Results 271 to 280 of about 237,895 (332)

Investigation of the Mechanism of Cinnamaldehyde in Irritable Bowel Syndrome Based via Network Pharmacology, Molecular Docking, and Animal Experiments

Pediatric Discovery, EarlyView.
Through network pharmacology and molecular docking, it has been discovered that CA can target MAOB, among other proteins, to exert a therapeutic effect in IBS. In vivo, CA lowered visceral hypersensitivity, anxiety and depression‐like behaviors, and fecal water content, highlighting its therapeutic potential for IBS via anti‐inflammatory pathways ...
Qingyang Yu, Boqing Xu, Chunfang Dai, Yayan Pang, Zhifang Dong   +4 more
wiley   +1 more source

Effects of combined prenatal exposure to air pollution and maternal stress on immune and dopaminergic gene expression in the gut-brain axis. [PDF]

Brain Behav Immun Health
Martin EM, Morales MJ, Li NY, Stoehr MC, Kern MJ, Winters MF, Smith CJ.   +6 more
europepmc   +1 more source

Protective Effect of Benzoquinone Isolated from the Roots of Averrhoa carambola L. on Streptozotocin-Induced Diabetic Mice by Inhibiting the TLR4/NF-κB Signaling Pathway

, 2020
Qin L, Xiang Zhang, Xin Zhou, Xiaoxia Wu, Xiaoyi Huang, Min Chen, Yi-Hang Wu, Lu Shen, Hailin Zhang, Xin-ying Xu, Xiao‐Hong Wei, Sijie Zhang, Riming Huang   +12 more
openalex   +1 more source

Nigericin‐Triggered Phosphodynamics in Inflammasome Formation and Pyroptosis

PROTEOMICS, EarlyView.
ABSTRACT Innate immune signaling relies heavily on phosphorylation cascades to mount effective immune responses. Although traditional innate immune signaling cascades following TLR4 stimulation have been investigated through a temporally quantitative phosphoproteomic lens, far fewer studies have applied these methods to distinct signaling following the
Vanya Bhushan, Clinton J. Bradfield, Sandhini Saha, Sung Hwan Yoon, Iain D. C. Fraser, Aleksandra Nita‐Lazar   +5 more
wiley   +1 more source

The immune receptors TLR4 and SLAMF1 regulate TNF release by human metapneumovirus in human macrophages. [PDF]

Front Immunol
Sæterhaug Bye K, Rian K, Ryan L, Espevik T, Anthonsen MW, Yurchenko M.   +5 more
europepmc   +1 more source

A new perspective on cancer treatment: the interaction and application prospect between ICIs and radiotherapy

Precision Radiation Oncology, EarlyView.
The combination of immune checkpoint inhibitors (ICIs) and radiotherapy synergistically enhances efficacy through an “antigen release‐immune activation” closed‐loop mechanism, significantly improving outcomes in solid tumors (e.g., lung cancer, melanoma).
Guiling Song, Lei Wang, Guopeng Zhao, Song Tan, Xin Liu, Xinghua Li   +5 more
wiley   +1 more source

Advanced Glycation End Products Promote PGE₂ Production in Ca9-22 Cells via RAGE/TLR4-Mediated PKC-NF-κB Pathway. [PDF]

Cells
Ono M, Tanabe N, Ichikawa R, Tomita K, Manaka S, Seki H, Imai Y, Aoki M, Masai Y, Takayama T, Suzuki N, Sato S.   +11 more
europepmc   +1 more source

Minocycline inhibits rosacea-like inflammation through the TLR4-mediated NF-κB signaling pathway in vivo and in vitro

Piyan Hua, Ying Tu, Zhenghui Yang, Yunting He, Li He, Qiuyan Yao, Hua Gu   +6 more
openalex   +1 more source

From Membrane Composition to Antimicrobial Strategies: Experimental and Computational Approaches to AMP Design and Selectivity

Small, EarlyView.
Antimicrobial peptides (AMPs) are promising candidates for next‐generation antibiotics, acting through mechanisms such as membrane disruption and intracellular targeting. This review examines how variations in bacterial membrane composition critically influence AMP activity.
Paolo Rossetti, Marius F.W. Trollmann, Christina Wichmann, Thomas Gutsmann, Christian Eggeling, Rainer A. Böckmann   +5 more
wiley   +1 more source

Computational development of multi-epitope vaccine to induce adaptive immunity against multi-drug resistant Prevotella intermedia. [PDF]

BMC Infect Dis
Kanwal A, Shah M, Khan MU, Latif M, Anum H, Younas S, Aljasham AT, Ojha SC.   +7 more
europepmc   +1 more source