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Erythroid differentiation in mouse erythroleukemia cells depends on Tmod3‐mediated regulation of actin filament assembly into the erythroblast membrane skeleton

FASEB Journal, 2022
Abstract Erythroid differentiation (ED) is a complex cellular process entailing morphologically distinct maturation stages of erythroblasts during terminal differentiation. Studies of actin filament (F‐actin) assembly and organization during terminal ED have revealed essential roles for the F‐actin pointed‐end ...
Velia Fowler, Arit Ghosh, Richard West +2 more
exaly +3 more sources

TMOD3 accelerated resistance to immunotherapy in KRAS-mutated pancreatic cancer through promoting autophagy-dependent degradation of ASCL4

Drug Resistance Updates
The high prevalence of KRAS mutations in pancreatic cancer (PC) is widely acknowledged and results in the resistance of targeted ferroptosis therapy and immunotherapy. Herein, via a CRISPR/Cas9 library screen, the effects of ferroptosis agonists were increased in KRAS-mutant PC cells upon knockout of tropomodulin 3 (TMOD3), while these effects were not
Zhirui Zeng
exaly +3 more sources

Tropomyosin-binding properties modulate competition between tropomodulin isoforms

Archives of Biochemistry and Biophysics, 2016
The formation and fine-tuning of cytoskeleton in cells are governed by proteins that influence actin filament dynamics. Tropomodulin (Tmod) regulates the length of actin filaments by capping the pointed ends in a tropomyosin (TM)-dependent manner. Tmod1,
Natalia Moroz, Alla Kostyukova, Mert Çolpan +2 more
exaly +2 more sources

TMOD3 May Promote Pancreatic Cancer Progression Validated by Bioinformatics Analysis and Tissue Microarrays