Results 111 to 120 of about 4,902 (167)

Intestinal epithelial ion channel TMEM16A deficiency impairs enteroendocrine cell differentiation and epithelial homeostasis and enhances anxiety-like behavior in mice

陆军军医大学学报
Objective Transmembrane member 16A (TMEM16A) is involved in intestinal epithelial ion transport and secretory homeostasis, but its effects on enteroendocrine cell (EEC) function and gut-brain axis-related behaviors remain unclear.
Wang Hao, Sun Meiyan
doaj   +1 more source

Compartmentalized crosstalk of CFTR and TMEM16A (ANO1) through EPAC1 and ADCY1

, 2018
Airway epithelial cells express both Ca2+activated TMEM16A/ANO1 and cAMP activated CFTR anion channels. Previous work suggested a significant crosstalk of intracellular Ca2+and cAMP signaling pathways, leading to activation of both chloride channels.
R. Benedetto, M. Aureli, K. Kunzelmann, J. Lérias, M. Amaral, M. Pinto, R. Schreiber   +6 more
core   +1 more source

Data_Sheet_1_Control of Ion Transport by Tmem16a Expressed in Murine Intestine.PDF

, 2019
Cl– secretion by the human and murine intestinal epithelium occurs through the cystic fibrosis transmembrane conductance regulator (cftr). However, the Ca2+ activated Cl– channel Tmem16a was shown to contribute to Cl– secretion, mainly, but not ...
Karl Kunzelmann (80303), Inês Cabrita (7461878), Podchanart Wanitchakool (5821628), Raquel Centeio (7461875), Rainer Schreiber (80302), Kazi Mirajul Hoque (822762), Roberta Benedetto (7461881), Tultul Saha (822761)   +7 more
core   +1 more source

GZMK⁺CD8⁺ T Cells Induce Acinar Cell Senescence and Salivary Secretion Impairment in Sjögren's Syndrome via Mitochondrial Dysfunction and TMEM16A Chloride Channel Disruption. [PDF]

Int J Biol Sci
Chai M, Xie Y, Cong X, Ding C, Wei P, Zhou P, Li B, Hua H.   +7 more
europepmc   +1 more source

Loss of Vascular TMEM16A Impairs Cerebral Autoregulation and Exacerbates Ischemia-reperfusion Injury. [PDF]

Transl Stroke Res
Andersen AC, Larsen ID, Melnikova EV, Gernemann M, Skryabin BV, Pedersen TM, Beck HC, Guldbrandsen HØ, Gutierrez E, Aalkjaer C, Postnov DD, Matchkov VV, Hansen LMB.   +12 more
europepmc   +1 more source

Epithelial Chloride and Bicarbonate Transport in Intestinal Barrier Failure: A Molecular Target-Validation Assessment of CFTR and SLC26A3/DRA in Inflammatory Bowel Disease. [PDF]

Int J Mol Sci
Seo Y.
europepmc   +1 more source

Extracellular zinc acts as a dynamic extracellular regulator of fertilization in Xenopus laevis†. [PDF]

Biol Reprod
Bainbridge RE, Komondor KM, Miller JM, Milnes BL, Brado OG, Harris KMT, Sau P, Barbara E, Khanzada S, Musuku R, Schack J, Carlson AE.   +11 more
europepmc   +1 more source

ANO1 (TMEM16A) Genetic Variants, Promoter Methylation, and Chloride Dysregulation in Pulmonary Hypertension. [PDF]

J Cardiovasc Dev Dis
Yaman İ, Korkmaz H, Akağaç AE, Kaymaz T, Önder R, Önalan EE.   +5 more
europepmc   +1 more source

TRPV4-driven ATP release activates CFTR through ADORA2B and P2RY2 receptors in the airway epithelium. [PDF]

iScience
Genovese M, De Santis M, Giordano A, Marotta P, Galietta LJV.   +4 more
europepmc   +1 more source

A pericyte chloride clamp mechanism governs capillary control of cerebral blood flow. [PDF]

Proc Natl Acad Sci U S A
Xiang L, Hariharan A, Isaacs D, Weir N, Longden TA.   +4 more
europepmc   +1 more source