Results 101 to 110 of about 4,902 (167)

Drug Repurposing: The Anthelmintics Niclosamide and Nitazoxanide Are Potent TMEM16A Antagonists That Fully Bronchodilate Airways

Frontiers in Pharmacology, 2019
There is an unmet need in severe asthma where approximately 40% of patients exhibit poor β-agonist responsiveness, suffer daily symptoms and show frequent exacerbations.
Kent Miner, Katja Labitzke, Benxian Liu, Paul Wang, Kathryn Henckels, Kevin Gaida, Robin Elliott, Jian Jeffrey Chen, Longbin Liu, Anh Leith, Esther Trueblood, Esther Trueblood, Esther Trueblood, Kelly Hensley, Kelly Hensley, Kelly Hensley, Xing-Zhong Xia, Oliver Homann, Brian Bennett, Mike Fiorino, John Whoriskey, Gang Yu, Sabine Escobar, Min Wong, Teresa L. Born, Alison Budelsky, Mike Comeau, Dirk Smith, Jonathan Phillips, James A. Johnston, Joseph G. McGivern, Kerstin Weikl, David Powers, Karl Kunzelmann, Deanna Mohn, Andreas Hochheimer, John K. Sullivan   +36 more
doaj   +1 more source

TMEM16A-Mediated mucin secretion in IL-13-induced nasal epithelial cells from chronic rhinosinusitis patients [PDF]

, 2015
Purpose: Chronic rhinosinusitis with nasal polyps (CRSwNP), a mainly Th2 cytokine-mediated disease, often involves mucus secretion. Recent evidence suggests that transmembrane protein 16A (TMEM16A), a calcium-activated or channel (CaCC), can regulate ...
Jiao, Jian, Wang, X, Fan, E, Bachert, Claus, Zhang, Yu, Zhang, Y, Jiao, J, Wang, H, Bachert, C,, Li, Ying, Wang, Hong, Fan, Erzhong, Li, Y, Zhang, L, Zhang, Luo, Wang, Xiangdong   +15 more
core   +1 more source

Expression of TMEM16A and SLC4A4 in human pancreatic islets.

, 2011
Stimulation of insulin release by D-glucose is accompanied by Cl(-) and HCO(3)(-) efflux from pancreatic islet cells. The efflux of these anions may involve volume-regulated anion channels, including possibly TMEM16A, and the Na(+)-HCO(3 ...
Gomis, Ramon, Lybaert, Pascale, Sener, Abdullah, Gasa, Rosa, Bulur, Nurdan, Malaisse, Willy, Beauwens, Renaud, Hanzu, Felicia A   +7 more
core   +1 more source

Increased complexity of Tmem16a/Anoctamin 1 transcript alternative splicing [PDF]

, 2011
Background TMEM16A (Anoctamin 1; ANO1) is an eight transmembrane protein that functions as a calcium-activated chloride channel. TMEM16A in human exhibits alternatively spliced exons (6b, 13 and 15), which confer important roles in the ...
Fiona C Britton, Rachel A Pipe, Kate E O'Driscoll   +2 more
core   +1 more source

TGF-beta effects on TMEM16A and CFTR protein levels in T84 cells and HAECs.

, 2014
Lysates of T84 cells (A and B) or HAECs (C and D) were prepared and subjected to PAGE and immunoblot with either anti-TMEM16A or anti-CFTR antibody. For each cell type, the upper gel panel shows TMEM16A (A and C) or CFTR (B andD) detection from three ...
Yan Sanders (636855), Anusha Sridharan (634793), Alicia J. Ostmann (456924), Amir Rezayat (456925), Stephanie Kortyka (636853), William T. Harris (444214), Hongtao Sun (456928), Anjaparavanda P. Naren (583409), John P. Clancy (438294), Kavitha Kotha (636854)   +9 more
core   +1 more source

Immunofluorescence labeling of TMEM16A in CRC cell lines.

, 2014
Cells were grown on coverslips and stained with anti-TMEM16A antibodies. Left column, anti-TMEM16A immunofluorescence (Cy3, red). Middle column, DAPI staining to visualize nuclei.
Xuedong Fang (227155), Lili Zhong (679551), Meiyan Sun (679548), Tonghui Ma (549091), Guizhen Zhang (679550), Jinhao Zheng (679553), Yujie Sui (549090), Zhiming Ma (679552), Fei Wu (117860), Weihua Di (679549), Longfei Yang (435484)   +10 more
core   +1 more source

CFTR and TMEM16A are Separate but Functionally Related Cl^- Channels

, 2011
Previous reports point out to a functional relationship of the cystic fibrosis transmembrane conductance regulator (CFTR) and Ca2+ activated Cl- channels (CaCC).
Kongsuphol, Patthara, Ousingsawat, Jiraporn, Kunzelmann, Karl, Schreiber, Rainer   +3 more
core   +1 more source

The Tmem16a chloride channel is required for mucin maturation after secretion from goblet-like cells in the Xenopus tropicalis tadpole skin

Scientific Reports
The TMEM16A chloride channel is proposed as a therapeutic target in cystic fibrosis, where activation of this ion channel might restore airway surface hydration and mitigate respiratory symptoms.
Eamon Dubaissi, Emma N. Hilton, Sarah Lilley, Richard Collins, Charlotte Holt, Peter March, Henry Danahay, Martin Gosling, Richard K Grencis, Ian S Roberts, David J Thornton   +10 more
doaj   +1 more source

Intermolecular interactions in the TMEM16A dimer controlling channel activity

, 2016
TMEM16A and TMEM16B are plasma membrane proteins with Ca2+-dependent Cl- channel function. By replacing the carboxy-terminus of TMEM16A with the equivalent region of TMEM16B, we obtained channels with potentiation of channel activity.
Gianotti A., Moran O., Scudieri, Paolo, Gianotti, Ambra, Moran, Oscar, Musante, Ilaria, Galietta, Luis J. V., Scudieri P., Musante I., Galietta L. J. V.   +9 more
core   +1 more source

Loss of TMEM16A Causes a Defect in Epithelial Ca2+-dependent Chloride Transport

, 2009
Molecular identification of the Ca2+-dependent chloride channel TMEM16A (ANO1) provided a fundamental step in understanding Ca2+-dependent Cl- secretion in epithelia.
Martins, Joana R., Harfe, Brian D., Ousingsawat, Jiraporn, Kunzelmann, Karl, Schreiber, Rainer, Rock, Jason R.   +5 more
core   +1 more source