Results 81 to 90 of about 3,924 (173)

Pharmacological Modulation of Ion Channels for the Treatment of Cystic Fibrosis

Journal of Experimental Pharmacology, 2021
Madalena C Pinto,1,* Iris AL Silva,1,* Miriam F Figueira,2 Margarida D Amaral,1 Miquéias Lopes-Pacheco1,* 1Biosystems & Integrative Sciences Institute (BioISI), Faculty of Sciences, University of Lisboa, Lisboa, Portugal; 2Marsico Lung ...
Pinto MC, Silva IAL, Figueira MF, Amaral MD, Lopes-Pacheco M   +4 more
doaj  

Smooth muscle cell polycystin 1 (PKD1) is dispensable for physiological regulation of arterial contractility

The Journal of Physiology, Volume 604, Issue 15, Page 6348-6368, 1 August 2026.
Abstract figure legend Physiological functions of PKD1, a large transmembrane polycystin protein, are unclear. Previous results obtained using germline non‐specific knockout mice suggested that PKD1 regulates arterial smooth muscle cell contractility.
Angélica K. Bernardelli, Roberto B. Pontes, Alejandro Mata‐Daboin, Tessa A. C. Garrud, Ulrich C. Mbiakop, Marcos A. S. Leal, Dieniffer Peixoto‐Neves, Jonathan H. Jaggar   +7 more
wiley   +1 more source

Artificial Intelligence for Bone: Theory, Methods, and Applications

Advanced Intelligent Discovery, Volume 2, Issue 3, June 2026.
Advances in artificial intelligence (AI) offer the potential to improve bone research. The current review explores the contributions of AI to pathological study, biomarker discovery, drug design, and clinical diagnosis and prognosis of bone diseases. We envision that AI‐driven methodologies will enable identifying novel targets for drugs discovery. The
Dongfeng Yuan, Haicang Zhang, Liping Tong, Di Chen   +3 more
wiley   +1 more source

Calcium- and Voltage-Dependent Dual Gating ANO1 is an Intrinsic Determinant of Repolarization in Rod Bipolar Cells of the Mouse Retina

Cells, 2020
TMEM16A/anoctamin1 (ANO1), a calcium (Ca2+)-activated chloride (Cl−) channel, has many functions in various excitable cells and modulates excitability in both Ca2+- and voltage-gating modes.
Sun-Sook Paik, Yong Soo Park, In-Beom Kim   +2 more
doaj   +1 more source

Co-targeting TMEM16A with a novel monoclonal antibody and EGFR with Cetuximab inhibits the growth and metastasis of esophageal squamous cell carcinoma

Journal of Translational Medicine
The chloride channel transmembrane protein 16A (TMEM16A) possesses a calcium-activated property linked to tumor-promoting malignant phenotype and electrophysiological stability.
Yutian Zheng, Lin Meng, Like Qu, Chuanke Zhao, Lixin Wang, Jiayi Ma, Caiyun Liu, Chengchao Shou   +7 more
doaj   +1 more source

Bioengineered 3D hPSC‐Cholangiocyte Ducts With Physiological Signals for Biliary Disease Modeling

Advanced Healthcare Materials, Volume 15, Issue 20, 27 May 2026.
Tian and colleagues generated a bioengineered bile duct from human pluripotent stem cell (hPSC)‐derived intrahepatic cholangiocytes within a high‐throughput, 384‐well platform to systematically examine the influence of biliary physiological signals including fluid flow, stromal cells and bile acids, and models intrahepatic biliary disease progression ...
Britney Tian, Mina Ogawa, Manami Kondo, Gabrielle Langeveld, Ling Jun Huan, Feng Zhang, Andrew Hollinger, Sara Deir, Christine Bear, Boyang Zhang, Shinichiro Ogawa   +10 more
wiley   +1 more source

Upregulation of TMEM16A Protein in Bronchial Epithelial Cells by Bacterial Pyocyanin.

PLoS ONE, 2015
Induction of mucus hypersecretion in the airway epithelium by Th2 cytokines is associated with the expression of TMEM16A, a Ca2+-activated Cl- channel. We asked whether exposure of airway epithelial cells to bacterial components, a condition that mimics ...
Emanuela Caci, Paolo Scudieri, Emma Di Carlo, Patrizia Morelli, Silvia Bruno, Ida De Fino, Alessandra Bragonzi, Ambra Gianotti, Elvira Sondo, Loretta Ferrera, Alessandro Palleschi, Luigi Santambrogio, Roberto Ravazzolo, Luis J V Galietta   +13 more
doaj   +1 more source

Endothelial Dysfunction Following Enhanced TMEM16A Activity in Human Pulmonary Arteries

Cells, 2020
Endothelial dysfunction is one of the hallmarks of different vascular diseases, including pulmonary arterial hypertension (PAH). Ion channelome changes have long been connected to vascular remodeling in PAH, yet only recently has the focus shifted ...
Davor Skofic Maurer, Diana Zabini, Chandran Nagaraj, Neha Sharma, Miklós Lengyel, Bence M. Nagy, Saša Frank, Walter Klepetko, Elisabeth Gschwandtner, Péter Enyedi, Grazyna Kwapiszewska, Horst Olschewski, Andrea Olschewski   +12 more
doaj   +1 more source

Coumarins attenuate intestinal motility by inhibiting TMEM16A

Die Pharmazie
Transmembrane 16A (TMEM16A) is highly expressed in interstitial cells of Cajal (ICC) and participates in ICC-mediated rhythmic contractile activity of intestinal smooth muscle. TMEM16A is also expressed in epithelium of intestine with a minor contributor to transepithelial fluid secretion, while other unidentified Ca2+ -activated Cl – channels (unCaCCs)
Xiaojuan Zhu, Xiaojuan Zhu, Hao Wang, Hao Wang, Bo Yu, Bo Yu, Lingling Jin, Lingling Jin, Chao Qu, Chao Qu, Hongyan Li, Hongyan Li, Hong Yang, Hong Yang   +6 more
openaire   +2 more sources

Mechanisms underlying gastric antral slow waves – a human perspective

The Journal of Physiology, EarlyView.
Dirk F. van Helden
wiley   +1 more source