Yin, J. Flier   +5 more
semanticscholar   +1 more source

Activation of USP30 Disrupts Endothelial Cell Function and Aggravates Acute Lung Injury Through Regulating the S‐Adenosylmethionine Cycle

Advanced Science, EarlyView.
USP30 deubiquitinates and stabilizes MAT2A, thereby regulating DNA methylation and miRNA expression, which ultimately leads to disruption of lung endothelial barrier and inflammation. Abstract Microvascular dysfunction is a key contributor to the development of acute inflammatory diseases, characterized by heightened vascular hyperpermeability and ...
Baoyinna Baoyinna, Jinshan He, Jiaxing Miao, Nargis Shaheen, Boyu Xia, Cankun Wang, Qin Ma, Matthew C Bernier, Bryan A Whitson, Nuo Sun, Jing Zhao, Yutong Zhao   +11 more
wiley   +1 more source

Ontogeny of Toll-Like Receptors Tlr2 and Tlr4 in Mice [PDF]

, 2001
Kirsi Harju, Virpi Glumoff, Mikko Hallman   +2 more
openalex   +1 more source

Palmitate is not a TLR4 agonist [PDF]

Nature Reviews Endocrinology, 2018
openaire   +2 more sources

Dual‐Pedicle Tissue‐Engineered Trachea Promotes Biomimetic Cartilaginous Framework, Vascularization, and Epithelial Lining for Long‐Segment Tracheal Reconstruction

Advanced Science, EarlyView.
Overcoming the limitations of conventional grafts, a biomimetic trachea with two independent vascular pedicles enables rapid integration and sustained patency. This approach markedly improves survival rates, restores the epithelial barrier, and promotes regenerative pathways, presenting a transformative paradigm for clinical application.
Ziming Wang, Yuming Wang, Zihao Chen, Erji Gao, Liang Guo, Juanjuan Li, Siqiang Zheng, Jiaoyu Yi, Zhe‐Sheng Chen, Bo Tao   +9 more
wiley   +1 more source

LBP, CD14, TLR4 and the murine innate immune response to a peritoneal Salmonella infection [PDF]

, 2001
Martin Bernheiden, Jan-Michael Heinrich, Gabriela Minigo, Christine Schütt, Felix Stelter, Mason W. Freeman, Douglas T. Golenbock, Robert Smail Jack   +7 more
openalex   +1 more source

Nanozymes for Non‐Neoplastic Diseases: Catalytic Therapy Redefined

Aggregate, EarlyView.
Non‐neoplastic diseases pose a significant health burden. Nanozymes, enzyme‐like nanomaterials, offer promising strategies for regulating oxidative stress and inflammation. This review explores their development, structure–function relationships, and therapeutic potential, with a focus on precision medicine through targeted delivery and multimodal ...
Ling Mei, Xikai Wang, Zhuang Hu, Jierui Yan, Xiaobo Wang, Haoran Wang, Ya Hou, Pengfei Zhang, Qihang Ding   +8 more
wiley   +1 more source

Decoding a Gut Commensal Signal: Structural and Immunological Profiling of Segatella Copri Lipopolysaccharide

Angewandte Chemie, EarlyView.
The lipopolysaccharide (LPS) of Segatella copri is a structurally unique, immunomodulatory glycoconjugate. Combining mass spectrometry (MS), nuclear magnetic resonance (NMR), and cytometry by time‐of‐flight (CyTOF), we uncover a rough‐type LPS with reduced TLR4 agonism and selective monocyte effects, further highlighting the key role of LPS chemistry ...
Luca De Simone Carone, Giusi Barra, Roberta Cirella, Marcello Ziaco, Marcello Mercogliano, Francesca Olmeo, Emanuela Andretta, Valentina Mazziotti, Carmela Fusco, Giuliana D'Ippolito, Katarzyna Anna Duda, Freda M. Farquharson, Petra Louis, Angelo Fontana, Alba Silipo, Antonio Molinaro, Fabrizio Chiodo, Flaviana Di Lorenzo   +17 more
wiley   +2 more sources

Determination of the TLR4 Genotype Using Allele-Specific PCR [PDF]

, 2001
Eva Lorenz, Kathy L. Frees, David A. Schwartz   +2 more
openalex   +1 more source

Differential roles of TLR2 and TLR4 in recognition of gram-negative and gram-positive bacterial cell wall components.

Immunity, 1999
O. Takeuchi, K. Hoshino, T. Kawai, H. Sanjo, H. Takada, T. Ogawa, K. Takeda, S. Akira   +7 more
semanticscholar   +1 more source