Results 111 to 120 of about 148,110 (341)

Toll-Like Receptors and Diabetic Nephropathy: A Review of Recent Advances

Turkish Journal of Immunology
Diabetic nephropathy (DN) is one of the most common kidney diseases, but its exact pathophysiology remains unknown. Toll-like receptors (TLRs) are innate immune receptors that recognize pathogen- and danger-associated molecular patterns, which can result
Mohammad Sadra Gholami Chahkand, Yasaman Tavakoli, Ava Aghakhani, Monireh Askarzadeh, Hosein Azimi, Nogol Ghalamkarpour, Alaleh Alizadeh, Iman Archin, Sajad Kermani, Akram Ansari, Mohadeseh Poudineh, Zahra Mali, Elaheh Foroughi, Gisou Erabi, Seyed Amirhossein Mazhari, Mohammad Sadegh Fallahi, Niloofar Deravi, Parisa Alsadat Dadkhah   +17 more
doaj   +1 more source

Engineering Microbial Particles for Next‐Generation Biomedical Platforms

Advanced Science, EarlyView.
Microbe‐derived particles (MDPs), which include extracellular vesicles, outer membrane vesicles, inclusion bodies, polysaccharide particles, and virus‐like particles, represent a rapidly expanding category of bioinspired nanomaterials. With their natural origin, intrinsic biocompatibility, and highly programmable functionality, MDPs serve as a ...
Yuting Li, Yunjie Lu, Ziyan Huang, Jianjiang Chen, Yanbin Liu, Lei Qin, Chao Wang, Yumin Wu   +7 more
wiley   +1 more source

Synergistic interactions between NOD receptors and TLRs: Mechanisms and clinical implications

Journal of Leukocyte Biology, 2018
Interactions between pattern recognition receptors (PRRs) shape innate immune responses to particular classes of pathogens. Here, we review interactions between TLRs and nucleotide‐binding oligomerization domain 1 and 2 (NOD1 and NOD2) receptors, two ...
M. Pashenkov, N. Murugina, A. Budikhina, B. Pinegin   +3 more
semanticscholar   +1 more source

Expression of toll-like receptors (tlrs) in the equine peripheral blood mononuclear cells (pbmcs) during the early pregnancy and estrous cycle [PDF]

Eurasian Journal of Veterinary Sciences
Aim: Practical, reliable and economical pregnancy diagnosis method for as early as possible time of pregnancy in mares is still requirement. Immune tolerance against allogenic fetus is critically important during the early pregnancy.
Ercan Kurar, Mehmet Osman Atli, Aydin Guzeloglu, Seyit Ali Kayis, Ahmet Semacan   +4 more
doaj  

Signatures of balancing selection in toll-like receptor (TLRs) genes – novel insights from a free-living rodent

Scientific Reports, 2018
Selective pressure from pathogens is considered a key selective force driving the evolution of components of the immune system. Since single components of the immune system may interact with many pathogens, and single pathogens may be recognized by ...
A. Kloch, Marius A. Wenzel, D. Laetsch, Olek Michalski, A. Bajer, J. Behnke, R. Welc-Falęciak, S. Piertney   +7 more
semanticscholar   +1 more source

Senescent Cell Derived Artificial Vesicle‐Based Senolytic Sonovaccine Platform with Augmented Lymph Node Delivery and Antigen Cross‐Presentation Efficacy

Advanced Science, EarlyView.
A senolytic sonovaccine platform (SenoVac) is developed, in which senescent cell‐derived vesicles serve as broad senescent cell antigen reservior. The “2‐step” click chemistry strategy for effective lymph node delivery, and ultrasound‐triggered endosomal escape to boost cross‐presentation, ensures efficient senescent cell clearance and disease ...
Liang Zhang, Yubo Lai, Jia Wang, Lingling Liu, Jieyuan An, Mi Qu, Yuan Liang, Bijun Tan, Guodong Yang, Xuekang Yang, Lijun Yuan   +10 more
wiley   +1 more source

Toll-like receptors in esophageal cancer

Frontiers in Immunology, 2014
Esophageal squamous cell carcinoma and esophageal adenocarcinoma are cancers of high mortality. Esophageal adenocarcinoma develops through Barrett’s esophagus and columnar dysplasia, preceded by gastroesophageal reflux disease.
Joonas H Kauppila, Joonas H Kauppila, Joonas H Kauppila, Joonas H Kauppila, Katri S Selander, Katri S Selander   +5 more
doaj   +1 more source

Viral Modulation of TLRs and Cytokines and the Related Immunotherapies for HPV-Associated Cancers

Journal of Immunological Research, 2018
The modulation of the host innate immune system is a well-established carcinogenesis feature of several tumors, including human papillomavirus- (HPV-) related cancers.
Marconi Rego Barros, T. H. A. de Oliveira, C. M. L. de Melo, A. Venuti, A. C. de Freitas   +4 more
semanticscholar   +1 more source

NMI Regulates Adipose Adaptive Thermogenesis Through TLR4/IRF3 Signaling to Promote Obesity

Advanced Science, EarlyView.
Adipose tissue‐derived NMI is secreted under metabolic stress and suppresses adaptive thermogenesis through TLR4/IRF3 signaling, repressing the PPARα/PGC‐1α/UCP1 thermogenic transcriptional program. Genetic ablation or anti ‐ NMI monoclonal antibody treatment enhances energy expenditure, protects against DIO, and ameliorates adipose tissue inflammation,
Ting‐Ting Li, Xin‐Yuan Zhao, Min Zhang, Zhuang‐Feng Weng, Xiao‐Ran Guo, Ying‐Fang Liu, Qiao‐Ping Wang, Huan‐Huan Liang   +7 more
wiley   +1 more source

Outside Influence: TLRs Direct Hematopoietic Cell Fates [PDF]

, 2006
Toll-like receptors (TLRs) modulate immune responses indirectly by promoting the efficacy of antigen presentation. In this issue of Immunity, Nagai et al.
Kelsoe, Garnett, Holl, T. Matt
core   +1 more source