Results 141 to 150 of about 148,110 (341)

Peran Toll Like Receptors (TLRs) pada Innate Immunity [PDF]

, 2015
TLRs is a homologous protein located at APC membrane cell work as a functional receptor to activate leucocyte lead to induce innate immune response against pathogenic agent.
Nuzulul Hikmah, I Dewa Ayu Ratna Dewanti
core  

P145 La trimethylamine, métabolite du microbiote intestinal, inhibe la voie inflammatoire des Toll-Like Receptor (TLRs) via une inhibition directe d’une enzyme clé de la transduction du signal [PDF]

, 2015
Introduction L’obésité est associée à une inflammation chronique de faible intensité caractérisée par une augmentation des niveaux circulants de cytokines pro-inflammatoires comme l’IL-6.
Gerard, C., Gooderham, N., Boulange, C., Fearnside, J., Nicholson, J.K., Chilloux, J., Calderari, S., Gaugier, D., Glen, R., Barton, R., Scott, J., Rothwell, A., Gauguier, D., Hoyles, L., Dumas, M.-E., Fuchs, J., Patel, S.   +16 more
core   +1 more source

Psychological Stress Associated Bile Acid Reprogramming Promotes Hepatocellular Carcinoma Progression

Advanced Science, EarlyView.
Depression is increasingly recognized as a risk factor for chronic diseases, yet its biological impact on cancer remains unclear. Using data from more than 490 000 participants across three international cohorts, we show that depression significantly increases the risk of liver cancer.
Ruijiang Zeng, Mengmeng Wang, Kang Wang, Zhuo Xing, Yulong Hong, Tongtong Li, Geng Zong, Chong Yang, Dan Zhang, Zhangling Chen, Xin Jin   +10 more
wiley   +1 more source

TNF receptor–related factor 3 inactivation promotes the development of intrahepatic cholangiocarcinoma through NF‐κB‐inducing kinase–mediated hepatocyte transdifferentiation

Hepatology, EarlyView., 2022
Abstract Background and Aims Intrahepatic cholangiocarcinoma (ICC) is a deadly but poorly understood disease, and its treatment options are very limited. The aim of this study was to identify the molecular drivers of ICC and search for therapeutic targets.
Yuto Shiode, Takahiro Kodama, Satoshi Shigeno, Kazuhiro Murai, Satoshi Tanaka, Justin Y. Newberg, Jumpei Kondo, Shogo Kobayashi, Ryoko Yamada, Hayato Hikita, Ryotaro Sakamori, Hiroshi Suemizu, Tomohide Tatsumi, Hidetoshi Eguchi, Nancy A. Jenkins, Neal G. Copeland, Tetsuo Takehara   +16 more
wiley   +1 more source

Toll-like receptors in breast cancer immunity and immunotherapy

Frontiers in Immunology
Toll-like receptors (TLRs) are a key family of pattern recognition receptors (PRRs) in the innate immune system. The activation of TLRs will not only prevent pathogen infection but also respond to damage-induced danger signaling.
Joseph Zhou, Lin Zhang, Siyao Liu, David DeRubeis, Dekai Zhang   +4 more
doaj   +1 more source

The Inflammatory Role of Platelets via Their TLRs and Siglec Receptors

Frontiers in Immunology, 2015
Platelets are non-nucleated cells that play central roles in the processes of hemostasis, innate immunity, and inflammation; however, several reports show that these distinct functions are more closely linked than initially thought.
F. Cognasse, Kim Anh Nguyen, P. Damien, A. Mcnicol, B. Pozzetto, H. Hamzeh-Cognasse, O. Garraud   +6 more
semanticscholar   +1 more source

Bioengineered Exosome‐Loaded Immunomodulatory Bioadhesive Spray Reverses Liver Fibrosis and Metabolic Dysfunction That Triggers Beneficial Gut‐Liver Crosstalk in Chronic Fatty Liver Disease

Advanced Science, EarlyView.
Umbilical cord stem cell‐derived exosomes encapsulated in an immunomodulatory bioadhesive hydrogel spray enable localized therapy, sustained vesicle delivery, macrophage polarization, suppress systemic inflammation, and mitigate glucose and insulin homeostasis impairments in MAFLD.
Triya Saha, Ayushi Mairal, Shreya Mehrotra, Shiv K. Sarin, Ashok Kumar   +4 more
wiley   +1 more source

Enhanced mitochondrial activity reshapes a gut microbiota profile that delays NASH progression

Hepatology, EarlyView., 2022
Improved mitochondrial activity, due to the lack of methylation‐controlled J protein (MCJ), creates a specific microbiota signature that when transferred through cecal microbiota transplantation delays NASH progression by restoring the gut‐liver axis and enhancing hepatic fatty acid oxidation.
María Juárez‐Fernández, Naroa Goikoetxea‐Usandizaga, David Porras, María Victoria García‐Mediavilla, Miren Bravo, Marina Serrano‐Maciá, Jorge Simón, Teresa C. Delgado, Sofía Lachiondo‐Ortega, Susana Martínez‐Flórez, Óscar Lorenzo, Mercedes Rincón, Marta Varela‐Rey, Leticia Abecia, Héctor Rodríguez, Juan Anguita, Esther Nistal, María Luz Martínez‐Chantar, Sonia Sánchez‐Campos   +18 more
wiley   +1 more source

Genetic Variation in Toll-Like Receptors (TLRs) 2, 4, and 9 Influences HIV Disease Progression Toward Active TB and AIDS [PDF]

Gaurav Kaushik,1,2 Richa Vashishtha,2 Chaitenya Verma,3 Shipra Sharma,4 Vinay Kumar5 1School of Allied Health Sciences, Sharda University, Greater Noida, Uttar Pradesh, 201310, India; 2Department of Medicine, All India Institute of Medical Sciences, New ...
Verma C, Kaushik G, Vashishtha R, Kumar V, Sharma S   +4 more
core   +1 more source

Toll-Like Receptors, Their Ligands, and Atherosclerosis

The Scientific World Journal, 2011
Atherosclerosis is a disease characterized by inflammation in the arterial wall. Atherogenesis is dependent on the innate immune response involving activation of Toll-like receptors (TLRs) and the expression of inflammatory proteins.
Conrad P. Hodgkinson, Shu Ye
doaj   +1 more source