Results 251 to 260 of about 170,484 (302)

Toll like receptor 4 (TLR4) in neuroinflammation: From acute hemorrhagic stroke to chronic neurodegeneration. [PDF]

J Cereb Blood Flow Metab
Choudhary HH, Yoshida J, Islam R, Wang Z, Hanafy KA.   +4 more
europepmc   +1 more source

S100A9 promotes pulmonary arterial hypertension by regulating mitochondria–endoplasmic reticulum interaction‐mediated inflammatory injury of endothelial cells

Interdisciplinary Medicine, EarlyView.
Macrophage‐derived S100 calcium‐binding protein A9 (S100A9) promotes the pathological progression of pulmonary arterial hypertension (PAH). S100A9 upregulates the interaction between signal‐transducing adaptor protein 2 and leucine‐rich repeat kinase 2, thereby regulating mitochondria–endoplasmic reticulum (ER) contact.
Chen Gong, Long Chen, Yiting Zhao, Xiaohe Wang, Qiang Yuan, Xiaofeng Fang, Liuyi Li, Yinbo Xu, Shumei Jiang, Guangwen Xu, Ke Meng, Delong Wang, Kangli Cao, Jianlong Sheng, Liling Guo, Shichun Shen   +15 more
wiley   +1 more source

Mixed lineage kinase 3 mediates SARS‐CoV‐2‐induced kidney injury via the Hsp70‐IL‐17A axis

Interdisciplinary Medicine, EarlyView.
Kidney samples from patients infected with severe acute respiratory syndrome coronavirus 2 (SARS‑CoV‑2) showed upregulated expression and activity of Mixed Lineage Kinase (MLK3). Based on the mechanistic studies, we identified MLK3 as a critical player in promoting SARS‐CoV‐2‐induced kidney injury.
Sandeep Kumar, Sunil Kumar Singh, Piush Srivastava, Sowdhamini Mahendiran, Rakesh Sathish Nair, Harsh Vyas, Saket Jha, Niraj Nag, Navin Viswakarma, Hitesh Kapoor, Swathi Suresh, Periannan Sethupathi, Sang‐Ging Ong, Jerrold S. Levine, Suman Setty, Mathayan Manikannan, Bellur S. Prabhakar, Basabi Rana, Ajay Rana   +18 more
wiley   +1 more source

Integrative Bioinformatics Prioritizes the <i>TLR4</i> Axis and Candidate Non-Starch Polysaccharides in Hyperuricemia-Associated Inflammation. [PDF]

Biology (Basel)
You P, Chen A, Feng Q, Hou J, Zheng J, Chen H.   +5 more
europepmc   +1 more source

Risk of Erythritol-Associated Ischemic Stroke: Integrated Genetic, Transcriptomic, and Machine Learning Evidence. [PDF]

Int J Mol Sci
Zhong A, Yu F, Xia C, Ma X, Zhu Q, Du P, Wang R, Jin S.   +7 more
europepmc   +1 more source

In silico framework for designing and validating a multi-stage subunit vaccine against Tuberculosis using reverse vaccinology approach. [PDF]

PLoS One
Liaqat A, Dastgir K, Sajjad M, Rehman HM, Akhtar MW.   +4 more
europepmc   +1 more source

PPARγ-Dependent Pioglitazone Treatment Suppresses Neuroinflammation and Improves Cognition in Sepsis-Associated Encephalopathy in Mice. [PDF]

CNS Neurosci Ther
Zhang J, Wang P, Li N, Gao Y.
europepmc   +1 more source

Oncolytic virus OHSV2 induces pyroptosis in bladder cancer cells via the TLR4/NLRP3/Caspase-1/GSDMD pathway. [PDF]

Mol Biomed
Xu J, Xiong Y, Liu C, Sun J, An Y, Xia Z, Liu B, Hu J, Xia Q, Wang S.   +9 more
europepmc   +1 more source

Correction to "S100A9 Aggravates Cardiac Fibrosis by TLR4/PGC-1α Mediated Macrophage-Myofibroblast Crosstalk". [PDF]

J Extracell Vesicles
europepmc   +1 more source