Results 261 to 270 of about 170,484 (302)

Cigarette Smoke Upregulates TLR4 Expression and Enhances TLR4 Mediated Responses

, 2006
A key component of the innate defence mecbanisms against infections is represented by the tolllike receptor (TLR) family. We explored the role played by TLR4 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We first assessed TLR4 expression by immunohystochemistry in surgical specimens from current and former smoker COPDs, from ...
PACE E, FERRARO M, MINERVINI MI, CHIAPPARA G, SIENA L, PIPITONE L, MELIS MR, MONTALBANO AM, BONSIGNORE MR, BELLIA V, BONSIGNORE G, GJOMARKAJ M   +11 more
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Involvement of ILR4α and TLR4 in miscarriages

Journal of Reproductive Immunology, 2019
The purpose of this study was to analyze the involvement of signaling via Interleukin-4-Receptor α (IL4Rα) and Toll like receptor (TLR) 4 at the fetomaternal interface in the process of early pregnancy.Placenta specimens of 46 patients in early pregnancy were analyzed (normal pregnancy (n = 15), spontaneous (n = 15) and habitual abortion (n = 16 ...
Theresa Maria Kolben, Elisabeth Rogatsch, Anna Hester, Christina Kuhn, Elisa Schmoeckel, Bastian Czogalla, Sven Mahner, Udo Jeschke, Thomas Kolben   +8 more
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TLR4 polymorphisms and disease susceptibility

Inflammation Research, 2012
Toll-like receptors (TLRs) play a central role in the regulation of the host immune system. Each TLR recognizes specific pathogen-associated molecular patterns (PAMPs). TLR4 is one of the well characterized pathogen recognition receptors (PRRs) that recognizes the lipopolysaccharide (LPS) of Gram-negative bacteria, some conserved structures from fungal
Mamoona, Noreen, Muhammad Ali A, Shah, Sheeba Murad, Mall, Shazia, Choudhary, Tahir, Hussain, Iltaf, Ahmed, Syed Fazal, Jalil, Muhammad Imran, Raza   +7 more
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TLR4 agonists as immunomodulatory agents

Journal of Endotoxin Research, 2006
Monophosphoryl lipid A (MPL ® ) is a potent vaccine adjuvant derived from Salmonella minnesota that was recently licensed in Europe as a component of an improved vaccine for hepatitis B (Fendrix ® ). MPL, like lipopolysaccharide from which it is derived,
Mark R, Alderson, Patrick, McGowan, Jory R, Baldridge, Peter, Probst   +3 more
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Regulators of TLR4 Signaling by Endotoxins

2010
The stimulation of TLR4 by LPS activates two distinct signaling pathways leading to the expression of diverse inflammatory genes. Intensive studies over the past decade have revealed the components involved in these signaling pathways, however, more recently the focus has shifted somewhat towards the components that regulate these pathways.
Anne F, McGettrick, Luke A J, O'Neill
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TLR4 and LPS hyporesponsiveness in humans

International Journal of Hygiene and Environmental Health, 2002
Asthma is a complex genetic disorder that is caused by a number of unique gene-gene and gene-environment interactions. The search for asthma susceptibility genes has been complicated by the broad clinical phenotype of asthma, the polygenic inheritance pattern of this disease, and the substantial role of environmental exposures in the development and ...
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Move Over, TLR4

Science, 2013
Cytoplasmic lipopolysaccharide from Gram-negative bacteria can activate the innate immune system directly.
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TLR4 as the Mammalian Endotoxin Sensor

2002
For more than a century, the ability to sense endotoxin (later known also as lipopolysaccharide; LPS) stood as the archetypal innate immune response: even before the phrase 'innate immunity' became popular. Yet the mechanism by which LPS initiated a signal remained unknown.
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?????????????????????? 896A/G ???????? TLR4, ?? ???? 1196C/T ???????? TLR4 ???? 2258G/A ???????? TLR2 ???????????????? ???????????? ???? ?????????????????????? ?????????????? ???????????????????? ?????????????????? ?? ??????????

2017
1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
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Intracellular TLR4 Signaling

2020
Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
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