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LPS/TLR4 signal transduction pathway
Cytokine, 2008The stimulation of Toll-like receptor 4 (TLR4) by lipopolysaccharide (LPS) induces the release of critical proinflammatory cytokines that are necessary to activate potent immune responses. LPS/TLR4 signaling has been intensively studied in the past few years.
Yong-Chen, Lu +2 more
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Trends in Microbiology, 2002
The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
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The recognition of microbial pathogens based on their molecular patterns is essential for host defense. Recently, Toll-like receptors have been shown not only to recognize viruses as well as bacteria and fungi, but also to trigger an efficient immune response.
Susan R Ross, John C Rassa
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2009
The term acute bronchiolitis is used to describe the clinical syndrome that consists of respiratory distress and wheezing from a viral lower respiratory tract infection in children until the age of two years. RSV is the most common pathogen and it affects nearly 100% of children in the first two years of life.
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The term acute bronchiolitis is used to describe the clinical syndrome that consists of respiratory distress and wheezing from a viral lower respiratory tract infection in children until the age of two years. RSV is the most common pathogen and it affects nearly 100% of children in the first two years of life.
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TLR4 agonists as immunomodulatory agents
Journal of Endotoxin Research, 2006Monophosphoryl lipid A (MPL®) is a potent vaccine adjuvant derived from Salmonella minnesota that was recently licensed in Europe as a component of an improved vaccine for hepatitis B (Fendrix®). MPL, like lipopolysaccharide from which it is derived, signals via the TLR4/MD-2 complex.
Mark R, Alderson +3 more
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2020
Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
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Intracellular part of TLR4 signaling starts on the inner side of the cytoplasm and consists of two branches, namely, TLR4/TRIF/IRF3 and TLR4/MyD88/NF-κB. Through complex interactions including phosphorylation and ubiquitination, they lead to the activation of various transcription factors and are intrinsically regulated.
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2017
1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
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1196C/T ???????? TLR4 ?????????? ?????????? ?????????????? ?????????????????????? ???????????????????? (????) ???? ?????????????????? ?? ?????????????? ????????????????. ?? ???????????????????? ?????????????? ?????????????????????????? ?????????????????? ?? ?????????????? ?????????? TLR2 ?? TLR4 ??????????????????????, ?????? ?????????????????? ????????
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Inflamed by TLR4 internalization
Science, 2020Immunology The pattern recognition receptor Toll-like receptor 4 (TLR4) stimulates the production of proinflammatory cytokines when activated on the cell surface, but endocytosed TLR4 signals through different effectors to drive the production of an antiviral cytokine called interferon-β. Metwally et al.
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Cigarette Smoke Upregulates TLR4 Expression and Enhances TLR4 Mediated Responses
2006A key component of the innate defence mecbanisms against infections is represented by the tolllike receptor (TLR) family. We explored the role played by TLR4 in the pathogenesis of chronic obstructive pulmonary disease (COPD). We first assessed TLR4 expression by immunohystochemistry in surgical specimens from current and former smoker COPDs, from ...
PACE E +11 more
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TLR4 and LPS hyporesponsiveness in humans
International Journal of Hygiene and Environmental Health, 2002Asthma is a complex genetic disorder that is caused by a number of unique gene-gene and gene-environment interactions. The search for asthma susceptibility genes has been complicated by the broad clinical phenotype of asthma, the polygenic inheritance pattern of this disease, and the substantial role of environmental exposures in the development and ...
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2014
???????????????????? ?????????????????????? ???????????????????????????????? ?????????????????????? ?????????????????? Arg753Gln ???????? TLR2 ???? Asp299Gly, Thr399Ile ???????? TLR4 ?????????? ????????, ???? ???????????????????? ?? ?????????????????????? ??????????????, ?? ?????????? ??????????????? ?????????????????????????? ???? ?????????????????? ??
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???????????????????? ?????????????????????? ???????????????????????????????? ?????????????????????? ?????????????????? Arg753Gln ???????? TLR2 ???? Asp299Gly, Thr399Ile ???????? TLR4 ?????????? ????????, ???? ???????????????????? ?? ?????????????????????? ??????????????, ?? ?????????? ??????????????? ?????????????????????????? ???? ?????????????????? ??
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