Results 91 to 100 of about 3,924 (173)

Mechanism of persistent hyperalgesia in neuropathic pain caused by chronic constriction injury

Neural Regeneration Research, 2019
Transmembrane member 16A (TMEM16A) is involved in many physiological functions, such as epithelial secretion, sensory conduction, nociception, control of neuronal excitability, and regulation of smooth muscle contraction, and may be important in ...
Qin-Yi Chen, Chao-Yang Tan, Yang Wang, Ke-Tao Ma, Li Li, Jun-Qiang Si   +5 more
doaj   +1 more source

TMEM16A is associated with Voltage-gated Calcium Channels in mouse retina and its function is disrupted upon mutation of the auxiliary α2δ4 subunit.

Frontiers in Cellular Neuroscience, 2015
Photoreceptors rely upon highly specialized synapses to efficiently transmit signals to multiple postsynaptic targets. Calcium influx in the presynaptic terminal is mediated by voltage-gated calcium channels (VGCC).
Antonella eCaputo, Ilaria ePiano, Gian Carlo eDemontis, Niccolò eBacchi, Simona eCasarosa, Luca eDella Santina, Claudia eGargini   +6 more
doaj   +1 more source

Modulation of TMEM16A-Channel Activity as Ca2+ Activated Cl− Conductance via the Interaction With Actin Cytoskeleton in Murine Portal Vein

Journal of Pharmacological Sciences, 2014
.: TMEM16A is a major component of Ca2+-activated Cl− channel (CaCC) conductance in murine portal vein smooth muscle cells (mPVSMCs). Here, the regulation of CaCC activity by the actin cytoskeleton was examined in mPVSMCs.
Junya Ohshiro, Hisao Yamamura, Yoshiaki Suzuki, Yuji Imaizumi   +3 more
doaj   +1 more source

TMEM16A blocker as vasorelaxant

, 2013
Background and purposeT16A(inh) -A01 is a recently identified inhibitor of the calcium-activated chloride channel TMEM16A. The aim of this study was to test the efficacy of T16A(inh) -A01 for inhibition of calcium-activated chloride channels in vascular smooth muscle and consequent effects on vascular tone.Experimental approachSingle channel and whole ...
Davis, Alison J, Shi, Jian, Pritchard, Harry AT, Chadha, Preet S, Leblanc, Normand, Vasilikostas, Georgios, Yao, Zhen, Verkman, AS, Albert, Anthony P, Greenwood, Iain A   +9 more
openaire   +2 more sources

9‐phenanthrol inhibits TMEM16A channels

The FASEB Journal, 2013
Intravascular pressure stimulates several smooth muscle cell TRP channels, including TRPM4, leading to membrane depolarization and vasoconstriction (the myogenic response). Previous studies using 9‐phenanthrol (9‐phen), a TRPM4 channel inhibitor, suggest that TRPM4 is essential for pressure‐induced depolarization and constriction ...
Sarah Burris, Zachary P. Neeb, Jonathan Jaggar   +2 more
openaire   +1 more source

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Frontiers in Pharmacology, 2019
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Esther Trueblood, Esther Trueblood, Kelly Hensley, Kelly Hensley, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L. Born, Alison Budelsky, Mike Comeau, Dirk Smith, Jonathan Phillips, James A. Johnston, Joseph G. McGivern, Kerstin Weikl, David Powers, Karl Kunzelmann, Deanna Mohn, Andreas Hochheimer, John K. Sullivan   +36 more
doaj   +1 more source

TMEM16A Potentiation: Possible Drawbacks

American Journal of Respiratory and Critical Care Medicine, 2020
Andrea Olschewski, Chandran Nagaraj, Diana Zabini, Bence M. Nagy, Grazyna Kwapiszewska, Horst Olschewski   +5 more
openaire   +2 more sources

Pharmacological properties of native CaCCs and TMEM16A [PDF]

Channels, 2014
Kenton M, Sanders, Kate, O'Driscoll, Normand, Leblanc   +2 more
openaire   +2 more sources

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +1 more source

Intestinal epithelial ion channel TMEM16A deficiency impairs enteroendocrine cell differentiation and epithelial homeostasis and enhances anxiety-like behavior in mice

陆军军医大学学报
Objective Transmembrane member 16A (TMEM16A) is involved in intestinal epithelial ion transport and secretory homeostasis, but its effects on enteroendocrine cell (EEC) function and gut-brain axis-related behaviors remain unclear.
Wang Hao, Sun Meiyan
doaj   +1 more source