Results 271 to 280 of about 175,490 (344)

Interstitial Cystitis/Bladder Pain Syndrome Patient Phenotyping

Neurourology and Urodynamics, EarlyView.
ABSTRACT Aims In April of 2025, the Wake Forest Institute for Regenerative Medicine hosted a Global Consensus meeting on IC/BPS in Winston‐Salem, NC. The goal of this meeting was to establish global consensus regarding diagnostic criteria, phenotyping, treatment outcome assessment, and etiopathology in interstitial cystitis/bladder pain syndrome (IC ...
Dylan T. Wolff, Stephen Tranchina, Andrew Schrepf, R. Christopher Doiron, Toby C. Chai, Stephen J. Walker   +5 more
wiley   +1 more source

Necrotizing Enterocolitis: A Comprehensive Review on Toll-like Receptor 4-Mediated Pathophysiology, Clinical, and Therapeutic Insights. [PDF]

Biomedicines
Ishiyama A, Jang HS, Dintaman JM, Duess JW, Tragesser C, Sodhi CP.   +5 more
europepmc   +1 more source

Faculty Opinions recommendation of LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF.

, 2003
David M. Underhill
openalex   +2 more sources

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

[Cinnamic acid ameliorates doxorubicin-induced myocardial injury in mice by attenuating cardiomyocyte ferroptosis <i>via</i> inhibiting TLR4]. [PDF]

Nan Fang Yi Ke Da Xue Xue Bao
Yun Q, DU R, He Y, Zhang Y, Wang J, Ye H, Li Z, Gao Q.   +7 more
europepmc   +1 more source

Cytoplasmic LPS Activates Caspase-11: Implications in TLR4-Independent Endotoxic Shock

Science, 2013
Jon A. Hagar, D. Powell, Y. Aachoui, R. Ernst, Edward A. Miao   +4 more
semanticscholar   +1 more source

Mining Alzheimer's Interactomes, Macromolecular Complexes and Pathways for Drug Discovery

PROTEOMICS, EarlyView.
ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder that leads to dementia. Many cases are diagnosed annually and there is no currently available cure. Understanding the underlying disease biology of AD through the study of molecular networks, particularly by mapping clinical variants to tissue‐specific interactomes and ...
Kalpana Panneerselvam, Krishna Kumar Tiwari, Luana Licata, Simona Panni, Sylvie Ricard‐Blum, Sucharitha Balu, Susie Huget, Juan Jose Medina Reyes, Eliot Ragueneau, Livia Perfetto, Birgit Meldal, Sandra Orchard, Henning Hermjakob   +12 more
wiley   +1 more source

Xianglian Anchang Decoction Mitigates Ulcerative Colitis via Inhibition of TLR-4-Mediated Pyroptosis. [PDF]

J Inflamm Res
Zhang S, Wang Y, Ren X, Chen H, Gao T, Liu Y, Lu L, Ma J, Bai H, Wang Y.   +9 more
europepmc   +1 more source

Mastitis Increases Mammary mRNA Abundance of β-Defensin 5, Toll-Like-Receptor 2 (TLR2), and TLR4 but Not TLR9 in Cattle

, 2004
Tom Goldammer, Holm Zerbe, Adrian Molenaar, H. J. Schuberth, Ronald M. Brunner, S.R. Kata, Hans‐Martin Seyfert   +6 more
openalex   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source